Home Ingredients Fisetin
Longevity

Fisetin

Evidence Level
Preliminary
2 Clinical Trials
2 Documented Benefits
1/5 Evidence Score

Fisetin is a flavonoid found in small amounts in fruits and vegetables such as apples, persimmons, grapes, onions and cucumbers, with higher levels in strawberries. It is studied in longevity research as a possible senolytic, a compound that removes senescent cells, which stop dividing and build up with age. In a laboratory screen of 10 flavonoids, fisetin was the most active against senescent cells, and in mice it lowered senescence markers and extended median and maximum lifespan when started late in life. None of this has been shown in people yet. A placebo-controlled Mayo Clinic trial in older adults using 20 mg/kg on 2 consecutive days has not posted results. Two small randomized trials gave 200 mg/day for 12 weeks to men with obesity, with or without exercise, and measured inflammation and blood sugar markers, not aging.

Studied Dose 200 mg/day for 12 weeks in small trials in men with obesity. A registered frailty trial uses 20 mg/kg/day on 2 consecutive days; that regimen comes from mouse research, and the trial has not posted results.
Active Compound Fisetin (3,3',4',7-tetrahydroxyflavone).

Benefits

Senolytic activity in cells and aged mice

In a screen of 10 flavonoids, fisetin was the most active against senescent cells in culture. In mice, it lowered senescence markers in several tissues and, started late in life, extended median and maximum lifespan. Whether it clears senescent cells or slows aging in people has not been shown.

Supported by Trial 1

Inflammation markers in men with obesity

In a 12-week randomized trial in 44 men with obesity, 200 mg/day of fisetin lowered IL-6 and TNF-alpha, and fasting glucose, insulin and HOMA-IR also fell in all active groups, with the largest changes when fisetin was combined with exercise. This is one small trial measuring blood markers only.

Supported by Trial 1, Trial 2

Mechanism of action

1

Targeting senescent cells

Senescent cells stop dividing and release inflammatory signals that are thought to contribute to age-related chronic disease. In laboratory and mouse work, fisetin reduced senescence markers in a subset of cell types, including in human fat tissue samples treated outside the body. The exact pathways involved in people are not established.

2

Inflammatory signalling

Signals released by senescent cells are thought to add to low-grade inflammation with age. In one small human trial, fisetin lowered IL-6 and TNF-alpha, but senescent cells were not measured, so the two findings have not been linked in people.

Clinical trials

1
Fisetin with or without exercise in men with obesity
PubMed

12-week randomized controlled trial with four groups: placebo, fisetin 200 mg/day, exercise with placebo, and exercise with fisetin. (Alipour et al. 2026, J Int Soc Sports Nutr)

44 adult men with obesity (BMI over 30).

IL-6 fell in the fisetin-only, exercise and combined groups, and TNF-alpha, fasting glucose, insulin and HOMA-IR fell in all active groups, with the largest changes when fisetin was combined with exercise. Senescent cells and aging outcomes were not measured.

2
Fisetin and exercise: adipokines in men with obesity
PubMed

12-week double-blind randomized trial with the same four-group design: placebo, fisetin 200 mg/day, exercise with placebo, and exercise with fisetin. (Alipour et al. 2026, Nutrients)

60 sedentary men with obesity.

All three active groups lost more weight than placebo. The combined group had the largest falls in asprosin and MCP-1 and the clearest lipid improvements.

Side effects and drug interactions

Common Potential side effects

The two trials in men with obesity were small and lasted 12 weeks; long-term and high-dose safety in people has not been established.
Safety of high intermittent doses, such as 20 mg/kg on 2 consecutive days, is not established.

Important Drug interactions

Interactions with fisetin supplements have not been studied in people.
People taking prescription medicines, including blood thinners, diabetes medicines or cancer treatment, should ask a doctor or pharmacist before use, especially at high doses.

More Longevity Ingredients

Longevity
Veri-te™ Resveratrol (Evolva)
Veri-te™ is a branded trans-resveratrol from Evolva (Switzerland). The supplier states it…
Longevity
Pterostilbene
Pterostilbene is a methylated analog of resveratrol — found primarily in blueberries, cran…
Longevity
GlyNAC (Glycine + N-Acetylcysteine)
GlyNAC is a combination of the amino acid glycine and N-acetylcysteine (NAC), a stable sou…
Longevity
Alpha-Ketoglutarate (AKG / Calcium AKG)
Alpha-ketoglutarate (AKG) is a compound central to the body's energy-producing Krebs cycle…

Explore Other Ingredients

Antioxidant
Curcumin/Turmeric
Curcumin, the main active compound in turmeric (Curcuma longa), is usually taken as a stan…
Cardiovascular
Omega-3 Fatty Acids
Omega-3 fatty acids are polyunsaturated fats. EPA and DHA come from fish, krill and algae…
Anti-Inflammatory
Bromelain
Bromelain is a group of protein-digesting enzymes from the pineapple stem. Its most consis…

Related articles from our blog

📝 Article
Fisetin and Senolytics for Longevity: What the Human Data Shows
Senolytics are one of the most genuinely exciting ideas in aging research. The pitch is elegant: as we age, we accumulat…
August 10, 2026
📝 Article
Fisetin: The Senolytic Flavonoid, and What the Research Actually Shows
Fisetin is the strawberry compound that the longevity world adopted as a "senolytic," a supplement that supposedly clear…
June 29, 2026
📝 Article
🧬 The Longevity Blueprint: Supplements That May Help You Live Better, Longer
We all want to live a long life—but not just longer . We want more years with energy, sharp thinking, and physical vital…
June 06, 2025

Frequently asked questions about Fisetin

What is fisetin used for?

Fisetin is a flavonoid found in fruits such as strawberries and apples. Supplements are mainly marketed for healthy aging because fisetin acted as a senolytic, clearing senescent cells, in laboratory and mouse studies. This has not yet been shown in people.

What is fisetin's role in longevity research?

In mice, fisetin lowered markers of senescent cells and extended lifespan when started late in life. A placebo-controlled Mayo Clinic trial in older adults is registered but has not posted results, so its effect on aging in people is unknown.

How much fisetin should I take?

No human dose has been shown to slow aging. Two trials in men with obesity used 200 mg/day for 12 weeks. Some research protocols use 20 mg per kg of body weight on 2 consecutive days, a regimen based on mouse studies whose results in older adults are not yet posted. Follow the product label and ask a doctor.

Is fisetin safe?

Fisetin is part of a normal diet in small amounts. Supplement trials so far have been small and short, so long-term and high-dose safety is not known. Check with a doctor first if you take medicines or have a health condition.

What is Fisetin?

Fisetin is a flavonoid found in small amounts in fruits and vegetables such as apples, persimmons, grapes, onions and cucumbers, with higher levels in strawberries. It is studied in longevity research as a possible senolytic, a compound that removes senescent cells, which stop dividing and build up with age.

Does Fisetin interact with any medications?

Possible interactions include: Interactions with fisetin supplements have not been studied in people. People taking prescription medicines, including blood thinners, diabetes medicines or cancer treatment, should ask a doctor or pharmacist before use, especially at high doses. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Fisetin?

NutraSmarts rates the evidence for Fisetin as Preliminary (1 out of 5). It is backed by 2 study summaries and 6 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(6 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. doi: 10.1016/j.ebiom.2018.09.015.PubMedUsed to support: Laboratory and mouse study: of 10 flavonoids screened against senescent mouse and human cells, fisetin was the most active. In progeroid and aged mice it reduced senescence markers in several tissues, and given to normal mice late in life it reduced age-related pathology and extended median and maximum lifespan. It also reduced senescence in a subset of cells in human fat tissue samples. No human trial.
  2. Alipour M, Saeidi A, Hejazi K, Laher I, Zouhal H. 12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial. J Int Soc Sports Nutr. 2026;23(1):2679718. doi: 10.1080/15502783.2026.2679718.PubMedUsed to support: 12-week randomized trial in 44 men with obesity, with placebo, fisetin 200 mg/day, exercise with placebo, and exercise with fisetin groups. IL-6 fell with fisetin alone and with exercise; TNF-alpha, fasting glucose, insulin and HOMA-IR fell in all active groups, most with the combination. Aging and senescent cells were not measured.
  3. Alipour M, Saeidi A, Hejazi K, Supriya R, Zouhal H. The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial. Nutrients. 2026;18(3). doi: 10.3390/nu18030433.PubMedUsed to support: 12-week double-blind randomized trial in 60 sedentary men with obesity using the same four groups. All active groups lost more weight than placebo; the exercise plus fisetin group had the largest falls in asprosin and MCP-1 and the clearest lipid improvements.
  4. Tavenier J, Nehlin JO, Houlind MB, Rasmussen LJ, Tchkonia T, Kirkland JL, Andersen O, Rasmussen LJH. Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases. Mech Ageing Dev. 2024;222:111995. doi: 10.1016/j.mad.2024.111995.PubMedUsed to support: Review of fisetin as a senotherapeutic, covering laboratory, animal and early phase I/II human studies. The authors concluded that safety, pharmacokinetics, dosing and efficacy in people still need to be established.
  5. Deledda A, Giordano E, Velluzzi F, Flore G, Franceschelli S, Speranza L, Ripari P. Mitochondrial Aging and Senolytic Natural Products with Protective Potential. Int J Mol Sci. 2022;23(24). doi: 10.3390/ijms232416219.PubMedUsed to support: Review of laboratory and animal research on natural senolytics, including fisetin, and mitochondrial aging. It is not a human trial.
  6. Mayo Clinic. Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults (AFFIRM-LITE) ClinicalTrials.gov. 2018;NCT03675724..SourceUsed to support: Trial registry record, not PubMed-indexed. Placebo-controlled trial of fisetin 20 mg/kg/day on 2 consecutive days in older adults, with blood inflammation markers as the main outcome. Started November 2018, listed as enrolling by invitation with estimated completion in November 2027, and no results posted.