Passion Fruit (Passiflora edulis)

Passiflora edulis
Evidence Level
Limited
8 Clinical Trials
6 Documented Benefits
2/5 Evidence Score

Passion fruit is the fruit of the vine Passiflora edulis, grown in purple and yellow forms. The pulp with its seeds is eaten fresh or pressed for juice, while the peel and seeds are dried into flours and extracts. It is a different plant and plant part from passionflower (Passiflora incarnata leaf and flower), a calming herb. By USDA figures, 100 g of raw purple pulp with seeds supplies about 10 g of fiber and 30 mg of vitamin C. Human trials test three materials, each in small groups: seed-derived piceatannol (from its maker, Morinaga) for skin hydration and insulin markers, a purple peel extract, tested by its patent holders, in adults with knee or breathing complaints, and yellow peel flour for blood sugar, where one trial found lower fasting glucose than placebo and another found no change. The peel contains cyanide-forming compounds, and people with latex allergy can react to the fruit.

Studied Dose Seed extract: 5 to 20 mg/day of piceatannol for 8 weeks. Purple peel extract: 150 mg/day for 4 to 8 weeks. Yellow peel (albedo) flour: 1.5 g/day in capsules for 120 days, or rind flour 12 g three times daily for 8 weeks.
Active Compound Pulp with seeds: dietary fiber, vitamin C, provitamin A carotenoids and potassium. Seeds: the stilbene piceatannol, a resveratrol relative. Peel: mostly insoluble fiber, plus anthocyanins and other plant compounds. The fruit also contains the cyanogenic glycosides prunasin and sambunigrin.

Benefits

A food source of fiber, vitamin C and vitamin A

Per 100 g, raw purple passion fruit (pulp with seeds) provides about 10.4 g of total fiber, 30 mg of vitamin C, 64 mcg RAE of vitamin A and 348 mg of potassium for 97 kcal, according to USDA data. One fruit without refuse weighs about 18 g, so a single fruit adds roughly 2 g of fiber and 5 mg of vitamin C.

Skin hydration and wrinkle grades with seed-derived piceatannol

In an 8-week placebo-controlled trial in 82 Japanese women, enrolled partly for drier skin, a daily drink with 10 mg of piceatannol from passion fruit seeds raised facial skin hydration and improved wrinkle grades more than placebo. An earlier 32-woman trial of seed extract (5 mg piceatannol) beat placebo on moisture only in the driest-skin subgroup. The maker, Morinaga, funded or ran both. These test a seed concentrate, not the fruit.

Fasting blood sugar with yellow passion fruit peel flour

In a 120-day placebo-controlled trial in 89 adults with type 2 diabetes, 1.5 g a day of yellow passion fruit albedo (inner peel) flour in capsules lowered fasting glucose and HbA1c more than placebo. In a separate 8-week open trial in 54 adults with type 2 diabetes, 36 g a day of rind flour did not change fasting glucose or HbA1c compared with usual care.

Insulin markers with seed piceatannol in overweight men

In an 8-week placebo-controlled trial of 39 adults, 20 mg a day of piceatannol purified from passion fruit seed extract lowered insulin and HOMA-IR versus placebo only in overweight men (5 per group); the other subgroups showed no change. Morinaga funded the trial, supplied the capsules and employed two authors. A 7-day trial in 8 active men found no change in fat burning.

Knee pain, stiffness and function scores with a purple peel extract

In a 2-month placebo-controlled trial in 33 adults with knee osteoarthritis, 150 mg a day of purple passion fruit peel extract lowered self-rated WOMAC pain, stiffness and function scores by about 18 to 20%, while scores rose on placebo. A 2018 meta-analysis found a large pain effect versus placebo but noted it rested on this single trial. Three authors held a US patent on the extract.

Wheeze, cough and breathlessness reports with a purple peel extract

In a 4-week placebo-controlled trial in adults with asthma, 150 mg a day of purple passion fruit peel extract reduced reported wheeze, cough and shortness of breath and raised forced vital capacity, while placebo did not. FEV1, a key lung function measure, did not improve. Results are within-group, two authors held a US patent on the extract, and it is not a substitute for asthma care.

Mechanism of action

1

Piceatannol, a resveratrol relative concentrated in the seeds

Passion fruit seeds contain large amounts of piceatannol, a stilbene closely related to resveratrol. In muscle cells it raised SIRT1, an enzyme tied to energy and fat handling, and in a 2-week trial by its maker, 100 mg a day raised SIRT1 gene activity in blood more than placebo. That is a laboratory marker, not a health outcome; see the piceatannol page for more.

2

Peel fiber that binds water

In laboratory analysis of yellow passion fruit rind, total dietary fiber made up more than 73% of the alcohol-insoluble material, most of it insoluble, and the fiber held more than 3 g of water per gram. This bulk fiber is the main reason peel flours are studied with meals; it is a composition finding, not a human outcome.

3

Peel extract compounds and blood pressure in rats

In spontaneously hypertensive rats, a single oral dose of passion fruit peel extract at 50 mg/kg or more lowered blood pressure versus control, and its edulilic acid and anthocyanin fractions did the same while its GABA did not. The first author worked for Kemin, an ingredient company. This is animal work; effects in people are not established.

Clinical trials

1
Piceatannol Drink from Passion Fruit Seeds and Skin Hydration: 82-Woman RCT (maker-run)
PubMed

Randomized, double-blind, placebo-controlled trial of a daily drink with 10 mg of piceatannol derived from passion fruit seeds for 8 weeks, registered UMIN000056580; Morinaga funded it and employed 9 of 11 authors. (Seto et al. 2026, Front Nutr)

Healthy Japanese women aged 30 to 59; 86 enrolled and 82 analyzed (41 per group).

Facial stratum corneum hydration rose significantly more than with placebo, and wrinkle grades improved significantly versus placebo. Women with relatively lower baseline hydration were prioritized for enrollment, and one mild adverse event (transient hives, judged unrelated) occurred on piceatannol.

2
Passion Fruit Seed Extract and Dry Skin: 32-Woman RCT (maker-run)
PubMed

Randomized, placebo-controlled, double-blind trial of passion fruit seed extract supplying 5 mg of piceatannol a day, versus dextrin placebo, for 8 weeks; three of four authors were from Morinaga. (Maruki-Uchida et al. 2018, J Nutr Sci Vitaminol)

32 healthy Japanese women aged 35 to 54 with dry skin.

Skin moisture rose within the extract group at 4 and 8 weeks; a between-group gain over placebo was seen only in a subgroup with the driest skin. Transepidermal water loss fell but not significantly. Questionnaire ratings of perspiration and fatigue were lower than with placebo.

3
Piceatannol from Passion Fruit Seeds and Metabolic Markers: 39-Adult RCT
PubMed

Investigator-initiated, randomized (1:1), double-blind, placebo-controlled parallel trial of 20 mg/day piceatannol purified from passion fruit seed extract (81.4% purity) for 8 weeks, analyzed within four sex and weight groups; funded by Morinaga, which also supplied the capsules and paid the salaries of two authors. (Kitada et al. 2017, Nutrients)

39 adults in Japan: 10 overweight men, 9 overweight women, 10 non-overweight men and 10 non-overweight women.

In overweight men (5 per group), the change in fasting insulin (minus 18.8% vs plus 23.7%) and HOMA-IR differed from placebo, though their baseline insulin was higher than in the placebo group; blood pressure and heart rate fell within the piceatannol group. Non-overweight men and both groups of women showed no benefit on these measures. Body weight, lipids, inflammation, oxidative stress, endothelial function and mood did not change.

4
Seven Days of Piceatannol and Fat Burning During Exercise: 8-Man Crossover (null)
PubMed

Randomized, double-blind, placebo-controlled crossover of piceatannol tablets (Passienol, Morinaga) at 10 mg/day for 7 days, funded by university grants. (Kasai et al. 2025, J Clin Biochem Nutr)

8 physically active young men, tested at rest, during 60 minutes of low-intensity cycling and after.

Oxygen uptake, respiratory exchange ratio and blood fat-burning markers (free fatty acids, glycerol, ketones) did not differ from placebo at any point. Growth hormone, cortisol and insulin responses also did not differ.

5
Yellow Passion Fruit Albedo Flour vs Turmeric vs Placebo for 120 Days: 89-Adult RCT
PubMed

Randomized, placebo-controlled trial with three arms: yellow passion fruit albedo flour capsules (500 mg three times daily), turmeric with piperine, or carboxymethyl cellulose placebo alongside standard dietary advice. (Sousa et al. 2021, J Am Coll Nutr)

89 adults with type 2 diabetes.

Fasting glucose fell 5.9% with albedo flour versus a 9% rise on placebo (p < 0.05), and HbA1c fell 0.8% in both active arms versus placebo. Albedo flour did not lower triglycerides (plus 1.8%) or HOMA-IR more than placebo; turmeric did. The authors judged turmeric more cost-effective.

6
Yellow Passion Fruit Rind Flour and Glycemic Control: 54-Adult Open RCT (null)
PubMed

Open, prospective, randomized trial in matched pairs: 12 g of rind flour before each of three meals (36 g/day) for 8 weeks versus usual health service care; funded by Brazil's national research council (CNPq) and registered retrospectively. (de Araújo et al. 2017, J Diabetes Metab Disord)

54 adults with type 2 diabetes in Brazil.

Capillary glucose (p = 0.562), fasting glucose (p = 0.268) and HbA1c (p = 0.229) did not differ between groups after 8 weeks. The authors concluded the flour did not improve glycemic control in this sample.

7
Purple Passion Fruit Peel Extract and Knee Symptom Scores: 33-Adult RCT
PubMed

Randomized, double-blind, placebo-controlled, parallel-group trial of purple passion fruit peel extract pills (150 mg/day) for 2 months; three authors (Watson, Foo and Lu) were inventors on a US patent for this extract, assigned to Watson's consulting firm and New Zealand's Industrial Research Ltd; the abstract names no funder. (Farid et al. 2010, Nutr Res)

33 adults with knee osteoarthritis in Iran.

WOMAC total and function scores improved within the extract group by 30 days and pain by 60 days, with reductions of 18.6% (pain), 18% (stiffness), 19.6% (function) and 19.2% (total) at 60 days; scores rose in every category on placebo. The abstract does not report a between-group test; a 2018 meta-analysis that included only this trial computed a large pain effect versus placebo (effect size 1.65) and warned that a single-trial estimate is likely to change.

8
Purple Passion Fruit Peel Extract and Breathing Symptoms: 4-Week RCT
PubMed

Randomized, double-blind, placebo-controlled trial of purple passion fruit peel extract (150 mg/day), described as a mixture of bioflavonoids, for 4 weeks; the first author listed his private consulting firm in Arizona, and he and Foo LY were inventors on a US patent for this extract assigned to that firm and Industrial Research Ltd; the abstract names no funder. (Watson et al. 2008, Nutr Res)

Adults with asthma; the abstract gives no number; the related patent reports 44 enrolled and 42 completing.

Reported wheeze, cough and shortness of breath fell significantly within the extract group but not the placebo group, and forced vital capacity rose with the extract. FEV1 did not improve. No adverse effects were reported. Results are framed as changes within each group.

Side effects and drug interactions

Common Potential side effects

Latex-fruit cross-reactions: in 136 people with latex allergy, IgE antibodies that cross-reacted between latex and several fruits, passion fruit among them, were found, and 42.5% reported symptoms after eating such fruits. People allergic to latex should take care with passion fruit.
Cyanide-forming compounds: the fruit contains the cyanogenic glycosides prunasin and sambunigrin, and the white inner peel (mesocarp) releases hydrogen cyanide when its tissue is damaged. Peel flours and peel extracts are therefore a different matter from eating the ripe pulp; follow product directions and do not eat large amounts of raw peel.
Raw pulp with seeds is high in fiber (about 10.4 g per 100 g, USDA), so large servings or peel flours add a lot of fiber at once; increase intake gradually.
In the extract and seed trials cited here, no adverse effects were reported for peel extract over 4 weeks, and adverse events did not differ from placebo over 8 weeks of seed piceatannol, but the trials were small and short.
Passionflower (Passiflora incarnata) carries its own cautions, such as drowsiness; those findings come from a different plant and do not transfer to passion fruit.

Important Drug interactions

Diabetes medicines: yellow passion fruit albedo flour lowered fasting glucose versus placebo in a 120-day trial in adults with type 2 diabetes. If you take glucose-lowering medicines and add peel flour, check your readings and tell your doctor.
Blood pressure medicines: blood pressure and heart rate fell within the piceatannol group of overweight men in one small trial (no difference from placebo was reported), and peel extract lowered blood pressure in rats; watch for added effects if you take these medicines.
No formal drug interaction studies of passion fruit pulp, peel flour or seed extract were found; eating the fruit as food is not known to interact with medicines.

Frequently asked questions about Passion Fruit (Passiflora edulis)

Is passion fruit the same as passionflower?

No. Passion fruit comes from Passiflora edulis and is eaten as food, while passionflower supplements use the leaves and flowers of Passiflora incarnata, a different species studied as a calming herb. The sleep and calm trials on the passionflower page used P. incarnata preparations, not passion fruit pulp, juice, peel or seed.

Does passion fruit juice help with sleep or calm?

That has not been shown. A PubMed search in October 2026 found no placebo-controlled trial of passion fruit juice or pulp that measured sleep or anxiety. Claims that borrow from passionflower research mix up two different plants.

How much fiber and vitamin C is in a passion fruit?

USDA data list about 10.4 g of fiber and 30 mg of vitamin C per 100 g of raw purple passion fruit pulp with seeds. One fruit without refuse weighs about 18 g, so each fruit adds roughly 2 g of fiber and 5 mg of vitamin C, and a cup (236 g) about 25 g of fiber.

What is passion fruit peel flour, and is it safe to eat?

It is the dried, ground peel, often the white inner layer (albedo) of yellow passion fruit, used mainly as a fiber source. Trials gave 1.5 to 36 g a day. The peel contains cyanogenic glycosides that release hydrogen cyanide when the tissue is damaged, so use processed products as directed rather than eating large amounts of raw peel.

Who should be careful with passion fruit?

People allergic to latex, since passion fruit is among the fruits whose allergens cross-react with latex. People on glucose-lowering or blood pressure medicines who take peel flour or seed extracts should tell their doctor, because small trials found lower fasting glucose or insulin than placebo, or a within-group fall in blood pressure.

What is Passion Fruit?

Passion fruit is the fruit of the vine Passiflora edulis, grown in purple and yellow forms. The pulp with its seeds is eaten fresh or pressed for juice, while the peel and seeds are dried into flours and extracts.

What is Passion Fruit used for?

Passion Fruit is researched primarily for Metabolic Health and Joint Health. Per 100 g, raw purple passion fruit (pulp with seeds) provides about 10.4 g of total fiber, 30 mg of vitamin C, 64 mcg RAE of vitamin A and 348 mg of potassium for 97 kcal, according to USDA data.

What is the recommended dosage of Passion Fruit?

The clinically studied dose is Seed extract: 5 to 20 mg/day of piceatannol for 8 weeks. Purple peel extract: 150 mg/day for 4 to 8 weeks. Yellow peel (albedo) flour: 1.5 g/day in capsules for 120 days, or rind flour 12 g three times daily for 8 weeks. Always follow the product label and check with a healthcare provider for personal advice.

Is Passion Fruit safe, and does it have side effects?

Side effects and cautions reported for Passion Fruit include: Latex-fruit cross-reactions: in 136 people with latex allergy, IgE antibodies that cross-reacted between latex and several fruits, passion fruit among them, were found, and 42.5% reported symptoms after eating such fruits. It may also interact with some medications. Passion Fruit is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Passion Fruit interact with any medications?

Possible interactions include: Diabetes medicines: yellow passion fruit albedo flour lowered fasting glucose versus placebo in a 120-day trial in adults with type 2 diabetes. If you take glucose-lowering medicines and add peel flour, check your readings and tell your doctor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Passion Fruit?

NutraSmarts rates the evidence for Passion Fruit as Limited (2 out of 5). It is backed by 8 study summaries and 17 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(17 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central: Passion-fruit, (granadilla), purple, raw (SR Legacy, FDC ID 169108). USDA FoodData Central. 2019;SR Legacy food 169108; accessed October 2026..SourceUsed to support: Not PubMed-indexed. Nutrient values per 100 g of raw purple passion fruit (Passiflora edulis f. edulis): 97 kcal, 23.4 g carbohydrate, 10.4 g total dietary fiber, 30.0 mg vitamin C, 64 mcg RAE vitamin A, 743 mcg beta-carotene, 348 mg potassium. One fruit without refuse is listed as 18 g and one cup as 236 g.
  2. Seto Y, Tsukiashi M, Yamaguchi T, Kawakami S, Maruki-Uchida H, Nishimura E, Mori S, Ito M, Jin K, Maeda K, Iemoto N. Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial. Front Nutr. 2026;13:1765478. doi: 10.3389/fnut.2026.1765478.PubMedUsed to support: Randomized, double-blind, placebo-controlled trial in healthy Japanese women aged 30 to 59 (86 enrolled, 82 analyzed): a drink with 10 mg/day of piceatannol from passion fruit seeds for 8 weeks raised facial stratum corneum hydration and improved wrinkle grades significantly versus placebo. Nine of eleven authors were employees of the maker Morinaga, which funded the study.
  3. Maruki-Uchida H, Morita M, Yonei Y, Sai M. Effect of Passion Fruit Seed Extract Rich in Piceatannol on the Skin of Women: A Randomized, Placebo-Controlled, Double-Blind Trial. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):75-80. doi: 10.3177/jnsv.64.75.PubMedUsed to support: Randomized, double-blind trial in 32 Japanese women aged 35 to 54 with dry skin: passion fruit seed extract (5 mg piceatannol) or dextrin placebo for 8 weeks. Moisture rose within the extract group; versus placebo it was higher only in a subgroup with moisture values of 200 microsiemens or less. Transepidermal water loss fell non-significantly; perspiration and fatigue ratings fell versus placebo. Three authors were from Morinaga, one from Doshisha University.
  4. Kitada M, Ogura Y, Maruki-Uchida H, Sai M, Suzuki T, Kanasaki K, Hara Y, Seto H, Kuroshima Y, Monno I, Koya D. The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans. Nutrients. 2017;9(10):1142. doi: 10.3390/nu9101142.PubMedUsed to support: Investigator-initiated, randomized (1:1), placebo-controlled trial in 39 adults: 20 mg/day piceatannol purified from passion fruit seed extract for 8 weeks. In overweight men the change in serum insulin and HOMA-IR differed from placebo (5 per group), although baseline insulin was higher in the piceatannol group, and blood pressure and heart rate fell within the piceatannol group; other subgroups showed no benefit, and weight, lipids, inflammation, oxidative stress and endothelial function were unchanged. Morinaga funded the study, supplied the capsules and paid two authors.
  5. Kasai N, Hayashi K, Kito M, Morishima T. Seven days of piceatannol supplementation exerted no effect on fat metabolism at rest, during and after exercise. J Clin Biochem Nutr. 2025;77(1):85-90. doi: 10.3164/jcbn.25-2.PubMedUsed to support: Randomized, double-blind crossover in 8 active men: 10 mg/day of piceatannol (Passienol tablets from Morinaga) or placebo for 7 days. Gas exchange and blood markers of fat use did not differ from placebo at rest, during or after 60 minutes of low-intensity cycling. Funded by university research grants; no conflicts disclosed.
  6. Tanaka K, Kawakami S, Mori S, Yamaguchi T, Saito E, Setoguchi Y, Matsui Y, Nishimura E, Ebihara S, Kawama T. Piceatannol Upregulates SIRT1 Expression in Skeletal Muscle Cells and in Human Whole Blood: In Vitro Assay and a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial. Life (Basel). 2024;14(5):589. doi: 10.3390/life14050589.PubMedUsed to support: Cell experiments plus a randomized, double-blind, placebo-controlled parallel trial (a 200 mL drink, three packs a day supplying 100 mg/day of piceatannol from passion fruit seed extract, for 2 weeks): piceatannol and the seed extract raised SIRT1 in muscle cells, and whole-blood SIRT1 mRNA was higher than with placebo. A laboratory marker. Nine authors were Morinaga employees.
  7. Sousa DF, Araújo MFM, de Mello VD, Damasceno MMC, Freitas RWJF. Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial. J Am Coll Nutr. 2021;40(8):679-688. doi: 10.1080/07315724.2020.1823909.PubMedUsed to support: Randomized, placebo-controlled 120-day trial in 89 people with type 2 diabetes: yellow passion fruit albedo flour (500 mg capsules three times daily) lowered fasting glucose 5.9% versus a 9% rise on placebo, and HbA1c fell 0.8% in both active arms versus placebo (p < 0.05). Turmeric with piperine lowered HOMA-IR and triglycerides more; albedo flour did not lower triglycerides.
  8. de Araújo MFM, Veras VS, de Freitas RWJF, de Paula MDL, de Araújo TM, Uchôa LRA, Gaspar MWG, Cunha MDCDSO, Serra MAAO, Carvalho CML, Costa EC, Damasceno MMC. The effect of flour from the rind of the yellow passion fruit on glycemic control of people with diabetes mellitus type 2: a randomized clinical trial. J Diabetes Metab Disord. 2017;16:18. doi: 10.1186/s40200-017-0300-z.PubMedUsed to support: Open, randomized trial in 54 adults with type 2 diabetes (27 matched pairs): 12 g of yellow passion fruit rind flour before each of three meals for 8 weeks versus usual care did not change capillary glucose, fasting glucose or HbA1c between groups. Funded by Brazil's national research council; retrospectively registered.
  9. Farid R, Rezaieyazdi Z, Mirfeizi Z, Hatef MR, Mirheidari M, Mansouri H, Esmaelli H, Bentley G, Lu Y, Foo Y, Watson RR. Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis. Nutr Res. 2010;30(9):601-6. doi: 10.1016/j.nutres.2010.08.010.PubMedUsed to support: Randomized, double-blind, placebo-controlled trial in 33 adults with knee osteoarthritis: 150 mg/day of purple passion fruit peel extract for 2 months reduced WOMAC pain, stiffness, function and total scores by 18 to 19.6% within the extract group, while scores rose on placebo. No between-group test or funder is given in the abstract; PubMed lists no correction or retraction. Watson RR, Foo Y and Lu Y were inventors on US patent 7,691,423 for this extract.
  10. Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52(3):167-175. doi: 10.1136/bjsports-2016-097333.PubMedUsed to support: Systematic review and meta-analysis of 69 placebo-controlled trials of 20 supplements in osteoarthritis: passion fruit peel extract was one of 7 supplements with large (effect size above 0.80), clinically important short-term pain effects, while the authors noted that supplements with few studies and participants gave such large effects and that overall evidence quality was very low. Full text: only one study (Farid 2010) was included for passion fruit peel extract (pain effect size minus 1.65), and the authors cautioned that this single-trial estimate is likely to change.
  11. Watson RR, Zibadi S, Rafatpanah H, Jabbari F, Ghasemi R, Ghafari J, Afrasiabi H, Foo LY, Faridhosseini R. Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma. Nutr Res. 2008;28(3):166-71. doi: 10.1016/j.nutres.2008.01.003.PubMedUsed to support: Randomized, double-blind, placebo-controlled 4-week trial in adults with asthma: 150 mg/day of purple passion fruit peel extract reduced the prevalence of wheeze, cough and shortness of breath and raised forced vital capacity (P < .05) while placebo did not; FEV1 did not improve and no adverse effects were reported. Results are framed within groups; first author affiliated with a private consulting firm; no funder named in the abstract. Watson RR and Foo LY were inventors on US patent 7,691,423 for this extract.
  12. Brehler R, Theissen U, Mohr C, Luger T. "Latex-fruit syndrome": frequency of cross-reacting IgE antibodies. Allergy. 1997;52(4):404-10. doi: 10.1111/j.1398-9995.1997.tb01019.x.PubMedUsed to support: Serum study of 136 patients with clinically relevant latex allergy: fruit-specific IgE was found in 69.1%, cross-reacting IgE recognizing latex and fruit allergens (including passion fruit) was shown by RAST inhibition, and 42.5% reported allergic symptoms after eating these fruits.
  13. Seigler DS, Pauli GF, Nahrstedt A, Leen R. Cyanogenic allosides and glucosides from Passiflora edulis and Carica papaya. Phytochemistry. 2002;60(8):873-82. doi: 10.1016/s0031-9422(02)00170-x.PubMedUsed to support: Chemistry study: leaf and stem material of Passiflora edulis contains several cyanogenic glycosides, and the major cyanogens of the fruits are (2R)-prunasin and (2S)-sambunigrin.
  14. Yang J, Zheng L, Liao Y, Fu Y, Zeng D, Chen W, Wu W. HCN-induced embryo arrest: passion fruit as an ecological trap for fruit flies. Pest Manag Sci. 2023;79(6):2172-2181. doi: 10.1002/ps.7396.PubMedUsed to support: Field and laboratory study in southern China: when fruit flies pierce passion fruits to lay eggs, hydrogen cyanide is released from the cyanogenic mesocarp (inner peel), and the eggs fail to hatch. Not a human study; cited to show that the peel tissue is cyanogenic.
  15. Lewis BJ, Herrlinger KA, Craig TA, Mehring-Franklin CE, Defreitas Z, Hinojosa-Laborde C. Antihypertensive effect of passion fruit peel extract and its major bioactive components following acute supplementation in spontaneously hypertensive rats. J Nutr Biochem. 2013;24(7):1359-66. doi: 10.1016/j.jnutbio.2012.11.003.PubMedUsed to support: Rat study with telemetry: single oral doses of Passiflora edulis peel extract at 50 mg/kg (the lowest effective dose) lowered hemodynamic measures versus control in spontaneously hypertensive rats; edulilic acid and an anthocyanin fraction did the same, while GABA did not and raised heart rate. First author's contact address is at Kemin. Not a human study.
  16. Yapo BM, Koffi KL. Dietary fiber components in yellow passion fruit rind--a potential fiber source. J Agric Food Chem. 2008;56(14):5880-3. doi: 10.1021/jf073247p.PubMedUsed to support: Laboratory composition study: total dietary fiber in the alcohol-insoluble material of yellow passion fruit rind was above 73% of dry matter, with insoluble fiber above 60%, and the material held more than 3 g of water and 4 g of oil per gram. No human participants.
  17. Foo LY, Lu Y, Watson RR. Method of treating inflammation disorders using extracts of passion fruit (US Patent 7,691,423 B2). United States Patent and Trademark Office. 2010;US 7,691,423 B2; priority date 2005-04-04; granted 2010-04-06; assignees Industrial Research Ltd and Southwest Scientific Editing and Consulting LLC..SourceUsed to support: Not PubMed-indexed. Patent whose claims cover easing asthma or osteoarthritis symptoms with a water extract of passion fruit peel; the inventors are authors of the asthma and knee trials cited here, and one assignee is the consulting firm listed as the first author's affiliation in the asthma trial. Its description reports 44 enrolled and 42 completing in the asthma study and 17 extract versus 16 placebo in the knee study.