Home Ingredients EnoSTIM™ (Apple, Grape and Saffron Blend — Nexira)
Men's HealthLibido Support

EnoSTIM™ (Apple, Grape and Saffron Blend — Nexira)

Evidence Level
Preliminary
1 Clinical Trial
3 Documented Benefits
1/5 Evidence Score

EnoSTIM™ is a blend of grape and apple polyphenols with saffron, made by Nexira in France and taken at 600 mg a day. The only published study of the finished blend was funded by Nexira and had no placebo group: 103 men aged 45 to 65 who reported softer erections started, 94 finished, and over 28 days their average Erection Hardness Score rose from 2.7 to 3.3. Because every man took the product and knew it, that change cannot be separated from expectation or natural variation. Saffron alone has been tested in men with mixed results: a small placebo-controlled trial in men with antidepressant-related sexual difficulty was positive, while a larger trial in men with erectile difficulty found no benefit. A grape and apple polyphenol preparation from Nexira has been tested in people for exercise endurance, not sexual function. No placebo-controlled trial of EnoSTIM™ itself has been published.

Studied Dose 600 mg/day for 28 days in the one published study of the blend, which had no placebo group.
Active Compound Grape polyphenols, apple polyphenols and saffron extract in a proprietary ratio. The amount of each component in a 600 mg dose is not given in the published study.

Benefits

Male erection quality in an uncontrolled 28-day study

In a Nexira-funded observational study, 94 men aged 45 to 65 who took 600 mg/day for 28 days reported an average Erection Hardness Score rising from 2.7 to 3.3 and IIEF-5 scores from 15.6 to 17.7. There was no placebo group, so expectation alone could explain part or all of this change.

Supported by Trial 1

Saffron and sexual function in men

Saffron on its own improved erectile function scores over placebo in a 4-week trial of 36 men with antidepressant-related sexual difficulty, but a 12-week trial in 346 men with erectile difficulty found no benefit. The saffron dose in EnoSTIM™ is not disclosed, and the blend itself has not been compared with placebo.

Supported by Trial 1

Grape and apple polyphenols and exercise endurance

A grape and apple polyphenol preparation from the same maker increased time to exhaustion in a high-intensity test by 9.7% over placebo in 48 active men. This was a single-occasion test of endurance, not of blood flow or sexual function, and it was funded by the maker.

Supported by Trial 1

Mechanism of action

1

Proposed nitric oxide and blood flow route

Erection depends on blood flow into the penis, which nitric oxide helps control. The maker proposes that the polyphenols support nitric oxide production, but blood flow and nitric oxide have not been measured in any published human study of EnoSTIM™.

2

Polyphenols as antioxidants

Grape and apple polyphenols have antioxidant activity in the laboratory. Whether this changes anything relevant to sexual function in people taking the blend has not been tested.

3

Saffron

Saffron has been studied in human trials of sexual function with mixed results, and how it might act is not established. Effects of saffron alone cannot be assumed for this blend, whose saffron content is not disclosed.

Clinical trials

1
EnoSTIM™ in men aged 45 to 65: observational study without a placebo group
PubMed

28-day open study in which every participant took EnoSTIM™ 600 mg/day, with outcomes reported through a smartphone app. Funded by Nexira; one author works for Nexira. Published in a journal not indexed in PubMed. (Allaert et al. 2021, Arch Biomed Eng Biotechnol)

103 men aged 45 to 65 (mean 53.4) with an Erection Hardness Score of 2 to 3 in the previous month; 94 completed.

Average Erection Hardness Score rose from 2.7 to 3.3 and IIEF-5 from 15.6 to 17.7, and the share of erections firm enough for penetration rose from 68.0% to 87.7%; 73.8% of men improved their hardness score. No significant side effects were reported. With no comparison group, these within-group changes cannot be credited to the product.

Side effects and drug interactions

Common Potential side effects

No significant side effects were reported in the 28-day study of the blend, but there are no placebo-controlled or longer-term safety data.
Side effect frequency did not differ from placebo in a small 4-week trial of saffron alone.
Erectile difficulty can have medical causes, so men with ongoing difficulty should see a doctor rather than rely on a supplement.

Important Drug interactions

Interactions with EnoSTIM™ have not been studied.
Men taking nitrates, erectile dysfunction medicines, blood pressure medicines or blood thinners should ask a doctor or pharmacist before use.
Men taking antidepressants should ask their prescriber before using a saffron product.

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Frequently asked questions about EnoSTIM™ (Apple, Grape and Saffron Blend — Nexira)

What is EnoSTIM?

EnoSTIM™ is a blend of grape and apple polyphenols with saffron, made by Nexira in France and taken at 600 mg a day. The only published study of the finished blend was funded by Nexira and had no placebo group: 103 men aged 45 to 65 who reported softer erections started, 94 finished, and over 28 days their average Erec…

What is EnoSTIM used for?

EnoSTIM is researched primarily for Men's Health and Libido Support. In a Nexira-funded observational study, 94 men aged 45 to 65 who took 600 mg/day for 28 days reported an average Erection Hardness Score rising from 2.7 to 3.3 and IIEF-5 scores from 15.6 to 17.7.

What is the recommended dosage of EnoSTIM?

The clinically studied dose is 600 mg/day for 28 days in the one published study of the blend, which had no placebo group. Always follow the product label and check with a healthcare provider for personal advice.

Is EnoSTIM safe, and does it have side effects?

Side effects and cautions reported for EnoSTIM include: No significant side effects were reported in the 28-day study of the blend, but there are no placebo-controlled or longer-term safety data. Side effect frequency did not differ from placebo in a small 4-week trial of saffron alone. It may also interact with some medications. EnoSTIM is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does EnoSTIM interact with any medications?

Possible interactions include: Interactions with EnoSTIM™ have not been studied. Men taking nitrates, erectile dysfunction medicines, blood pressure medicines or blood thinners should ask a doctor or pharmacist before use. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for EnoSTIM?

NutraSmarts rates the evidence for EnoSTIM as Preliminary (1 out of 5). It is backed by 1 study summary and 7 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(7 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Allaert F, Guillemet D, Schueller R, Herpin F. Evaluation of the Effectiveness of Polyphenols from Grape and Apple Combined with Saffron on Erectile Function: An Observational Study Archives in Biomedical Engineering & Biotechnology. 2021;5(4). doi: 10.33552/ABEB.2021.05.000619.SourceUsed to support: Not PubMed-indexed. Observational study without a placebo group in which 103 men aged 45 to 65 took EnoSTIM™ 600 mg/day for 28 days and 94 completed. Average Erection Hardness Score rose from 2.7 to 3.3 and IIEF-5 from 15.6 to 17.7. Funded by Nexira; one author is Nexira's director of scientific development.
  2. Modabbernia A, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh S. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl). 2012;223(4):381-8. doi: 10.1007/s00213-012-2729-6.PubMedUsed to support: Randomized double-blind trial in 36 men with depression stabilized on fluoxetine who reported sexual difficulty; 30 completed. Saffron 15 mg twice daily for 4 weeks improved erectile function, intercourse satisfaction and total IIEF scores more than placebo, but not desire, orgasm or overall satisfaction. Saffron was given alone.
  3. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impot Res. 2010;22(4):240-50. doi: 10.1038/ijir.2010.10.PubMedUsed to support: Open-label randomized crossover trial in 346 men with erectile difficulty comparing 12 weeks of on-demand sildenafil with 12 weeks of saffron 30 mg twice daily. Saffron produced no significant improvement in any IIEF domain or satisfaction score, and the authors concluded the results do not support a benefit.
  4. Ranjbar H, Ashrafizaveh A. Effects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis. Avicenna J Phytomed. 2019;9(5):419-427..PubMedUsed to support: Meta-analysis of 5 studies with 173 men and women combined. Saffron improved sexual function scores overall (standardized mean difference 0.811, 95% CI 0.356 to 1.265), with heterogeneity between studies (I2 about 60%). The evidence base is small, and saffron was given alone.
  5. Borrelli F, Colalto C, Delfino DV, Iriti M, Izzo AA. Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis. Drugs. 2018;78(6):643-673. doi: 10.1007/s40265-018-0897-3.PubMedUsed to support: Systematic review of 24 randomized trials (2,080 men with erectile difficulty) of herbal supplements. Ginseng improved erectile function over placebo, while saffron (3 trials, 397 men) gave mixed results. Only 7 trials had a mainly low risk of bias, and the authors called for more research before herbal products can be recommended.
  6. Deley G, Guillemet D, Allaert FA, Babault N. An Acute Dose of Specific Grape and Apple Polyphenols Improves Endurance Performance: A Randomized, Crossover, Double-Blind versus Placebo Controlled Study. Nutrients. 2017;9(8). doi: 10.3390/nu9080917.PubMedUsed to support: Randomized double-blind crossover trial in 48 active men: 500 mg of a grape and apple polyphenol preparation lengthened time to exhaustion in an endurance test by 9.7% over placebo. Sexual function and blood flow were not measured. One author is employed by the maker.
  7. Odai T, Terauchi M, Kato K, Hirose A, Miyasaka N. Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2019;11(12). doi: 10.3390/nu11122844.PubMedUsed to support: Randomized double-blind trial in 30 adults aged 40 to 64 with high-normal blood pressure (6 men, 24 women) given grape seed extract 200 or 400 mg/day or placebo for 12 weeks. Flow-mediated dilation did not change; systolic blood pressure fell by 13 mmHg in the 400 mg group. No sexual function measure was taken, and grape seed extract was given alone.