Home Ingredients Slimaluma® (Caralluma fimbriata for Appetite)
Weight Management

Slimaluma® (Caralluma fimbriata for Appetite)

Caralluma fimbriata
Evidence Level
Moderate
2 Clinical Trials
5 Documented Benefits
3/5 Evidence Score

Slimaluma® is a standardized caralluma fimbriata extract developed by Saanroo (formerly Gencor Pacific) — derived from a succulent traditionally used as appetite suppressant by tribal hunters in India. Distinguished by FDA letter of no objection for meal replacement products, US patent protection, multiple RCTs showing waist circumference reduction. Used for weight management, particularly appetite control.

Studied Dose 500-1,000 mg/day; clinical trials use 500 mg/day or 1 g/day
Active Compound Pregnane glycosides, megastigmane glycosides (proprietary standardized fraction)

Benefits

Waist Circumference Reduction

Multiple RCTs show Slimaluma significantly reduces waist circumference vs placebo. Kuriyan 2007 (n=50, 60 days) and subsequent studies. Visceral fat reduction beyond just weight loss.

Supported by Trial 1

Appetite Suppression

Traditional use by tribal hunters in India for hunger suppression during long hunting periods. Modern clinical evidence supports appetite control mechanism.

Supported by Trial 1

Body Composition Improvements

Reductions in body fat mass, body weight, BMI in clinical trials. Effects modest but consistent.

Supported by Trial 1

FDA Letter of No Objection

FDA issued letter of no objection for Slimaluma use in meal replacement products — regulatory acknowledgment of safety.

Supported by Trial 2

Comprehensive Safety Assessment

Multiple safety studies including comprehensive toxicology assessments published. Safety profile well-characterized.

Supported by Trial 2

Mechanism of action

1

Hypothalamic Appetite Center Modulation

Theoretical mechanism: pregnane glycosides modulate hypothalamic appetite control centers.

2

Reduced Food Intake / Caloric Deficit

Appetite suppression leads to reduced caloric intake — foundation for weight management effects.

3

Citrate Lyase Inhibition

Some research suggests inhibition of citrate lyase — enzyme involved in fatty acid synthesis.

4

Standardized Pregnane Glycoside Profile

Saanroo standardization ensures consistent active compound delivery.

Clinical trials

1
Slimaluma for Weight Management

Clinical trial of Slimaluma (1 g/day) vs placebo in 50 overweight Indian adults for 60 days.

50 overweight adults.

Significant reduction in waist circumference and waist:hip ratio vs placebo. Modest body weight effects.

2
Slimaluma Safety Assessment

Comprehensive toxicology studies of Slimaluma for regulatory submissions.

Animal toxicology and human safety.

Well-tolerated at supplemental doses; no significant adverse effects in long-term safety studies.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress (initial).
Constipation possible.
Allergic reactions rare.

Important Drug interactions

Diabetes medications — modest hypoglycemic effects from reduced food intake.
Antihypertensives — modest BP effects from weight loss.
Pregnancy/lactation — limited safety data; avoid supplementation.
Children — not appropriate for pediatric weight management without medical supervision.

More Weight Management Ingredients

Weight Management
Capsaicin / Capsicum Extract (Cayenne Pepper)
Capsicum extract (cayenne pepper, red chili pepper) and its primary bioactive capsaicin ar…
Weight Management
Glucomannan (Konjac Root Fiber)
Glucomannan is a water-soluble dietary fiber derived from the root of the konjac plant (Am…
Weight Management
Supresa® (Saffron Extract for Appetite & Crave Control — PLT Health)
Supresa® is PLT Health Solutions' patented saffron (Crocus sativus L.) stigma extract — cl…
Weight Management
Erythritol
Erythritol is a 4-carbon sugar alcohol (polyol) — about 60-70% as sweet as sucrose with es…

Frequently asked questions about Slimaluma® (Caralluma fimbriata for Appetite)

What is Slimaluma?

Slimaluma® is a standardized caralluma fimbriata extract developed by Saanroo (formerly Gencor Pacific) — derived from a succulent traditionally used as appetite suppressant by tribal hunters in India.

What is Slimaluma used for?

Slimaluma is researched primarily for Weight Management. Multiple RCTs show Slimaluma significantly reduces waist circumference vs placebo. Kuriyan 2007 (n=50, 60 days) and subsequent studies. Visceral fat reduction beyond just weight loss.

What is the recommended dosage of Slimaluma?

The clinically studied dose is 500-1,000 mg/day; clinical trials use 500 mg/day or 1 g/day Always follow the product label and check with a healthcare provider for personal advice.

Is Slimaluma safe, and does it have side effects?

For most healthy adults, Slimaluma is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild GI distress (initial). It may also interact with some medications. Slimaluma is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Slimaluma interact with any medications?

Possible interactions include: Diabetes medications — modest hypoglycemic effects from reduced food intake. Antihypertensives — modest BP effects from weight loss. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Slimaluma?

NutraSmarts rates the evidence for Slimaluma as Moderate (3 out of 5). It is backed by 2 clinical trials and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Rao A, Briskey D, Dos Reis C, et al. The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults. Sci Rep. 2021;11(1):6791..PubMedUsed to support: Randomized trial of Caralluma fimbriata extract (Slimaluma) on appetite control and body composition.