Home Ingredients NaturSYN® Defense (Rye and Oyster Mushroom Blend)
Anti-Inflammatory

NaturSYN® Defense (Rye and Oyster Mushroom Blend)

Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

NaturSYN® Defense is a proprietary blend sold to supplement manufacturers by Nutraceuticals International Group. The supplier describes it as amino acids from rye (Secale cereale L.) combined with polysaccharides from oyster mushroom (Pleurotus ostreatus), and does not publish how much of either it contains. No clinical trial of the blend has been published and none is registered, so there is no human evidence about what it does.

Studied Dose No dose is published. No amount of this blend has been tested in people, and the supplier publishes no recommended intake, so whatever appears in a finished product is set by that brand alone.
Active Compound Amino acids from rye (Secale cereale L.) and polysaccharides from oyster mushroom (Pleurotus ostreatus). Rye is a gluten-containing grain and the supplier publishes no gluten or allergen testing for the blend.

Benefits

Inflammatory mediators: laboratory testing only

The supplier states that the blend was tested in inflammatory models and that the testing showed an ability to modulate pro-inflammatory mediators. That testing has never been published, so its design, its comparison and its results cannot be checked by anyone outside the company. Models in a laboratory are not people: no study has measured inflammation in a single person taking this blend.

Allergy and stress: nothing measured

Trade marketing for the blend describes calming the overreaction seen with allergies and stress, but no study has recorded allergy symptoms, a stress marker, or any related outcome in people taking it. A separate beta-glucan isolated from oyster mushroom (pleuran) lowered blood eosinophil counts in one placebo-controlled trial in children; the supplier does not say the blend contains it. Allergy is diagnosed and treated by a clinician.

What the evidence actually is

There is no published human evidence on this blend: not thin evidence, none. Searches of PubMed, Europe PMC, CrossRef and ClinicalTrials.gov return no study of NaturSYN Defense and no registered trial, and the NIH Dietary Supplement Label Database lists no product containing it. The only evidence anyone points to for the blend itself is unpublished laboratory model work described by the supplier.

Mechanism of action

1

Inflammatory-mediator modulation

The supplier's proposed mechanism is that the blend modulates the release of cytokines in irritated tissue or mucosa. This is a proposal resting on unpublished laboratory work, not a demonstrated action in people, and nothing published shows what survives digestion or reaches the bloodstream after a capsule is swallowed.

2

Mushroom polysaccharides and the film-forming claim

The blend's other described component is polysaccharide material from oyster mushroom, which the supplier credits with forming a protective film on damaged tissue and with immune modulation. A film needs direct contact with tissue, which a swallowed capsule has only along the digestive tract. Beta-glucan isolated from oyster mushroom (pleuran) has shifted some immune cell measures in placebo-controlled trials, but neither the film nor any immune effect has been measured in a person taking this product.

Clinical trials

Side effects and drug interactions

Common Potential side effects

No safety or tolerability study of this blend has been published, so its side-effect profile in people is unknown; a review of 34 trials of oral fungal beta-glucans (not this blend) recorded no adverse event attributed to them.
The starting materials are rye, a gluten-containing grain, and oyster mushroom; anyone with a rye or mushroom allergy, or who avoids gluten, should treat a product containing it as a possible source unless that product publishes allergen testing.
Discontinue if any unusual reaction occurs.

Important Drug interactions

No drug interaction has been established for this blend because none has been looked for. Nothing has been tested, so an absence of reports says nothing about safety alongside medication.
Tell your doctor about all supplements if you take prescription medication.
There are no data in pregnancy, breastfeeding, children, or people managing a medical condition. In those situations treat the absence of data as a reason to avoid it, not as reassurance.

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Frequently asked questions about NaturSYN® Defense (Rye and Oyster Mushroom Blend)

What is NaturSYN Defense?

NaturSYN® Defense is a proprietary blend sold to supplement manufacturers by Nutraceuticals International Group. The supplier describes it as amino acids from rye (Secale cereale L.) combined with polysaccharides from oyster mushroom (Pleurotus ostreatus), and does not publish how much of either it contains.

What is NaturSYN Defense used for?

NaturSYN Defense is researched primarily for Anti-Inflammatory. The supplier states that the blend was tested in inflammatory models and that the testing showed an ability to modulate pro-inflammatory mediators.

What is the recommended dosage of NaturSYN Defense?

No dose is published. No amount of this blend has been tested in people, and the supplier publishes no recommended intake, so whatever appears in a finished product is set by that brand alone. Always follow the product label and check with a healthcare provider for personal advice.

Is NaturSYN Defense safe, and does it have side effects?

Side effects and cautions reported for NaturSYN Defense include: No safety or tolerability study of this blend has been published, so its side-effect profile in people is unknown; a review of 34 trials of oral fungal beta-glucans (not this blend) recorded no adverse event attributed to them. It may also interact with some medications. NaturSYN Defense is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does NaturSYN Defense interact with any medications?

Possible interactions include: No drug interaction has been established for this blend because none has been looked for. Nothing has been tested, so an absence of reports says nothing about safety alongside medication. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for NaturSYN Defense?

NutraSmarts rates the evidence for NaturSYN Defense as Preliminary (1 out of 5). It is backed by 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Jesenak M, Hrubisko M, Majtan J, Rennerova Z, Banovcin P. Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Phytother Res. 2014;28(3):471-4..PubMedUsed to support: Randomised, double-blind, placebo-controlled trial in children with recurrent respiratory tract infections: pleuran, an insoluble beta-glucan isolated from oyster mushroom (Pleurotus ostreatus), significantly reduced peripheral blood eosinophilia and stabilised serum total IgE, more evidently in atopic children. It tested pleuran, not NaturSYN Defense; the supplier does not state that its blend contains pleuran or how much polysaccharide it holds.
  2. Bergendiova K, Tibenska E, Majtan J. Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur J Appl Physiol. 2011;111(9):2033-40..PubMedUsed to support: Double-blind, placebo-controlled trial in 50 athletes under heavy training: 3 months of pleuran (Imunoglukan), an insoluble beta-(1,3/1,6)-glucan from oyster mushroom, reduced the incidence of upper respiratory tract infection symptoms and increased circulating NK cells, and phagocytosis stayed stable while it fell in the placebo group. It tested a separate commercial oyster mushroom beta-glucan, not this blend.
  3. Vlassopoulou M, Yannakoulia M, Pletsa V, Zervakis GI, Kyriacou A. Effects of fungal beta-glucans on health - a systematic review of randomized controlled trials. Food Funct. 2021;12(8):3366-3380..PubMedUsed to support: Systematic review of 34 randomized controlled trials of oral fungal beta-(1,3/1,6)-glucans (from yeast, Aureobasidium pullulans, Pleurotus ostreatus, shiitake and reishi; 2.5 to 1000 mg daily for up to 6.5 months): the main outcome was immunomodulation, including fewer cold and respiratory infection symptoms and improved allergic symptoms, though cellular and molecular immune findings were inconsistent, and no adverse event causally related to glucans was recorded. None of the trials tested this blend.
  4. Tye-Din JA, Stewart JA, Dromey JA, Beissbarth T, van Heel DA, Tatham A, Henderson K, Mannering SI, Gianfrani C, Jewell DP, Hill AV, McCluskey J, Rossjohn J, Anderson RP. Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Sci Transl Med. 2010;2(41):41ra51..PubMedUsed to support: Celiac patients who ate rye, like those who ate wheat or barley, developed gluten-specific T cells in blood, and rye prolamins were included among the celiac-toxic cereal proteins mapped; this supports the page's note that rye is a gluten-containing grain. It did not test this blend or rye-derived amino acid preparations.