Osteol® (Olive Polyphenol Extract)

Olea europaea
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Osteol® is a standardized olive (Olea europaea) polyphenol extract studied for bone health. In a twelve-month clinical trial, an olive polyphenol extract raised a marker of bone formation and improved cholesterol in postmenopausal women with low bone density, supporting its positioning for bone and cardiovascular health.

Studied Dose Around 250 mg of olive polyphenols per day in studies.
Active Compound Standardized olive polyphenol extract concentrated for oleuropein and hydroxytyrosol.

Benefits

Bone formation

In a 12-month randomized trial, olive polyphenol extract increased serum osteocalcin, a marker of bone formation, in postmenopausal women with osteopenia.

Heart health

The same trial found improvements in serum lipid profiles, reflecting the cardiovascular benefits of olive polyphenols.

Antioxidant support

Oleuropein and hydroxytyrosol are powerful antioxidants that protect bone and blood-vessel tissue from oxidative stress.

Mechanism of action

1

Bone-cell signaling

Olive polyphenols support the activity of bone-building osteoblasts and help balance bone remodeling, favoring formation.

2

Antioxidant and anti-inflammatory action

By lowering oxidative stress and inflammation, olive polyphenols protect both bone and the cardiovascular system.

Clinical trials

1
Olive Polyphenols and Bone — 12-Month RCT
PubMed

Twelve-month double-blind randomized trial of an olive polyphenol extract in postmenopausal women with osteopenia. (Filip et al. 2015, Journal of Nutrition, Health and Aging)

Postmenopausal women with osteopenia.

Olive polyphenol extract increased serum osteocalcin (bone formation) and improved lipid profiles versus placebo.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Blood pressure or anticoagulant medication — olive polyphenols may have additive effects; monitor.
Generally compatible with a healthy diet.
Tell your doctor if you take cardiovascular medication.

Frequently asked questions about Osteol® (Olive Polyphenol Extract)

What is Osteol?

Osteol® is a standardized olive (Olea europaea) polyphenol extract studied for bone health. In a twelve-month clinical trial, an olive polyphenol extract raised a marker of bone formation and improved cholesterol in postmenopausal women with low bone density, supporting its positioning for bone and cardiovascular healt…

What is Osteol used for?

Osteol is researched primarily for Bone Health and Cardiovascular. In a 12-month randomized trial, olive polyphenol extract increased serum osteocalcin, a marker of bone formation, in postmenopausal women with osteopenia.

What is the recommended dosage of Osteol?

The clinically studied dose is Around 250 mg of olive polyphenols per day in studies. Always follow the product label and check with a healthcare provider for personal advice.

Is Osteol safe, and does it have side effects?

For most healthy adults, Osteol is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. It may also interact with some medications. Osteol is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Osteol interact with any medications?

Possible interactions include: Blood pressure or anticoagulant medication — olive polyphenols may have additive effects; monitor. Generally compatible with a healthy diet. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Osteol?

NutraSmarts rates the evidence for Osteol as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Filip R, Possemiers S, Heyerick A, et al. Twelve-month consumption of a polyphenol extract from olive (Olea europaea) in a double blind, randomized trial increases serum total osteocalcin levels and improves serum lipid profiles in postmenopausal women with osteopenia. J Nutr Health Aging. 2015;19(1):77-86..PubMedUsed to support: RCT supporting bone-formation and lipid benefit of olive polyphenols.