Home Ingredients BiovaDerm® (Water-Soluble Eggshell Membrane for Skin — Biova)
Hair, Skin & Nails

BiovaDerm® (Water-Soluble Eggshell Membrane for Skin — Biova)

Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

BiovaDerm® is a water-soluble eggshell membrane from Biova, developed for skin health. The eggshell membrane naturally contains collagen, elastin, hyaluronic acid, and glycosaminoglycans, the same materials found in skin. Composition is not the same as effect: eaten protein is digested into amino acids and peptides before any of it could reach skin. No published human trial has tested BiovaDerm for a skin outcome.

Studied Dose Around 300 to 500 mg per day, a range borrowed from trials of other eggshell membrane products. No dose of BiovaDerm itself has been studied.
Active Compound Water-soluble eggshell membrane providing collagen, elastin, hyaluronic acid, and glycosaminoglycans.

Benefits

Skin support

Eggshell membrane supplies collagen, elastin, and hyaluronic acid, the same materials that make up skin. That describes what the membrane contains, not what it does once you swallow it; eaten protein is digested into amino acids and short peptides. No human trial has measured skin firmness or hydration with BiovaDerm.

Connective-tissue building blocks

The membrane contains glycosaminoglycans, which are also found in connective tissue. Nothing cited here shows that swallowing them builds or maintains connective tissue, and the two joint trials on this page tested other companies' products, not BiovaDerm.

What the research shows so far

No published trial has tested BiovaDerm for skin tone, moisture retention, or any other skin measure. The nearest evidence is a randomized trial of a different product: 300 mg per day of a fresh eggshell membrane from another supplier improved skin firmness and elasticity after 57 days, versus placebo and versus 8,000 mg of hydrolyzed collagen. Processing changes a protein material, so that result cannot be assumed to carry over here.

Mechanism of action

1

Collagen and elastin supply

Eggshell membrane is a source of collagen and elastin protein. Digestion breaks that protein down into amino acids and short peptides, so delivery to the skin's structural matrix is a proposed route rather than a demonstrated one, and it has not been tested for this ingredient.

2

Hyaluronic acid and GAG support

The membrane contains hyaluronic acid and glycosaminoglycans, the moisture-binding molecules of skin and connective tissue. Whether taking them by mouth changes those components in skin has not been tested for this ingredient.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Made from egg, so it carries egg proteins. Tolerability has not been reported for BiovaDerm itself; a knee joint trial of a different eggshell membrane product reported no serious adverse events over 8 weeks.
Mild digestive upset is occasionally reported.
Avoid if you have an egg allergy.

Important Drug interactions

No drug interactions are established for this ingredient, mainly because no interaction studies have been done.
Tell your doctor about all supplements if you take prescription medication.
Use caution if pregnant, breastfeeding, or managing a health condition.

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Frequently asked questions about BiovaDerm® (Water-Soluble Eggshell Membrane for Skin — Biova)

What is BiovaDerm?

BiovaDerm® is a water-soluble eggshell membrane from Biova, developed for skin health. The eggshell membrane naturally contains collagen, elastin, hyaluronic acid, and glycosaminoglycans, the same materials found in skin.

What is BiovaDerm used for?

BiovaDerm is researched primarily for Hair, Skin & Nails. Eggshell membrane supplies collagen, elastin, and hyaluronic acid, the same materials that make up skin. That describes what the membrane contains, not what it does once you swallow it; eaten protein is digested into amino acids and short p…

What is the recommended dosage of BiovaDerm?

The clinically studied dose is Around 300 to 500 mg per day, a range borrowed from trials of other eggshell membrane products. No dose of BiovaDerm itself has been studied. Always follow the product label and check with a healthcare provider for personal advice.

Is BiovaDerm safe, and does it have side effects?

For most healthy adults, BiovaDerm is well tolerated at studied doses. Reported effects can include: Made from egg, so it carries egg proteins. Tolerability has not been reported for BiovaDerm itself; a knee joint trial of a different eggshell membrane product reported no serious adverse events over 8 weeks. Mild digestive upset is occasionally reported. It may also interact with some medications. BiovaDerm is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does BiovaDerm interact with any medications?

Possible interactions include: No drug interactions are established for this ingredient, mainly because no interaction studies have been done. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for BiovaDerm?

NutraSmarts rates the evidence for BiovaDerm as Preliminary (1 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Ruff KJ, Winkler A, Jackson RW, DeVore DP, Ritz BW Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study Clinical Rheumatology. 2009;28(8):907-14. doi:10.1007/s10067-009-1173-4.PubMedUsed to support: Randomized trial in 67 people with knee osteoarthritis of a different eggshell membrane product, Natural Eggshell Membrane (NEM), at 500 mg per day for 8 weeks. The pain and stiffness subscales improved versus placebo, while the overall WOMAC score and the function subscale did not reach significance. No skin outcome was measured and BiovaDerm was not tested, so this paper does not support any claim on this page.
  2. Cánovas F, Abellán-Ruíz MS, García-Muñoz AM, Luque-Rubia AJ, Victoria-Montesinos D, Pérez-Piñero S, Sánchez-Macarro M, López-Román FJ Randomised Clinical Trial to Analyse the Efficacy of Eggshell Membrane to Improve Joint Functionality in Knee Osteoarthritis Nutrients. 2022;14(11):2340. doi:10.3390/nu14112340.PubMedUsed to support: Randomized trial in 80 people with knee osteoarthritis of Ovomet, a processed eggshell membrane from another supplier, given at 300 or 500 mg per day for 8 weeks. Outcomes were knee pain, knee function, quadriceps strength and sleep quality. No skin outcome was measured and BiovaDerm was not tested, so this paper does not support any claim on this page.
  3. González-Rodríguez Y, La Nuez-García MA, Jiménez M, Villar-Suárez V, Casado-Santos A Comparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties: a randomized clinical trial Frontiers in Nutrition. 2026;12:1689701. doi:10.3389/fnut.2025.1689701.PubMedUsed to support: Randomized trial of MKARE, a fresh eggshell membrane from a different supplier, in people showing signs of aging. Participants took 300 mg per day of MKARE, 8,000 mg per day of hydrolyzed collagen, or placebo, with skin assessed by Cutometer, Tewameter, Corneometer and VISIA at 28 and 57 days. Firmness, flexibility and elasticity improved at 57 days versus both comparators. The abstract does not report how many people took part, and two of the authors were employed by commercial companies. This is the only skin trial cited here and it tests a different product made by a different process, so it is borrowed evidence, not evidence for BiovaDerm.