Home Ingredients NeuGrape® (Grape Seed Extract for Cognition)
CognitiveAntioxidant

NeuGrape® (Grape Seed Extract for Cognition)

Vitis vinifera
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

NeuGrape® is a grape (Vitis vinifera) seed extract concentrated for oligomeric proanthocyanidins (OPCs), studied for supporting brain health. Grape polyphenols are potent antioxidants that protect neurons and support blood flow to the brain, the basis for NeuGrape's cognitive positioning.

Studied Dose Commonly 100 to 300 mg per day.
Active Compound Grape seed extract concentrated for oligomeric proanthocyanidins (OPCs).

Benefits

Cognitive support

Grape seed proanthocyanidins are studied for supporting cognitive function and protecting the brain from oxidative stress.

Supported by Trial 1

Antioxidant defense

Grape OPCs are potent antioxidants that protect neurons and blood vessels from free-radical damage.

Supported by Trial 1

Brain blood flow

By supporting healthy blood-vessel function, grape polyphenols support circulation to the brain.

Supported by Trial 1

Mechanism of action

1

Proanthocyanidin neuroprotection

Grape OPCs scavenge free radicals and support antioxidant defenses in brain tissue, protecting neurons from oxidative stress.

2

Vascular support

Grape polyphenols support nitric-oxide-mediated blood-vessel relaxation, aiding blood flow to the brain.

Clinical trials

1
Grape Proanthocyanidins and Oxidative Stress — Study
PubMed

Study of a grape seed proanthocyanidin extract on oxidative stress and vascular markers. (Kalin et al. 2002, Free Radical Research)

Adults.

The grape proanthocyanidin extract reduced markers of oxidative stress and vascular inflammation, relevant to neuroprotection.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape OPCs may have a mild additive effect; monitor.
Blood pressure medication — possible additive effect; monitor.
Tell your doctor before surgery.

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Frequently asked questions about NeuGrape® (Grape Seed Extract for Cognition)

What is NeuGrape?

NeuGrape® is a grape (Vitis vinifera) seed extract concentrated for oligomeric proanthocyanidins (OPCs), studied for supporting brain health. Grape polyphenols are potent antioxidants that protect neurons and support blood flow to the brain, the basis for NeuGrape's cognitive positioning.

What is NeuGrape used for?

NeuGrape is researched primarily for Cognitive and Antioxidant. Grape seed proanthocyanidins are studied for supporting cognitive function and protecting the brain from oxidative stress.

What is the recommended dosage of NeuGrape?

The clinically studied dose is Commonly 100 to 300 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is NeuGrape safe, and does it have side effects?

For most healthy adults, NeuGrape is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. It may also interact with some medications. NeuGrape is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does NeuGrape interact with any medications?

Possible interactions include: Anticoagulants — grape OPCs may have a mild additive effect; monitor. Blood pressure medication — possible additive effect; monitor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for NeuGrape?

NutraSmarts rates the evidence for NeuGrape as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Kalin R, Righi A, Del Rosso A, et al. Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic Res. 2002;36(8):819-25..PubMedUsed to support: Study supporting antioxidant and vascular benefit of grape proanthocyanidins.