Home Ingredients Enovita® (Grape Seed Procyanidin Phytosome)
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Enovita® (Grape Seed Procyanidin Phytosome)

Vitis vinifera
Evidence Level
Moderate
2 Clinical Trials
5 Documented Benefits
3/5 Evidence Score

Enovita® (Indena) is a grape seed extract standardized to roughly 95% proanthocyanidins (procyanidins) and delivered as a Phytosome® — the polyphenols complexed with phospholipids to improve absorption. It is studied for endothelial function, healthy blood pressure, and antioxidant support. Enovita® sits alongside several related entries on the site, including generic grape seed extract, Leucoselect® Phytosome, and MegaNatural-BP®, all of which share the grape-polyphenol mechanism. Evidence for grape seed procyanidins on blood pressure is reasonably supportive across pooled trials, with the phospholipid delivery intended to enhance bioavailability of the active polyphenols.

Studied Dose Grape seed procyanidin trials commonly used ~150–300 mg/day; the Enovita® registry study evaluated 150 mg and 300 mg/day.
Active Compound Grape seed proanthocyanidins/procyanidins (~95%) complexed with phospholipids (Phytosome®) — Enovita® by Indena, for enhanced polyphenol absorption.

Benefits

Healthy Blood Pressure Support

Grape seed procyanidins may help support blood pressure that is in the high-normal or mildly elevated range. In the Enovita® registry study, a higher dose was associated with meaningful, dose-dependent improvements in blood pressure alongside diet and lifestyle measures.

Supported by Trial 1, Trial 2

Endothelial Function and Microcirculation

Grape polyphenols support nitric-oxide-mediated vasodilation and healthy endothelial function. Enovita® has been evaluated with microcirculation measures, supporting its positioning for vascular and circulatory health.

Supported by Trial 1, Trial 2

Enhanced Polyphenol Absorption

The Phytosome® delivery complexes procyanidins with phospholipids to improve their absorption, addressing the generally low bioavailability of dietary proanthocyanidins. This is the core rationale for the branded form versus plain extract.

Supported by Trial 1, Trial 2

Antioxidant Defense

Grape seed procyanidins are potent antioxidants that help neutralize free radicals and limit oxidation of LDL particles. This antioxidant action complements the vascular benefits and supports overall cardiovascular wellness.

Supported by Trial 1, Trial 2

Cardiovascular Wellness Adjunct

As part of a heart-healthy lifestyle, standardized grape seed procyanidins may support markers of cardiovascular health. Pooled trial data favor a modest beneficial effect on blood pressure across populations.

Supported by Trial 2, Trial 1

Mechanism of action

1

Nitric Oxide and Endothelial Signaling

Procyanidins enhance endothelial nitric oxide synthase activity and nitric-oxide availability, promoting vasodilation and supporting healthy endothelial function and microcirculation.

2

Antioxidant and LDL Protection

Grape seed proanthocyanidins scavenge reactive oxygen species and inhibit LDL oxidation, reducing oxidative stress that contributes to endothelial dysfunction and arterial aging.

3

Phospholipid (Phytosome) Delivery

Complexing procyanidins with phospholipids creates a more lipophilic carrier that improves intestinal absorption and plasma exposure of the polyphenols relative to non-complexed extract.

4

Mild ACE and Vascular Tone Modulation

Grape polyphenols have been reported to modestly modulate angiotensin-converting enzyme activity and vascular smooth-muscle tone, contributing to their blood-pressure effects.

Clinical trials

1
Enovita® in Pre- and Mild Hypertension

Controlled registry study of standardized grape seed procyanidins (Enovita®) at 150 mg/day and 300 mg/day with diet and lifestyle modification in 119 pre- and mildly hypertensive adults over 4 months.

119 healthy pre- and mildly hypertensive adults.

A dose-dependent improvement in blood pressure, heart rate, microcirculation, and oxidative status was observed, with blood pressure normalizing in most of the higher-dose group. Supports the blood-pressure and microcirculation benefits for the branded form.

2
Grape Seed Extract and Blood Pressure (Pooled)

Meta-analysis of 16 randomized controlled trials evaluating grape seed extract effects on blood pressure.

Pooled across 16 randomized trials (about 810 participants).

Grape seed extract was associated with beneficial reductions in systolic and diastolic blood pressure across trials. This pooled evidence supports the cardiovascular positioning of standardized grape seed procyanidins like Enovita®.

Side effects and drug interactions

Common Potential side effects

Generally well tolerated.
Mild headache, nausea, or dizziness reported occasionally.
Possible additive blood-pressure lowering; monitor if on antihypertensives.
Theoretical increased bleeding risk at high doses due to antiplatelet polyphenol effects.
Limited specific safety data in pregnancy and lactation.

Important Drug interactions

Antihypertensive drugs — possible additive blood-pressure lowering; monitor.
Anticoagulant or antiplatelet drugs — theoretical additive bleeding risk; use caution.
Drugs metabolized by CYP enzymes — grape polyphenols may modestly affect metabolism; theoretical interaction.
NSAIDs — combined antiplatelet effect could increase bleeding risk; use caution.

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Frequently asked questions about Enovita® (Grape Seed Procyanidin Phytosome)

What is the recommended dosage of Enovita® (Grape Seed Procyanidin Phytosome)?

The clinically studied dose for Enovita® (Grape Seed Procyanidin Phytosome) is Grape seed procyanidin trials commonly used ~150–300 mg/day; the Enovita® registry study evaluated 150 mg and 300 mg/day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Enovita® (Grape Seed Procyanidin Phytosome) used for?

Enovita® (Grape Seed Procyanidin Phytosome) is studied for healthy blood pressure support, endothelial function and microcirculation, enhanced polyphenol absorption. Grape seed procyanidins may help support blood pressure that is in the high-normal or mildly elevated range.

Are there side effects from taking Enovita® (Grape Seed Procyanidin Phytosome)?

Reported potential side effects may include: Generally well tolerated. Mild headache, nausea, or dizziness reported occasionally. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Enovita® (Grape Seed Procyanidin Phytosome) interact with medications?

Known drug interactions may include: Antihypertensive drugs — possible additive blood-pressure lowering; monitor. Anticoagulant or antiplatelet drugs — theoretical additive bleeding risk; use caution. Consult a pharmacist or healthcare provider if you take prescription medications.

Is Enovita® (Grape Seed Procyanidin Phytosome) good for cardiovascular?

Yes, Enovita® (Grape Seed Procyanidin Phytosome) is researched for Cardiovascular support. Grape seed procyanidins may help support blood pressure that is in the high-normal or mildly elevated range. In the Enovita® registry study, a higher dose was associated with meaningful, dose-dependent improvements in blood pressure alongside diet and lifestyle measures.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Belcaro G, Ledda A, Hu S, Cesarone MR, Feragalli B, Dugall M. Grape seed procyanidins in pre- and mild hypertension: a registry study. Evid Based Complement Alternat Med. 2013;2013:313142. doi: 10.1155/2013/313142.PubMedUsed to support: Backs the Enovita® blood-pressure and microcirculation benefits: dose-dependent BP and microcirculation improvements with 150-300 mg/day of the branded extract.
  2. Zhang H, Liu S, Li L, Liu S, Liu S, Mi J, Tian G. The impact of grape seed extract treatment on blood pressure changes: a meta-analysis of 16 randomized controlled trials. Medicine (Baltimore). 2016;95(33):e4247. doi: 10.1097/MD.0000000000004247.PubMedUsed to support: Supports the generic-class blood-pressure benefit: pooled grape seed extract trials showed beneficial reductions in systolic and diastolic blood pressure.