Benefits
Microcirculation and veins
Centella asiatica is traditionally used to support microcirculation and the tone of veins, relevant to leg heaviness and a feeling of comfort in the legs. The circulation trials people cite for Centella used a purified triterpene fraction sold as a medicine in Europe, not Centevita, and Centevita itself has not been tested for this.
Connective tissue and skin
Centella triterpenes increase collagen production in laboratory tests, which is the basis for the plant's long use in skin care. Be aware that almost all of that work, including the only skin study on Centevita itself, used the extract applied to the skin rather than swallowed, so it does not show what a capsule does.
Traditional use for mental clarity
Centella has a long traditional history of use for mental clarity and a calm, focused state. Modern testing has not borne this out: a 2017 pooled analysis of eleven randomized trials of Centella taken by mouth, alone or inside combination products, found no difference from placebo in any cognitive domain, with only small short term changes in self rated alertness and anger. Centevita has not been tested for cognition at all.
Mechanism of action
Triterpene collagen support
Asiaticoside and madecassoside increase collagen synthesis in cell and tissue experiments, which is the proposed reason for Centella's connective tissue and blood vessel effects. This is laboratory work, not an outcome measured in people taking Centevita.
Antioxidant protection
Centella polyphenols have antioxidant activity in laboratory assays. Antioxidant activity is the main function Indena itself claims for Centevita; effects on blood vessels or the brain in people have not been shown for this extract.
Clinical trials
Phytochemical characterization of the standardized Centella asiatica extract Centevita. (Masi et al. 2022, Fitoterapia)
Laboratory characterization.
The study defined the triterpene and polyphenol profile of the standardized extract, quantifying 24 compounds, confirming that triterpenoids make up roughly 45 percent of the extract by weight, and describing a new saponin the authors named isoterminoloside. It measured no biological or health outcome of any kind: no cells, no animals, no people. There is no published trial of swallowed Centevita. Two of the five authors work for Indena, which sells the extract.