Home Ingredients AquaLOX® (Water-Soluble Boswellia AKBA — PLT Health)
Joint HealthAnti-Inflammatory

AquaLOX® (Water-Soluble Boswellia AKBA — PLT Health)

Boswellia serrata
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

AquaLOX® is a water-soluble form of PLT Health Solutions' clinically studied 5-LOXIN Boswellia serrata extract, enriched to about 30% AKBA (acetyl-keto-boswellic acid). It supports joint comfort and a balanced inflammatory response, in a pleasant-tasting form suited to gummies, shots, and drinks.

Studied Dose Around 100 to 250 mg of the standardized extract per day.
Active Compound Boswellia serrata extract enriched to about 30% AKBA (3-O-acetyl-11-keto-beta-boswellic acid), water-soluble.

Benefits

Joint comfort

Boswellia extracts enriched for AKBA are studied for improving joint comfort and physical function in people with knee osteoarthritis.

Supported by Trial 1

Balanced inflammation

AKBA supports a balanced inflammatory response, the basis for boswellia's joint benefits.

Supported by Trial 1

Cartilage protection

5-LOXIN has been studied for helping protect cartilage from degradation enzymes.

Supported by Trial 1

Mechanism of action

1

5-lipoxygenase inhibition

AKBA inhibits the 5-lipoxygenase (5-LOX) enzyme, reducing pro-inflammatory leukotrienes that drive joint inflammation.

2

Cartilage-enzyme support

Boswellic acids are studied for reducing the activity of enzymes (such as MMPs) that break down cartilage.

Clinical trials

1
5-LOXIN for Knee Osteoarthritis — RCT
PubMed

Double-blind, randomized, placebo-controlled study of 5-LOXIN (AKBA-enriched Boswellia serrata) for knee osteoarthritis. (Sengupta et al. 2008, Arthritis Research & Therapy)

Adults with knee osteoarthritis.

5-LOXIN improved joint pain and function versus placebo; AquaLOX is the water-soluble form of 5-LOXIN.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anti-inflammatory medication — tell your doctor if combining.
May interact with drugs processed by the liver; ask your doctor.
Use caution if pregnant or breastfeeding.

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Frequently asked questions about AquaLOX® (Water-Soluble Boswellia AKBA — PLT Health)

What is AquaLOX?

AquaLOX® is a water-soluble form of PLT Health Solutions' clinically studied 5-LOXIN Boswellia serrata extract, enriched to about 30% AKBA (acetyl-keto-boswellic acid). It supports joint comfort and a balanced inflammatory response, in a pleasant-tasting form suited to gummies, shots, and drinks.

What is AquaLOX used for?

AquaLOX is researched primarily for Joint Health and Anti-Inflammatory. Boswellia extracts enriched for AKBA are studied for improving joint comfort and physical function in people with knee osteoarthritis.

What is the recommended dosage of AquaLOX?

The clinically studied dose is Around 100 to 250 mg of the standardized extract per day. Always follow the product label and check with a healthcare provider for personal advice.

Is AquaLOX safe, and does it have side effects?

For most healthy adults, AquaLOX is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild digestive upset is occasionally reported. It may also interact with some medications. AquaLOX is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does AquaLOX interact with any medications?

Possible interactions include: Anti-inflammatory medication — tell your doctor if combining. May interact with drugs processed by the liver; ask your doctor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for AquaLOX?

NutraSmarts rates the evidence for AquaLOX as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10(4):R85..PubMedUsed to support: RCT of AKBA-enriched Boswellia serrata (5-LOXIN) for knee osteoarthritis (AquaLOX is the water-soluble 5-LOXIN).