Benefits
Slower epigenetic aging and lower cortisol (branded RCT)
In a randomized, double-blind, placebo-controlled trial in stressed workers (45–65 y), 100 mg/day reduced the gain in a biological-age (epigenetic) measure and lowered cortisol versus placebo, with improvements in quality of life and sleep. A novel endpoint; needs replication.
Stress and sleep support
Lower cortisol and reported sleep improvements suggest stress-axis modulation, the likely route to the wellbeing and sleep benefits.
Didymin flavonoid healthy-aging signaling
Didymin engages cellular stress-response and longevity pathways in laboratory models, the mechanistic basis for the geroprotective positioning.
Mechanism of action
Cortisol / stress-axis modulation
Reducing cortisol output eases a key driver of stress-related aging, sleep disruption and metabolic strain.
Epigenetic / longevity-pathway signaling
Didymin influences AMPK/FOXO-type stress-response signaling associated with cellular healthy-aging in preclinical work.
Clinical trials
In vitro plus randomized, double-blind, placebo-controlled human trial, 100 mg/day for 12 weeks (GeroScience, 2025).
81 stressed workers aged 45–65
Smaller biological-age gain (0.3 vs 1.8 years), ~25% lower cortisol, and improved quality of life/sleep versus placebo. Manufacturer-associated; novel endpoint.