Home Ingredients FenuKale™ Nu (Blue Fenugreek & Kale Extract — Mibelle)
Hair, Skin & Nails

FenuKale™ Nu (Blue Fenugreek & Kale Extract — Mibelle)

Trigonella caerulea / Brassica oleracea
Evidence Level
Limited
1 Clinical Trial
2 Documented Benefits
2/5 Evidence Score

FenuKale™ Nu is an oral extract of blue fenugreek (Trigonella caerulea) and kale (Brassica oleracea var. acephala) leaves from Mibelle Biochemistry in Switzerland, standardized to at least 12 mg/g flavonoid glycosides and spray-dried on gum arabic. In a 56-day randomized, double-blind, placebo-controlled trial funded by Mibelle, 59 women aged 30 to 55 in Mumbai, India, a city with high air pollution, took 350 mg a day. Water loss through the skin fell more and skin moisture rose compared with placebo, while wrinkles, sagging, elasticity, blood inflammation markers and a blood oxidative stress marker did not improve significantly. In lab tests the extract reduced protein oxidation in skin cells exposed to fine dust and UVA light. This is one maker-funded trial, so the results need independent confirmation.

Studied Dose 350 mg per day for 56 days in the branded skin trial, taken as one 175 mg capsule before breakfast and one after lunch.
Active Compound Leaf extract of blue fenugreek (Trigonella caerulea) and kale (Brassica oleracea var. acephala), standardized to at least 12 mg/g flavonoid glycosides and spray-dried with gum arabic. Made by Mibelle Biochemistry.

Benefits

Skin moisture and barrier function

In a placebo-controlled trial in 59 women living in Mumbai, 350 mg a day for 56 days reduced water loss through the skin and raised skin moisture compared with placebo. Wrinkles, sagging and elasticity did not change significantly. This one trial was funded by the maker.

Supported by Trial 1

Skin cell protection from pollution and UV in lab tests

In human skin cells exposed to fine dust plus UVA light or to hydrogen peroxide, the extract reduced protein oxidation in vitro. In the human trial, a blood oxidative stress marker did not change, so this effect has not been shown in people.

Supported by Trial 1

Mechanism of action

1

Antioxidant flavonoids

Blue fenugreek leaves contain glycosylated flavonoids built on apigenin, luteolin and kaempferol, which the developers propose help skin cells cope with oxidative stress from airborne particles.

2

Reduced protein oxidation in skin cells

In lab tests, the extract lowered protein carbonylation, a marker of oxidative damage, in skin fibroblasts stressed with fine dust and UVA light.

Clinical trials

1
Blue Fenugreek Kale Extract and Skin Barrier (RCT)
PubMed

Randomized, double-blind, placebo-controlled trial of 350 mg/day for 56 days, funded by Mibelle (NCT04544982). (Kappler et al. 2022, Clin Cosmet Investig Dermatol)

59 women aged 30 to 55 with visible signs of skin aging, living in Mumbai, India.

By day 56, transepidermal water loss fell more with the extract than placebo (-5.86 vs -2.32 g/m2/h, p=0.022; not significant at day 28), and forehead skin moisture rose 2.24 percent versus a 2.15 percent fall with placebo (p=0.036). The extract group started the trial with significantly higher water loss than the placebo group. Wrinkle severity, sagging, elasticity, inflammatory markers and blood malondialdehyde did not change significantly. No adverse events were reported.

Side effects and drug interactions

Common Potential side effects

No adverse events were reported in the 56-day trial.
Mild digestive upset is possible.
Avoid if allergic to fenugreek, other legumes or kale.
Pregnancy and breastfeeding: no safety data for this extract, so avoid concentrated use.

Important Drug interactions

Diabetes medicines and blood thinners: fenugreek seed products are often flagged for these, and this leaf extract has not been tested with them; ask a doctor first.
Thyroid conditions: very high kale intake is a theoretical concern for thyroid function; check with a doctor if unsure.

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Frequently asked questions about FenuKale™ Nu (Blue Fenugreek & Kale Extract — Mibelle)

What does FenuKale Nu do?

It is an oral blue fenugreek and kale leaf extract from Mibelle aimed at skin under pollution stress. In one placebo-controlled trial in Mumbai, 350 mg a day for 56 days reduced water loss through the skin and raised skin moisture, without changing wrinkles or elasticity.

Is FenuKale Nu well evidenced?

It has one maker-funded human trial plus lab data, so the evidence is limited until an independent trial confirms the results.

What is FenuKale Nu?

FenuKale™ Nu is an oral extract of blue fenugreek (Trigonella caerulea) and kale (Brassica oleracea var. acephala) leaves from Mibelle Biochemistry in Switzerland, standardized to at least 12 mg/g flavonoid glycosides and spray-dried on gum arabic.

What is FenuKale Nu used for?

FenuKale Nu is researched primarily for Hair, Skin & Nails. In a placebo-controlled trial in 59 women living in Mumbai, 350 mg a day for 56 days reduced water loss through the skin and raised skin moisture compared with placebo. Wrinkles, sagging and elasticity did not change significantly.

What is the recommended dosage of FenuKale Nu?

The clinically studied dose is 350 mg per day for 56 days in the branded skin trial, taken as one 175 mg capsule before breakfast and one after lunch. Always follow the product label and check with a healthcare provider for personal advice.

Is FenuKale Nu safe, and does it have side effects?

Side effects and cautions reported for FenuKale Nu include: No adverse events were reported in the 56-day trial. Mild digestive upset is possible. It may also interact with some medications. FenuKale Nu is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does FenuKale Nu interact with any medications?

Possible interactions include: Diabetes medicines and blood thinners: fenugreek seed products are often flagged for these, and this leaf extract has not been tested with them; ask a doctor first. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for FenuKale Nu?

NutraSmarts rates the evidence for FenuKale Nu as Limited (2 out of 5). It is backed by 1 study summary and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Kappler K, Grothe T, Srivastava S, Jagtap M. Evaluation of the Efficacy and Safety of Blue Fenugreek Kale Extract on Skin Health and Aging: In-vitro and Clinical Evidences. Clin Cosmet Investig Dermatol. 2022;15:2051-2064. doi: 10.2147/CCID.S368576.PubMedUsed to support: The branded FenuKale Nu study, funded by Mibelle. Randomized, double-blind, placebo-controlled trial in 59 women aged 30 to 55 in Mumbai: 350 mg/day for 56 days reduced transepidermal water loss and increased skin moisture versus placebo, with no significant change in wrinkles, sagging, elasticity, inflammatory markers or blood malondialdehyde. Lab tests showed less protein oxidation in stressed skin cells.