Benefits
Carbohydrate and weight management
In a single open-label pilot in mildly overweight adults, the group taking the standardized bean extract lost more weight over 12 weeks than a diet-only group. There was no placebo control and subjects were not blinded, so the size of the extract's own effect is uncertain.
Post-meal blood sugar (mechanism only, not measured in the cited trial)
By slowing starch breakdown, the extract may reduce the rise in blood sugar after a starchy meal. Postprandial glucose was not measured in the single Beanblock trial, so this is a proposed mechanism rather than a demonstrated effect for this extract.
Appetite and intake support
Slower carbohydrate absorption is associated with steadier energy and may support a feeling of fullness after meals.
Mechanism of action
Alpha-amylase inhibition
Phaseolamin binds to the digestive enzyme alpha-amylase, temporarily reducing its ability to break dietary starch into absorbable sugars.
Reduced starch absorption
With less starch digested in the upper gut, a portion passes further along, lowering the immediate caloric and glycemic load of the meal.
Clinical trials
Open-label pilot in 60 mildly overweight subjects: 30 took Beanblock (50 mg twice daily) for 12 weeks, 30 followed the diet plan only, with no placebo control or blinding. (Luzzi et al. 2014, European Review for Medical and Pharmacological Sciences)
Mildly overweight adults.
Over 12 weeks the Beanblock group lost more body weight (about 4 kg) and waist circumference (about 6 cm) than the diet-only group, which changed only marginally. Because there was no placebo and no blinding, part of this difference may reflect the open-label design.