Home Ingredients Celery3nB® (Celery Seed Extract Standardized to 3nB)
CardiovascularJoint Health

Celery3nB® (Celery Seed Extract Standardized to 3nB)

Apium graveolens
Evidence Level
Limited
0 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

Celery3nB® is a celery (Apium graveolens) seed extract standardized for 3-n-butylphthalide (3nB), the compound that gives celery its aroma and much of its traditional use for blood pressure and joint comfort. It is positioned for healthy blood pressure and uric-acid support, though human clinical evidence is still limited.

Studied Dose Commonly around 75 to 150 mg of standardized extract per day.
Active Compound Celery seed extract standardized to 3-n-butylphthalide (3nB).

Benefits

Blood pressure support

Celery seed and its 3nB compound have been studied for supporting healthy blood pressure, with promising results in small trials and animal research.

Uric-acid and joint comfort

3nB is studied for inhibiting xanthine oxidase, the enzyme that makes uric acid, supporting joint comfort related to uric-acid balance.

Honest evidence note

Human clinical data for standardized celery seed extract are limited and mostly from small studies, so benefits should be viewed with realistic expectations.

Mechanism of action

1

3nB vasorelaxation

3-n-butylphthalide is thought to relax blood-vessel walls and modulate calcium handling, supporting healthy blood pressure.

2

Xanthine oxidase inhibition

3nB is studied for lowering uric-acid production by inhibiting xanthine oxidase.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — digestive symptoms are most common.
Celery-allergic individuals should avoid this extract.
Can increase sensitivity to sunlight in some people.

Important Drug interactions

Blood pressure medication — possible additive effect; monitor.
Diuretics — celery has a mild diuretic effect; monitor.
Anticoagulants — use caution; tell your doctor.

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Frequently asked questions about Celery3nB® (Celery Seed Extract Standardized to 3nB)

What is Celery3nB?

Celery3nB® is a celery (Apium graveolens) seed extract standardized for 3-n-butylphthalide (3nB), the compound that gives celery its aroma and much of its traditional use for blood pressure and joint comfort.

What is Celery3nB used for?

Celery3nB is researched primarily for Cardiovascular and Joint Health. Celery seed and its 3nB compound have been studied for supporting healthy blood pressure, with promising results in small trials and animal research.

What is the recommended dosage of Celery3nB?

The clinically studied dose is Commonly around 75 to 150 mg of standardized extract per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Celery3nB safe, and does it have side effects?

For most healthy adults, Celery3nB is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — digestive symptoms are most common. Celery-allergic individuals should avoid this extract. It may also interact with some medications. Celery3nB is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Celery3nB interact with any medications?

Possible interactions include: Blood pressure medication — possible additive effect; monitor. Diuretics — celery has a mild diuretic effect; monitor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Celery3nB?

NutraSmarts rates the evidence for Celery3nB as Limited (2 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Shayani Rad M, Moohebati M, Mohajeri SA Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over, clinical trial Phytotherapy Research. 2022;36(7):2889-2907. doi:10.1002/ptr.7488.PubMedUsed to support: Triple-blind crossover RCT in hypertensive patients showing celery seed extract significantly reduced systolic and diastolic blood pressure; directly supports blood pressure benefit of Celery3nB (component-level: celery seed extract standardized for 3nB)
  2. Shayani Rad M, Moohebati M, Mohajeri SA Beneficial effects of celery seed extract (Apium graveolens), as a supplement, on anxiety and depression in hypertensive patients: a randomized clinical trial Inflammopharmacology. 2023;31(1):395-410. doi:10.1007/s10787-022-01048-3.PubMedUsed to support: RCT demonstrating celery seed extract supplementation significantly reduced anxiety and depression scores in hypertensive patients alongside blood pressure reduction; supports well-being and blood pressure benefits of Celery3nB (component-level: celery seed standardized extract)
  3. Alobaidi S, Saleh E Antihypertensive Property of Celery: A Narrative Review on Current Knowledge International Journal of Food Science. 2024;2024:9792556. doi:10.1155/2024/9792556.PubMedUsed to support: Narrative review summarizing the antihypertensive mechanisms of celery and its active phthalide constituents including 3-n-butylphthalide; supports blood pressure benefit and provides mechanistic context for Celery3nB (component-level)