Home Ingredients Natavid® (Whole Grapevine Extract — Natac)
CardiovascularAntioxidant

Natavid® (Whole Grapevine Extract — Natac)

Vitis vinifera
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

Natavid® is a whole-grapevine (Vitis vinifera) extract from Natac that captures the full plant profile, combining vine leaves, grape seeds, and grape skin in one standardized extract rich in proanthocyanidins. It is positioned to support vein health, healthy circulation, and antioxidant defense.

Studied Dose Per the product specification.
Active Compound Whole-grapevine extract standardized to about 50% proanthocyanidins, with flavonoids and resveratrol or anthocyanins.

Benefits

Vein and circulation support

Grapevine proanthocyanidins are traditionally used to support vein tone and healthy circulation, of interest for tired, heavy legs.

Supported by Trial 1

Antioxidant defense

Grapevine polyphenols act as antioxidants; the available human data come from a grape seed extract that reduced LDL cholesterol's susceptibility to oxidation in smokers, a different preparation than whole-grapevine extract.

Supported by Trial 1

Cardiovascular support

By supporting blood-vessel health and reducing oxidative stress, grapevine polyphenols support cardiovascular wellness.

Supported by Trial 1

Mechanism of action

1

Vascular protection

Grape proanthocyanidins support the integrity and tone of blood-vessel and capillary walls, aiding healthy venous return.

2

Free-radical scavenging

The polyphenols neutralize free radicals and protect LDL cholesterol and vessel linings from oxidation.

Clinical trials

1
Grape Seed Extract and LDL Oxidation — Trial
PubMed

Trial of a standardized grape seed extract, in heavy smokers, on LDL cholesterol's susceptibility to oxidation. (Vigna et al. 2003, Metabolism)

Heavy smokers (adults).

The standardized grape seed extract reduced LDL cholesterol's susceptibility to oxidation, reflecting the antioxidant value of grape polyphenols; note this study used a grape seed extract, a different preparation than the whole-grapevine (leaves, seeds, and skin) Natavid extract.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild digestive upset or headache is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape polyphenols may have a mild additive effect; monitor.
Blood pressure medication — possible mild additive effect; monitor.
Tell your doctor before surgery.

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Frequently asked questions about Natavid® (Whole Grapevine Extract — Natac)

What is Natavid?

Natavid® is a whole-grapevine (Vitis vinifera) extract from Natac that captures the full plant profile, combining vine leaves, grape seeds, and grape skin in one standardized extract rich in proanthocyanidins. It is positioned to support vein health, healthy circulation, and antioxidant defense.

What is Natavid used for?

Natavid is researched primarily for Cardiovascular and Antioxidant. Grapevine proanthocyanidins are traditionally used to support vein tone and healthy circulation, of interest for tired, heavy legs.

What is the recommended dosage of Natavid?

The clinically studied dose is Per the product specification. Always follow the product label and check with a healthcare provider for personal advice.

Is Natavid safe, and does it have side effects?

For most healthy adults, Natavid is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild digestive upset or headache is occasionally reported. It may also interact with some medications. Natavid is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Natavid interact with any medications?

Possible interactions include: Anticoagulants — grape polyphenols may have a mild additive effect; monitor. Blood pressure medication — possible mild additive effect; monitor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Natavid?

NutraSmarts rates the evidence for Natavid as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Vigna GB, Costantini F, Aldini G, et al. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism. 2003;52(10):1250-7..PubMedUsed to support: Trial in heavy smokers supporting the antioxidant action of grape polyphenols; this study used a grape seed extract, a different preparation than the whole-grapevine Natavid extract.