Benefits
Bone Health Support
Cissus has documented effects on bone metabolism — supports bone formation markers; relevant to bone density support.
Fracture Healing Adjunct
Long traditional use for fracture healing ('Asthi Sandhani' = bone-uniter); modern animal and limited human research supports.
Joint Health
Reduces inflammatory markers in joint tissue; supports comprehensive joint health.
Exercise Recovery
Some athletes report improved recovery from training; cortisol modulation may contribute.
Cortisol Modulation in Athletes
Some evidence for cortisol-lowering effects relevant to overtraining syndrome.
Glucocorticoid Receptor Effects
Some research suggests anti-glucocorticoid activity — relevant to bone health (glucocorticoids cause bone loss).
Mechanism of action
Anti-Glucocorticoid Activity
Some research suggests Cissus has anti-glucocorticoid effects; relevant to bone health (chronic glucocorticoid exposure causes osteoporosis) and possibly cortisol-related concerns.
Bone Formation Support
Effects on osteoblast function and bone formation markers.
Anti-Inflammatory
Reduces inflammatory markers relevant to joint health.
Antioxidant Activity
Vitamin C and polyphenol content provide antioxidant support.
Clinical trials
Multiple animal studies of Cissus on fracture healing and bone formation.
Animal models.
Documented effects on bone formation and fracture healing rates.
Limited human clinical studies of Cissus for joint and bone applications.
Adults with joint concerns.
Modest improvements in joint comfort markers.
About this ingredient
CISSUS EXTRACT is a STANDARDIZED CISSUS QUADRANGULARIS extract developed by VERDURE SCIENCES. CISSUS BACKGROUND: climbing plant in grape family; native to India and Southeast Asia; traditional Ayurvedic name 'ASTHI SANDHANI' meaning 'bone-uniter'; long traditional use for bone fractures and joint health.
KEY DISTINCTIONS: (1) Verdure standardization; (2) Bone health focus; (3) Athletic recovery applications.
EVIDENCE-BASED USES: (1) Bone health support; (2) Fracture healing adjunct; (3) Joint health; (4) Exercise recovery; (5) Cortisol modulation.
CRITICAL CAUTIONS: (1) HUMAN EVIDENCE LIMITED — most evidence is animal/traditional; modest human research base; (2) DOSE — per Verdure specification; (3) PREGNANCY — limited safety data; AVOID; (4) FOR FRACTURE HEALING — Cissus may be adjunct to standard fracture care (immobilization, calcium, vitamin D, protein adequacy); not replacement for medical management; (5) FOR BONE HEALTH — comprehensive approach: weight-bearing exercise, calcium, vitamin D, protein, possibly bisphosphonates for osteoporosis; supplements adjunct; (6) FOR ATHLETIC RECOVERY — anti-glucocorticoid mechanism may help with overtraining; modest effect; (7) BRAND VERIFICATION — Verdure Cissus is Verdure Sciences product; (8) AYURVEDIC TRADITION — long traditional use validates ongoing research interest.