SelectSIEVE® Olive (Olive Polyphenols — Roelmi HPC)

Olea europaea
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

SelectSIEVE® Olive is a standardized olive (Olea europaea) polyphenol extract from Roelmi HPC. Its oleuropein and hydroxytyrosol contribute antioxidant activity; the human evidence for olive polyphenols is strongest for protecting blood lipids from oxidation, and no trial of SelectSIEVE Olive itself has been published.

Studied Dose Commonly 250 to 1000 mg of olive extract per day.
Active Compound Olive (Olea europaea) polyphenols, oleuropein and hydroxytyrosol.

Benefits

Cardiovascular support

In a controlled trial a related olive leaf extract did not significantly change blood pressure or blood lipids. The clearest human evidence for olive polyphenols is that olive oil polyphenols raise HDL cholesterol and lower oxidized LDL. No trial of SelectSIEVE Olive itself has been published.

Antioxidant defense

Hydroxytyrosol and oleuropein are powerful antioxidants that protect cells and LDL cholesterol from oxidation.

Blood sugar and lipids: no measured benefit

In the cited human trial olive polyphenols did not significantly change blood sugar, insulin or blood lipids. Any metabolic benefit is unproven.

Mechanism of action

1

Olive polyphenol action

Oleuropein and hydroxytyrosol support nitric-oxide-mediated blood-vessel relaxation and antioxidant defense.

2

Anti-inflammatory action

Olive polyphenols calm oxidative and inflammatory stress in blood vessels and tissues.

Clinical trials

1
Olive Leaf Extract, Cardiovascular Markers (null RCT, different product)
PubMed

Randomized, double-blind, placebo-controlled trial of a different branded olive LEAF extract (500 mg/day for 8 weeks) in 77 overweight adults with mildly elevated cholesterol. It found no significant effect on any cardiovascular marker. This is not a trial of SelectSIEVE Olive. (Stevens et al. 2021, European Journal of Nutrition)

Adults.

In this trial the olive leaf extract did not significantly change blood lipids, oxidized LDL, blood pressure, glucose, insulin or liver markers compared with placebo over 8 weeks.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Blood pressure medication — olive polyphenols may have an additive effect; monitor.
Diabetes medication — may modestly lower blood sugar; monitor.
Tell your doctor if you take cardiovascular medication.

Frequently asked questions about SelectSIEVE® Olive (Olive Polyphenols — Roelmi HPC)

What is SelectSIEVE Olive?

SelectSIEVE® Olive is a standardized olive (Olea europaea) polyphenol extract from Roelmi HPC. Its oleuropein and hydroxytyrosol contribute antioxidant activity; the human evidence for olive polyphenols is strongest for protecting blood lipids from oxidation, and no trial of SelectSIEVE Olive itself has been published.

What is SelectSIEVE Olive used for?

SelectSIEVE Olive is researched primarily for Cardiovascular and Antioxidant. In a controlled trial a related olive leaf extract did not significantly change blood pressure or blood lipids. The clearest human evidence for olive polyphenols is that olive oil polyphenols raise HDL cholesterol and lower oxidized LDL.

What is the recommended dosage of SelectSIEVE Olive?

The clinically studied dose is Commonly 250 to 1000 mg of olive extract per day. Always follow the product label and check with a healthcare provider for personal advice.

Is SelectSIEVE Olive safe, and does it have side effects?

For most healthy adults, SelectSIEVE Olive is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild digestive upset is occasionally reported. It may also interact with some medications. SelectSIEVE Olive is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does SelectSIEVE Olive interact with any medications?

Possible interactions include: Blood pressure medication — olive polyphenols may have an additive effect; monitor. Diabetes medication — may modestly lower blood sugar; monitor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for SelectSIEVE Olive?

NutraSmarts rates the evidence for SelectSIEVE Olive as Limited (2 out of 5). It is backed by 1 clinical trial and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Stevens Y, Winkens B, Jonkers D, et al. The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial. Eur J Nutr. 2021;60(4):2111-2120..PubMedUsed to support: An 8-week randomized, placebo-controlled trial of a different branded olive LEAF extract (500 mg/day) in 77 overweight adults with mildly raised cholesterol. It found no significant effect on blood lipids, oxidized LDL, blood pressure, glucose or insulin. It does not test SelectSIEVE Olive.
  2. Covas MI, Nyyssonen K, Poulsen HE, et al.; EUROLIVE Study Group. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006;145(5):333-341. doi: 10.7326/0003-4819-145-5-200609050-00006.PubMedUsed to support: EUROLIVE, a randomized crossover trial in 200 healthy men, found that higher-polyphenol olive oil raised HDL cholesterol and lowered oxidized LDL in a dose-dependent way. This is the basis of the EFSA-authorized claim that olive polyphenols help protect blood lipids from oxidative damage. It tested olive oil, not this branded extract.