Home Ingredients GlycOmega-PLUS® (Green-Lipped Mussel)
Joint Health

GlycOmega-PLUS® (Green-Lipped Mussel)

Perna canaliculus
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

GlycOmega-plus® is a green-lipped mussel (Perna canaliculus) powder from New Zealand, a marine source of omega-3 fatty acids and glycosaminoglycans studied for joint health. The unique marine omega-3 profile and joint-supporting compounds make it a popular natural option for joint comfort.

Studied Dose Commonly around 1000 to 3000 mg of mussel powder per day.
Active Compound Green-lipped mussel (Perna canaliculus) powder, providing marine omega-3 fatty acids and glycosaminoglycans.

Benefits

Joint comfort

A systematic review of trials found green-lipped mussel extract supported improvements in osteoarthritis symptoms, consistent with its joint-comfort positioning.

Supported by Trial 1

Anti-inflammatory marine omega-3s

Green-lipped mussel supplies distinctive marine omega-3 fatty acids that help calm joint inflammation.

Supported by Trial 1

Cartilage-supporting compounds

The mussel provides glycosaminoglycans, building blocks related to those in joint cartilage and fluid.

Supported by Trial 1

Mechanism of action

1

Marine omega-3 action

Green-lipped mussel's unique fatty acids inhibit inflammatory pathways (such as lipoxygenase) involved in joint pain and swelling.

2

Glycosaminoglycan support

The mussel's natural glycosaminoglycans support the cartilage and lubricating fluid of the joint.

Clinical trials

1
Green-Lipped Mussel and Osteoarthritis — Systematic Review
PubMed

Systematic review of green-lipped mussel (Perna canaliculus) extract in the treatment of osteoarthritis. (Abshirini et al. 2021, Inflammopharmacology)

Adults with osteoarthritis across trials.

Green-lipped mussel extract supported improvements in osteoarthritis symptoms, though larger trials are warranted.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — digestive symptoms are most common.
Mild stomach upset is occasionally reported.
Avoid if you have a shellfish allergy.

Important Drug interactions

Anticoagulants — marine omega-3s may have a mild additive effect; monitor.
Tell your doctor if you have a shellfish allergy or take blood thinners.
Consult a doctor if pregnant or breastfeeding.

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Frequently asked questions about GlycOmega-PLUS® (Green-Lipped Mussel)

What is GlycOmega-PLUS?

GlycOmega-plus® is a green-lipped mussel (Perna canaliculus) powder from New Zealand, a marine source of omega-3 fatty acids and glycosaminoglycans studied for joint health. The unique marine omega-3 profile and joint-supporting compounds make it a popular natural option for joint comfort.

What is GlycOmega-PLUS used for?

GlycOmega-PLUS is researched primarily for Joint Health. A systematic review of trials found green-lipped mussel extract supported improvements in osteoarthritis symptoms, consistent with its joint-comfort positioning.

What is the recommended dosage of GlycOmega-PLUS?

The clinically studied dose is Commonly around 1000 to 3000 mg of mussel powder per day. Always follow the product label and check with a healthcare provider for personal advice.

Is GlycOmega-PLUS safe, and does it have side effects?

For most healthy adults, GlycOmega-PLUS is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — digestive symptoms are most common. Mild stomach upset is occasionally reported. It may also interact with some medications. GlycOmega-PLUS is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does GlycOmega-PLUS interact with any medications?

Possible interactions include: Anticoagulants — marine omega-3s may have a mild additive effect; monitor. Tell your doctor if you have a shellfish allergy or take blood thinners. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for GlycOmega-PLUS?

NutraSmarts rates the evidence for GlycOmega-PLUS as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Abshirini M, Coad J, Wolber FM, et al. Green-lipped (greenshell) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review. Inflammopharmacology. 2021;29(4):925-938..PubMedUsed to support: Systematic review supporting joint benefit of green-lipped mussel.