Home Ingredients Cran-Gyn PRO® (Cranberry for Urinary and Feminine Health)
Kidney/Urinary TractWomen's Health

Cran-Gyn PRO® (Cranberry for Urinary and Feminine Health)

Vaccinium macrocarpon
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Cran-Gyn pro® is a cranberry-based ingredient developed for urinary tract health, supplying cranberry proanthocyanidins. It supports urinary tract health through cranberry's bacterial anti-adhesion action.

Studied Dose Commonly around 500 mg of cranberry concentrate per day.
Active Compound Cranberry (Vaccinium macrocarpon) concentrate providing proanthocyanidins (PACs).

Benefits

Urinary tract health

Cranberry is widely studied for supporting urinary tract health and is commonly used to help maintain a healthy urinary tract.

Supported by Trial 1

Anti-adhesion action

Cranberry proanthocyanidins help stop certain bacteria from sticking to the bladder wall, the leading proposed mechanism.

Supported by Trial 1

Antioxidant support

Cranberry polyphenols provide antioxidant support beyond the urinary tract.

Supported by Trial 1

Mechanism of action

1

Type-A proanthocyanidins

Cranberry's distinctive type-A PACs interfere with the fimbriae E. coli use to adhere to the urinary lining, helping bacteria be flushed out.

2

Polyphenol antioxidants

Cranberry's broad polyphenols add antioxidant activity supporting overall health.

Clinical trials

1
Cranberry and Urinary Tract Health — Review
PubMed

Review of non-antibiotic interventions, including cranberry, to prevent recurrent urinary tract infections. (Santer et al. 2026, British Journal of General Practice)

Adults prone to recurrent urinary symptoms; note this is a general cranberry review, not a trial of the Cran-Gyn PRO branded form specifically.

The review supports cranberry as an option for supporting urinary tract health.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild digestive upset at high doses.
Very high intake may raise kidney-stone risk in susceptible people.

Important Drug interactions

Warfarin — cranberry may interact; monitor INR if combined.
Not a substitute for antibiotics during an active infection.
Tell your doctor about a history of kidney stones.

More Kidney/Urinary Tract Ingredients

Kidney/Urinary Tract
Exocyan™ (Cranberry Extract for UTI)
Exocyan™ is Nexira's (France) standardized cranberry extract (Vaccinium macrocarpon) — dis…
Kidney/Urinary Tract
Pacran® (Whole Cranberry Fruit Powder — Givaudan/Naturex)
Pacran is a branded whole-fruit cranberry powder from Givaudan (formerly Naturex), deliver…
Kidney/Urinary Tract
Flowens™ (Cranberry for Men's & Women's Urological Health — Givaudan)
Flowens™ is Givaudan's (formerly Naturex) standardized whole-fruit cranberry ingredient (V…
Kidney/Urinary Tract
MannoHealth™ (D-Mannose — Bioenergy Life Science)
MannoHealth™ is Bioenergy Life Science's branded high-purity D-mannose — distinguished as…

Frequently asked questions about Cran-Gyn PRO® (Cranberry for Urinary and Feminine Health)

What is Cran-Gyn PRO?

Cran-Gyn pro® is a cranberry-based ingredient developed for urinary tract health, supplying cranberry proanthocyanidins. It supports urinary tract health through cranberry's bacterial anti-adhesion action.

What is Cran-Gyn PRO used for?

Cran-Gyn PRO is researched primarily for Kidney/Urinary Tract and Women's Health. Cranberry is widely studied for supporting urinary tract health and is commonly used to help maintain a healthy urinary tract.

What is the recommended dosage of Cran-Gyn PRO?

The clinically studied dose is Commonly around 500 mg of cranberry concentrate per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Cran-Gyn PRO safe, and does it have side effects?

For most healthy adults, Cran-Gyn PRO is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild digestive upset at high doses. It may also interact with some medications. Cran-Gyn PRO is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Cran-Gyn PRO interact with any medications?

Possible interactions include: Warfarin — cranberry may interact; monitor INR if combined. Not a substitute for antibiotics during an active infection. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Cran-Gyn PRO?

NutraSmarts rates the evidence for Cran-Gyn PRO as Moderate (3 out of 5). It is backed by 1 clinical trial and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Santer M, Miller S, Fraser S, et al. Non-antibiotic interventions to prevent recurrent urinary tract infections. Br J Gen Pract. 2026;(advance)..PubMedUsed to support: Review supporting urinary-tract benefit of cranberry (the active in this branded cranberry).
  2. Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;11(11):CD001321. doi:10.1002/14651858.CD001321.pub7.PubMedUsed to support: Cochrane systematic review (50+ studies): cranberry products reduce the risk of recurrent UTI in women and in children (moderate-certainty evidence). The strongest evidence base for cranberry (the active in this branded product); not a trial of Cran-Gyn PRO specifically.