Celery3nB® (Celery Seed Extract Standardized to 3nB)

Apium graveolens

Evidence Level

Limited

0 Clinical Trials

3 Documented Benefits

2/5 Evidence Score

Celery3nB® is a celery (Apium graveolens) seed extract standardized for 3-n-butylphthalide (3nB), the compound that gives celery its aroma and much of its traditional use. The two human trials cited here tested a generic celery seed extract rather than the Celery3nB brand, and both were run in people already diagnosed with high blood pressure. No cited study measured uric acid, gout or any joint outcome, so treat the joint and uric-acid positioning as an untested laboratory idea.

Studied Dose Commonly around 75 to 150 mg of standardized extract per day. This is a typical supplement label range rather than a dose carried over from the published trials, and the trials cited here used a generic celery seed extract rather than Celery3nB, so the dose on a product label may not match what was actually studied.

Active Compound Celery seed extract standardized to 3-n-butylphthalide (3nB).

Blood pressure support

In a randomized, triple-blind, placebo-controlled crossover trial in 52 people already diagnosed with high blood pressure, celery seed extract lowered average systolic pressure from 141.2 to 130.0 mmHg and diastolic from 92.2 to 84.2 mmHg (both statistically significant). Two limits matter: the extract tested was a generic celery seed extract, not the Celery3nB brand, and every participant was a patient under medical care, so this does not show what the extract does for someone whose blood pressure is already in the normal range.

Uric acid: a laboratory idea, not a proven benefit

In laboratory work, 3nB slows xanthine oxidase, the enzyme that makes uric acid. That is where the evidence stops. None of the studies cited on this page measured uric acid levels, gout or any joint or comfort outcome in people, so there is currently no human evidence that celery seed extract does anything for joints or uric acid balance.

Honest evidence note

Human clinical data for standardized celery seed extract are limited and mostly from small studies, so benefits should be viewed with realistic expectations.

3nB vasorelaxation

3-n-butylphthalide is thought to relax blood-vessel walls and affect how the vessels handle calcium. This is the proposed explanation for the blood pressure changes seen in the hypertension trial, but it comes from laboratory and animal work and from a narrative review, not from measurements made in people.

Xanthine oxidase inhibition

In test-tube studies, 3nB inhibits xanthine oxidase, an enzyme involved in making uric acid. This has never been tested in people in any study cited on this page.

Common Potential side effects

Generally well tolerated in the trials run so far, with digestive symptoms the most commonly reported complaint.

Celery is a recognised food allergen and is a labelled allergen in the EU, so anyone with a celery allergy should avoid this extract entirely.

Celery seed can make skin more sensitive to sunlight in some people. It is also traditionally avoided during pregnancy because of its reputation as a uterine stimulant, so do not use it if you are pregnant, breastfeeding or trying to conceive.

Important Drug interactions

Blood pressure medication: celery seed extract measurably lowered blood pressure in the trial, so it can add to the effect of these drugs and push pressure too low. Talk to your doctor before combining them.

Diuretics (water pills): celery has a mild diuretic effect of its own, so tell your doctor if you already take one.

Blood thinners: use caution and tell your doctor before starting this extract.

Frequently asked questions about Celery3nB® (Celery Seed Extract Standardized to 3nB)

What is Celery3nB?

Celery3nB® is a celery (Apium graveolens) seed extract standardized for 3-n-butylphthalide (3nB), the compound that gives celery its aroma and much of its traditional use.

What is Celery3nB used for?

Celery3nB is researched primarily for Cardiovascular. In a randomized, triple-blind, placebo-controlled crossover trial in 52 people already diagnosed with high blood pressure, celery seed extract lowered average systolic pressure from 141.2 to 130.0 mmHg and diastolic from 92.2 to 84.

What is the recommended dosage of Celery3nB?

The clinically studied dose is Commonly around 75 to 150 mg of standardized extract per day. This is a typical supplement label range rather than a dose carried over from the published trials, and the trials cited here used a generic celery seed extract rather than Celery3nB, so the dose on… Always follow the product label and check with a healthcare provider for personal advice.

Is Celery3nB safe, and does it have side effects?

For most healthy adults, Celery3nB is well tolerated at studied doses. Reported effects can include: Generally well tolerated in the trials run so far, with digestive symptoms the most commonly reported complaint. Celery is a recognised food allergen and is a labelled allergen in the EU, so anyone with a celery allergy should avoid this extract entirely. It may also interact with some medications. Celery3nB is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Celery3nB interact with any medications?

Possible interactions include: Blood pressure medication: celery seed extract measurably lowered blood pressure in the trial, so it can add to the effect of these drugs and push pressure too low. Talk to your doctor before combining them. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Celery3nB?

NutraSmarts rates the evidence for Celery3nB as Limited (2 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

Shayani Rad M, Moohebati M, Mohajeri SA Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over, clinical trial Phytotherapy Research. 2022;36(7):2889-2907. doi:10.1002/ptr.7488.PubMedUsed to support: Triple-blind crossover RCT in hypertensive patients showing celery seed extract significantly reduced systolic and diastolic blood pressure; systolic fell from 141.2 to 130.0 mmHg and diastolic from 92.2 to 84.2 mmHg in 52 patients. Important limits: the Celery3nB brand is not named anywhere in the paper, the product tested was a generic celery seed extract, and every participant had diagnosed hypertension
Shayani Rad M, Moohebati M, Mohajeri SA Beneficial effects of celery seed extract (Apium graveolens), as a supplement, on anxiety and depression in hypertensive patients: a randomized clinical trial Inflammopharmacology. 2023;31(1):395-410. doi:10.1007/s10787-022-01048-3.PubMedUsed to support: Randomized trial measuring anxiety and depression scores in patients already diagnosed with high blood pressure. Anxiety and depression are clinical conditions, so this is not evidence of a mood or well-being benefit for a healthy person, and the extract tested was a generic celery seed extract rather than Celery3nB
Alobaidi S, Saleh E Antihypertensive Property of Celery: A Narrative Review on Current Knowledge International Journal of Food Science. 2024;2024:9792556. doi:10.1155/2024/9792556.PubMedUsed to support: Narrative review summarizing the antihypertensive mechanisms of celery and its active phthalide constituents including 3-n-butylphthalide; this is a narrative review, meaning it summarises other researchers' work rather than adding any new clinical evidence, and it did not test Celery3nB

Celery3nB® (Celery Seed Extract Standardized to 3nB)

Benefits

Blood pressure support

Uric acid: a laboratory idea, not a proven benefit

Honest evidence note

Mechanism of action

3nB vasorelaxation

Xanthine oxidase inhibition

Clinical trials

Side effects and drug interactions

Common Potential side effects

Important Drug interactions

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Frequently asked questions about Celery3nB® (Celery Seed Extract Standardized to 3nB)