Home Ingredients Eternalyoung® (Four-Botanical Skin Blend — Monteloeder)
Hair, Skin & Nails

Eternalyoung® (Four-Botanical Skin Blend — Monteloeder)

Evidence Level
Limited
0 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

Eternalyoung® is a botanical nutricosmetic from Monteloeder blending pomegranate, sweet orange, desert ginseng (Cistanche), and gotu kola, taken as a 225 mg capsule once a day. Two 12-week randomized, double-blind, placebo-controlled trials in women (60 and 71 participants) reported improvements in wrinkle depth or volume, skin elasticity and skin pigmentation. Both were co-authored by the ingredient supplier and published in journals not indexed in MEDLINE, there is no independent replication, and the antioxidant and cellular-aging mechanisms have so far only been shown in cultured skin cells.

Studied Dose 225 mg per day as a single capsule, taken about 30 minutes before or after a meal. This is the dose used in both 12-week human trials.
Active Compound Blend of pomegranate (Punica granatum), sweet orange (Citrus sinensis), Cistanche deserticola, and gotu kola (Centella asiatica).

Benefits

Skin appearance

Two 12-week randomized, double-blind, placebo-controlled trials have measured visible skin change. In 60 women with signs of sun and chronological ageing, crow's-feet wrinkle depth improved significantly compared with placebo from week 4. In 71 women aged 30 to 66, forehead wrinkle volume fell 23.3% from baseline by week 12 while the placebo group rose 13.6%, a significant difference between groups at week 12, and wrinkle count fell 24% (between-group p = 0.06). Skin gloss rose 20.2% from baseline with placebo essentially unchanged, though the between-group difference for gloss reached significance only in the subgroup who started with duller or more wrinkled skin. Read these with care: both trials were co-authored by the ingredient supplier; in the second trial the wrinkle-volume analysis included only 28 of 36 supplement and 30 of 35 placebo participants, and the gloss analysis only 24 of 36 and 30 of 35; and on both endpoints the supplement group started further from ideal than placebo (wrinkle volume 3.87 versus 2.65 mm3, gloss 6.23 versus 6.88 GU), which leaves more room for a percentage change.

Skin elasticity and hydration

Skin elasticity, firmness and ultrasound-measured skin thickness improved significantly compared with placebo in the 60-woman trial, which also found gains in moisturisation and barrier function. Hydration is less consistent: the later 71-woman trial found no difference from placebo in overall forehead hydration or transepidermal water loss. Among the minority who started dry (corneometer under 40 a.u.), hydration beat placebo only at week 2, and by week 12 the placebo group had improved almost as much (22% versus 30%). Among those who started with a weakened barrier (transepidermal water loss above 15), both groups improved and the two never differed significantly from each other at any visit. Collagen itself has never been measured in people taking this blend.

Antioxidant and healthy-aging support

In cultured human skin fibroblasts the blend lowered reactive oxygen species after a hydrogen-peroxide challenge and prevented the build-up of glycated proteins after UV exposure. These are cell-culture findings only. No antioxidant status marker and no advanced glycation end-product measurement has been taken in the blood or skin of anyone taking the supplement, and no measure of general ageing or lifespan has been studied in people.

Mechanism of action

1

Antioxidant and anti-glycation action

In cultured human dermal fibroblasts, the polyphenol-rich extracts lowered intracellular reactive oxygen species after an oxidative challenge and prevented the accumulation of advanced glycation end-products after UV irradiation. Advanced glycation end-products stiffen collagen in ageing skin, but whether the capsule changes them in living human skin has not been tested.

2

Cellular-aging support

In the same fibroblast experiments the blend slowed telomere shortening in both dividing and oxidatively stressed cells, briefly raised telomerase activity at 24 hours, and restored viability in cells damaged by hydrogen peroxide. Collagen synthesis was not among the measurements taken, and none of these cellular changes has been demonstrated in human skin or in blood.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild digestive upset is occasionally reported.
Safety data cover 131 women randomized across two 12-week trials, with no serious adverse events reported; there is no information on use beyond 12 weeks, in men, or during pregnancy or breastfeeding.

Important Drug interactions

No major drug interactions are established for this blend.
Tell your doctor about all supplements if you take medication.
Use caution if pregnant or breastfeeding.

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Frequently asked questions about Eternalyoung® (Four-Botanical Skin Blend — Monteloeder)

What is Eternalyoung?

Eternalyoung® is a botanical nutricosmetic from Monteloeder blending pomegranate, sweet orange, desert ginseng (Cistanche), and gotu kola, taken as a 225 mg capsule once a day.

What is Eternalyoung used for?

Eternalyoung is researched primarily for Hair, Skin & Nails. Two 12-week randomized, double-blind, placebo-controlled trials have measured visible skin change. In 60 women with signs of sun and chronological ageing, crow's-feet wrinkle depth improved significantly compared with placebo from week 4.

What is the recommended dosage of Eternalyoung?

The clinically studied dose is 225 mg per day as a single capsule, taken about 30 minutes before or after a meal. This is the dose used in both 12-week human trials. Always follow the product label and check with a healthcare provider for personal advice.

Is Eternalyoung safe, and does it have side effects?

For most healthy adults, Eternalyoung is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild digestive upset is occasionally reported. It may also interact with some medications. Eternalyoung is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Eternalyoung interact with any medications?

Possible interactions include: No major drug interactions are established for this blend. Tell your doctor about all supplements if you take medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Eternalyoung?

NutraSmarts rates the evidence for Eternalyoung as Limited (2 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Quiles J, Cabrera M, Jones J, Tsapekos M, Caturla N In Vitro Determination of the Skin Anti-Aging Potential of Four-Component Plant-Based Ingredient Molecules. 2022;27(22):8101. doi:10.3390/molecules27228101.PubMedUsed to support: Cell-culture study of the four-botanical blend (pomegranate, sweet orange, Cistanche and Centella asiatica) in normal human dermal fibroblasts. The blend reversed a hydrogen-peroxide-induced fall in cell viability, lowered intracellular reactive oxygen species, slowed the rate of telomere shortening in both stressed and unstressed dividing cells, left fewer very short telomeres under oxidative stress, transiently raised telomerase activity at 24 hours, and prevented the accumulation of glycated species after UV irradiation. No animals or people were treated and collagen was not measured, so these findings describe what the extracts do to cells in a dish rather than what the capsule does to skin. Three of the five authors work in Monteloeder's research and development department.
  2. Nobile V, Schiano I, Germani L, Cestone E, Navarro P, Jones J, Caturla N. Skin Anti-Aging Efficacy of a Four-Botanical Blend Dietary Ingredient: A Randomized, Double Blind, Clinical Study. Cosmetics. 2023;10(1):16. doi: 10.3390/cosmetics10010016.SourceUsed to support: Twelve-week randomized, double-blind, placebo-controlled trial in 60 Caucasian women with visible signs of chronological and sun-induced skin ageing taking 225 mg per day of the four-botanical blend. Compared with placebo, the supplement group showed significant improvements from week 4 in wrinkle depth, skin elasticity and firmness, ultrasound-measured skin thickness, moisturisation, transepidermal water loss and dark-spot pigmentation, with no side effects reported. The trial was run by an independent Italian contract research organisation, but three of the seven authors work in the ingredient supplier's research department, and the journal is not indexed in MEDLINE.
  3. Navarro P, Garcia A, Jones J, Caturla N. Efficacy of a botanical-based nutricosmetic ingredient on skin aging-related markers in adult women. Journal of Dermatology & Cosmetology. 2025;9(4):119-125. doi: 10.15406/jdc.2025.09.00305.SourceUsed to support: Twelve-week randomized, double-blind, placebo-controlled trial in 71 women aged 30 to 66 taking a 225 mg capsule of the blend or matched placebo daily. Forehead wrinkle volume fell 23.3% from baseline by week 12 while the placebo group increased 13.6%, a significant difference between groups at week 12 (28 supplement and 30 placebo participants were included in this analysis, and the supplement group started with larger wrinkles, 3.87 versus 2.65 mm3). Wrinkle count fell 24%, but the between-group comparison did not reach significance (p = 0.06). Melanin index fell 13.9% versus 7.3% on placebo, with significant between-group differences at weeks 2, 8 and 12, though the supplement group also began with a higher melanin index (209 versus 179 a.u.). Forehead gloss rose 20.2% from baseline with placebo unchanged, but only 24 of 36 supplement and 30 of 35 placebo participants were included in that analysis, and the between-group difference reached significance only in the subgroup with duller or more wrinkled skin at baseline (p = 0.021). Overall hydration and transepidermal water loss showed no difference from placebo. One participant reported persistent mild flatulence and no serious adverse events occurred. All four authors work in the ingredient supplier's research and development department, and the journal is not indexed in MEDLINE.