Home Ingredients FitGrape® (Grape Polyphenol Extract)
AntioxidantCardiovascular

FitGrape® (Grape Polyphenol Extract)

Vitis vinifera
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

FitGrape® is a grape (Vitis vinifera) extract concentrated for polyphenols, including the oligomeric proanthocyanidins (OPCs) that make grape one of the richest plant antioxidant sources. Grape polyphenols are studied for supporting blood-vessel health and antioxidant defense.

Studied Dose Commonly 100 to 300 mg per day.
Active Compound Grape extract concentrated for polyphenols and oligomeric proanthocyanidins (OPCs).

Benefits

Antioxidant defense

Grape polyphenols are potent antioxidants; in a clinical study, a grape proanthocyanidin extract reduced markers of oxidative stress and vascular inflammation.

Supported by Trial 1

Vascular support

By lowering oxidative stress, grape polyphenols support healthy blood-vessel function and circulation.

Supported by Trial 1

Cellular protection

The OPCs help protect cells and tissues from free-radical damage.

Mechanism of action

1

Proanthocyanidin antioxidants

Grape OPCs neutralize free radicals and support the body's antioxidant enzymes, protecting blood vessels and tissues.

2

Vascular signaling

Grape polyphenols support nitric-oxide-mediated blood-vessel relaxation and healthy circulation.

Clinical trials

1
Grape Proanthocyanidins and Oxidative Stress — Study
PubMed

Study of a grape seed proanthocyanidin extract on oxidative stress and vascular adhesion molecules. (Kalin et al. 2002, Free Radical Research)

Adults.

The grape proanthocyanidin extract reduced markers of oxidative stress and vascular adhesion molecules.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape polyphenols may have a mild additive effect; monitor.
Blood pressure medication — possible additive effect; monitor.
Tell your doctor before surgery.

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Frequently asked questions about FitGrape® (Grape Polyphenol Extract)

What is FitGrape?

FitGrape® is a grape (Vitis vinifera) extract concentrated for polyphenols, including the oligomeric proanthocyanidins (OPCs) that make grape one of the richest plant antioxidant sources. Grape polyphenols are studied for supporting blood-vessel health and antioxidant defense.

What is FitGrape used for?

FitGrape is researched primarily for Antioxidant and Cardiovascular. Grape polyphenols are potent antioxidants; in a clinical study, a grape proanthocyanidin extract reduced markers of oxidative stress and vascular inflammation.

What is the recommended dosage of FitGrape?

The clinically studied dose is Commonly 100 to 300 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is FitGrape safe, and does it have side effects?

For most healthy adults, FitGrape is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild digestive upset is occasionally reported. It may also interact with some medications. FitGrape is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does FitGrape interact with any medications?

Possible interactions include: Anticoagulants — grape polyphenols may have a mild additive effect; monitor. Blood pressure medication — possible additive effect; monitor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for FitGrape?

NutraSmarts rates the evidence for FitGrape as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Kalin R, Righi A, Del Rosso A, et al. Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic Res. 2002;36(8):819-25..PubMedUsed to support: Study supporting antioxidant and vascular benefit of grape proanthocyanidins.