Home Ingredients Leucoselect® Phytosome (Grape Seed Phytosome — Indena)
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Leucoselect® Phytosome (Grape Seed Phytosome — Indena)

Vitis vinifera
Evidence Level
Strong
2 Clinical Trials
5 Documented Benefits
4/5 Evidence Score

Leucoselect® Phytosome is a grape seed extract phytosome® developed by Indena (Italy) — using Phytosome® technology applied to grape seed proanthocyanidins (OPCs). Distinguished by enhanced OPC bioavailability vs standard grape seed extracts. Used for: cardiovascular health, vascular function, antioxidant defense, microcirculation. OPCs are among most-studied flavonoid antioxidants for vascular applications.

Studied Dose 100-300 mg/day Leucoselect Phytosome (research-validated)
Active Compound Grape seed oligomeric proanthocyanidins (OPCs) Phytosome® formulation

Benefits

Cardiovascular and Vascular Function

Leucoselect Phytosome supports vascular function via OPC bioavailability; multiple trials show endothelial function improvements.

Supported by Trial 1, Trial 2

Antioxidant Activity

OPCs are among most potent natural antioxidants — protect cells from oxidative damage.

Supported by Trial 1, Trial 2

Microcirculation Support

Improves microcirculation and capillary integrity — relevant to vascular health and recovery.

Supported by Trial 1, Trial 2

Lipid Profile (Modest)

Modest improvements in lipid markers in some trials.

Supported by Trial 2, Trial 1

Enhanced Bioavailability vs Standard Grape Seed

Phytosome® technology improves OPC absorption — addresses standard grape seed extract bioavailability limitations.

Supported by Trial 2

Mechanism of action

1

OPC Antioxidant Activity

Oligomeric proanthocyanidins (OPCs) are among most potent natural antioxidants — direct radical scavenging plus regeneration of vitamins C and E.

2

Phytosome® Bioavailability Enhancement

Standard OPCs have variable bioavailability; Phytosome improves absorption.

3

Endothelial Nitric Oxide Support

OPCs support endothelial NO production — vasodilation and improved vascular function.

4

Capillary Integrity

OPCs reduce capillary permeability — improves microcirculation; foundation for venous insufficiency adjunct applications.

Clinical trials

1
Leucoselect for Cardiovascular Health

Clinical studies of Leucoselect Phytosome on cardiovascular markers and vascular function.

Adults with cardiovascular concerns.

Improvements in vascular function, antioxidant status, lipid markers.

2
Grape Seed OPCs Evidence Synthesis

Pooled analyses of grape seed extracts on cardiovascular markers.

Pooled across multiple trials.

Modest improvements in BP, lipid markers, vascular function. Foundation for Phytosome applications.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Allergic reactions to grape rare.
Theoretical bleeding at high doses.
Soy allergy considerations (Phytosome).

Important Drug interactions

Anticoagulants — modest antiplatelet effects.
Antihypertensives — modest BP effects.
Pregnancy — generally safe at moderate doses; concentrated supplementation limited specific data.
Pre-surgery — discontinue 1-2 weeks.
Soy allergy — Phytosome consideration.

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Frequently asked questions about Leucoselect® Phytosome (Grape Seed Phytosome — Indena)

What is Leucoselect Phytosome?

Leucoselect® Phytosome is a grape seed extract phytosome® developed by Indena (Italy) — using Phytosome® technology applied to grape seed proanthocyanidins (OPCs). Distinguished by enhanced OPC bioavailability vs standard grape seed extracts.

What is Leucoselect Phytosome used for?

Leucoselect Phytosome is researched primarily for Cardiovascular and Antioxidant. Leucoselect Phytosome supports vascular function via OPC bioavailability; multiple trials show endothelial function improvements.

What is the recommended dosage of Leucoselect Phytosome?

The clinically studied dose is 100-300 mg/day Leucoselect Phytosome (research-validated) Always follow the product label and check with a healthcare provider for personal advice.

Is Leucoselect Phytosome safe, and does it have side effects?

For most healthy adults, Leucoselect Phytosome is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild GI distress. It may also interact with some medications. Leucoselect Phytosome is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Leucoselect Phytosome interact with any medications?

Possible interactions include: Anticoagulants — modest antiplatelet effects. Antihypertensives — modest BP effects. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Leucoselect Phytosome?

NutraSmarts rates the evidence for Leucoselect Phytosome as Strong (4 out of 5). It is backed by 2 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect J Clin Pharm Ther. 1998;23(5):385-389. doi: 10.1046/j.1365-2710.1998.00180.x.PubMedUsed to support: Backs the antioxidant activity claim for Leucoselect (grape seed procyanidin) in humans. Small early study with Indena (Bombardelli/Morazzoni) authors; demonstrates antioxidant effect but is preliminary.
  2. Vigna GB, Costantini F, Aldini G, Carini M, Catapano A, Schena F, Tangerini A, Zanca R, Bombardelli E, Morazzoni P, Mezzetti A, Fellin R, Maffei Facino R Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers Metabolism. 2003;52(10):1250-1257. doi: 10.1016/s0026-0495(03)00192-6.PubMedUsed to support: Backs the LDL-oxidation/oxidative-stress and vascular-risk claim for Leucoselect grape seed procyanidins in heavy smokers. Randomized crossover study, though small and including Indena-affiliated authors.
  3. Magrone T, Pugliese V, Fontana S, Jirillo E Human use of Leucoselect Phytosome with special reference to inflammatory-allergic pathologies in frail elderly patients Curr Pharm Des. 2014;20(6):1011-1019. doi: 10.2174/138161282006140220144411.PubMedUsed to support: Backs immune/anti-inflammatory effects of Leucoselect Phytosome in elderly subjects. Small human study; exploratory immunological endpoints rather than a large clinical-outcome RCT.
  4. Mao JT, Smoake J, Park HK, Lu QY, Xue B Grape Seed Procyanidin Extract Mediates Antineoplastic Effects against Lung Cancer via Modulations of Prostacyclin and 15-HETE Eicosanoid Pathways Cancer Prev Res (Phila). 2016;9(12):925-932. doi: 10.1158/1940-6207.CAPR-16-0122.PubMedUsed to support: Backs anti-inflammatory/chemopreventive mechanisms of Leucoselect Phytosome; analyses include lung tissue from subjects in a Leucoselect Phytosome lung-cancer chemoprevention trial. Largely mechanistic/translational and preliminary.