Home Ingredients CaloriBurn GP® (Grains of Paradise)
Weight Management

CaloriBurn GP® (Grains of Paradise)

Aframomum melegueta
Evidence Level
Limited
2 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

CaloriBurn GP is NNB Nutrition's grains of paradise (Aframomum melegueta) seed extract, standardized to contain 6-paradol along with 6-shogaol and 6-gingerol. In small human trials, grains of paradise extract raised energy expenditure and lowered visceral-fat area; these were short, mostly single-blind studies of fewer than 20 people each, measuring metabolic markers rather than sustained weight loss. The CaloriBurn extract has not been tested head to head against single-compound extracts, so the claim that its three-compound profile works better is not established.

Studied Dose Grains of paradise trials used a single 40 mg acute dose (men), 30 mg/day for 4 weeks (women, visceral fat), and 40 mg/day for 5 weeks (low brown-fat adults).
Active Compound 6-Paradol, 6-Shogaol, 6-Gingerol complex — CaloriBurn GP® by NNB Nutrition (Aframomum melegueta extract)

Benefits

Brown adipose tissue activation

Grains of paradise bioactives activate TRPV1 receptors in brown adipose tissue, triggering thermogenesis via UCP1 upregulation. Human studies show significantly increased whole-body energy expenditure and reduced visceral fat in the abdominal region after supplementation.

Supported by Trial 1, Trial 2

Metabolic rate increase

A human trial showed grains of paradise extract significantly increased energy expenditure in healthy young women by increasing brown-fat thermogenesis, with energy expenditure measured by indirect calorimetry. Non-stimulant mechanism with no cardiovascular side effects.

Supported by Trial 1, Trial 2

Visceral fat reduction

A 4-week crossover trial in 19 non-obese young women (Sugita 2014, single-blind) found a significant reduction in visceral-fat area at the umbilicus (measured by CT) versus placebo, with no change in subcutaneous or total fat. This is a visceral-fat surrogate measured in a small study, not sustained body-weight loss.

Supported by Trial 1

Mechanism of action

1

TRPV1 receptor activation

6-Paradol, 6-shogaol, and 6-gingerol are agonists of the TRPV1 (transient receptor potential vanilloid 1) channel — the same receptor activated by capsaicin from hot peppers. TRPV1 activation in adipose tissue and the enteric nervous system triggers thermogenic responses via the sympathetic nervous system.

2

UCP1 expression and BAT activation

TRPV1 activation triggers intracellular calcium flux in brown adipocytes, stimulating UCP1 expression and mitochondrial uncoupling — the process by which brown fat generates heat by burning calories rather than storing ATP.

3

Mitochondrial biogenesis stimulation

Grains of paradise compounds promote mitochondrial biogenesis in adipose tissue via PGC-1α upregulation, increasing the metabolic capacity of brown and beige fat depots over time with repeated supplementation.

Clinical trials

1
Grains of Paradise Daily Ingestion and Energy Expenditure in Women — RCT
PubMed

Single-blind, randomized, placebo-controlled crossover trial of grains of paradise extract (30 mg/day) vs placebo in 19 non-obese young women (ages 20-22) for 4 weeks. Outcomes: whole-body energy expenditure (indirect calorimetry), visceral fat area (CT scan). (Sugita et al. 2014, J Nutr Sci Vitaminol)

19 non-obese young women. 4-week crossover.

Daily GP extract significantly increased whole-body energy expenditure and reduced visceral fat area at the umbilicus level vs placebo. Effects negatively correlated with initial visceral fat area (greater effect in those with higher baseline visceral fat). Mechanism via brown adipose tissue (BAT) activation. Note: small sample, single-blind — independent replication in larger samples needed.

2
Grains of Paradise BAT Activation in Men — RCT
PubMed

Randomized, placebo-controlled trial in 19 healthy male volunteers (ages 20-32) examining acute effects of GP extract on whole-body energy expenditure and brown adipose tissue (BAT) activity. BAT activity confirmed via FDG-PET imaging during cold exposure (19°C, 2 hr). (Sugita et al. 2013, Br J Nutr)

19 healthy young men.

GP extract significantly increased energy expenditure in BAT-positive subjects (12 of 19) but not in BAT-negative subjects. Demonstrates that grains of paradise effects are mediated through BAT activation. Practical implication: efficacy may depend on individual BAT presence — typically more abundant in younger, leaner individuals.

Side effects and drug interactions

Common Potential side effects

Very well tolerated at 40 mg clinical dose
GI discomfort possible at higher doses with some whole grains of paradise extracts — CaloriBurn's purity minimizes this
Mild warming sensation is expected and normal — indication of thermogenic activity

Important Drug interactions

Thermogenic medications or supplements — additive heat-generating effects; monitor in hot environments
Antihypertensive medications — mild sympathomimetic activity; monitor blood pressure
Anticoagulants — gingerol compounds may mildly affect platelet aggregation; monitor with warfarin

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Frequently asked questions about CaloriBurn GP® (Grains of Paradise)

What is CaloriBurn GP?

CaloriBurn GP is NNB Nutrition's grains of paradise (Aframomum melegueta) seed extract, standardized to contain 6-paradol along with 6-shogaol and 6-gingerol. In small human trials, grains of paradise extract raised energy expenditure and lowered visceral-fat area; these were short, mostly single-blind studies of fewer…

What is CaloriBurn GP used for?

CaloriBurn GP is researched primarily for Weight Management. Grains of paradise bioactives activate TRPV1 receptors in brown adipose tissue, triggering thermogenesis via UCP1 upregulation.

What is the recommended dosage of CaloriBurn GP?

The clinically studied dose is Grains of paradise trials used a single 40 mg acute dose (men), 30 mg/day for 4 weeks (women, visceral fat), and 40 mg/day for 5 weeks (low brown-fat adults). Always follow the product label and check with a healthcare provider for personal advice.

Is CaloriBurn GP safe, and does it have side effects?

For most healthy adults, CaloriBurn GP is well tolerated at studied doses. Reported effects can include: Very well tolerated at 40 mg clinical dose GI discomfort possible at higher doses with some whole grains of paradise extracts — CaloriBurn's purity minimizes this It may also interact with some medications. CaloriBurn GP is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does CaloriBurn GP interact with any medications?

Possible interactions include: Thermogenic medications or supplements — additive heat-generating effects; monitor in hot environments Antihypertensive medications — mild sympathomimetic activity; monitor blood pressure If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for CaloriBurn GP?

NutraSmarts rates the evidence for CaloriBurn GP as Limited (2 out of 5). It is backed by 2 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Sugita J, Yoneshiro T, Hatano T, Aita S, Ikemoto T, Uchiwa H, et al. Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr. 2013;110(4):733-8. doi: 10.1017/S0007114512005715.PubMedUsed to support: Single-blind crossover study in 19 healthy men (Sugita 2013): a single 40 mg dose of grains of paradise extract raised whole-body energy expenditure, but only in the 12 men with detectable brown fat, not in the 7 without it. This is an acute energy-expenditure measurement in a small sample using a generic extract rather than CaloriBurn GP, with no body-weight outcome.
  2. Sugita J, Yoneshiro T, Sugishima Y, Ikemoto T, Uchiwa H, Suzuki I, Saito M. Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. J Nutr Sci Vitaminol (Tokyo). 2014;60(1):22-7. doi: 10.3177/jnsv.60.22.PubMedUsed to support: Single-blind crossover trial in 19 non-obese young women (Sugita 2014): 30 mg/day of grains of paradise extract for 4 weeks raised whole-body energy expenditure and reduced visceral-fat area versus placebo, with no change in subcutaneous or total fat. Small study of metabolic surrogates, not sustained body-weight loss, using a generic extract rather than CaloriBurn GP.
  3. Sudeep HV, Aman K, Jestin TV, Shyamprasad K. Aframomum melegueta Seed Extract with Standardized Content of 6-Paradol Reduces Visceral Fat and Enhances Energy Expenditure in Overweight Adults - A Randomized Double-Blind, Placebo-Controlled Clinical Study. Drug Des Devel Ther. 2022;16:3777-3791. doi: 10.2147/DDDT.S367350.PubMedUsed to support: Double-blind RCT in 70 overweight adults (Sudeep 2022): 500 mg/day (250 mg twice daily) of a different grains of paradise extract, AfperFit, standardized for 6-paradol only, over 12 weeks lowered visceral fat and body weight versus placebo. This trial was run and funded by the extract's maker (Vidya Herbs), tested a competitor product at more than ten times CaloriBurn's dose, and did not test CaloriBurn GP.
  4. Yoneshiro T, Matsushita M, Sugita J, Aita S, Kameya T, Sugie H, Saito M. Prolonged Treatment with Grains of Paradise (Aframomum melegueta) Extract Recruits Adaptive Thermogenesis and Reduces Body Fat in Humans with Low Brown Fat Activity. J Nutr Sci Vitaminol (Tokyo). 2021;67(2):99-104. doi: 10.3177/jnsv.67.99.PubMedUsed to support: Single-blind crossover study in 9 men with low brown-fat activity (Yoneshiro 2021): 40 mg/day of grains of paradise extract for 5 weeks raised cold-induced thermogenesis and slightly lowered body-fat percentage, but did not change resting energy expenditure, body weight, or fat-free mass. Very small study of a thermogenesis surrogate, using a generic extract rather than CaloriBurn GP.