Home Ingredients AnaGain™ Nu (Organic Pea Sprout Extract)
Hair, Skin & Nails

AnaGain™ Nu (Organic Pea Sprout Extract)

Pisum sativum
Evidence Level
Limited
2 Clinical Trials
4 Documented Benefits
2/5 Evidence Score

AnaGain™ Nu is the oral (nutraceutical) grade of Mibelle Biochemistry's pea-sprout hair active — a water-soluble extract of organic germinated pea (Pisum sativum) sprouts. The proposed mechanism is rebalancing the hair-growth cycle by stimulating dermal papilla cells and upregulating the anagen-promoting signals FGF7 and Noggin; the sprouts are also rich in L-arginine, which supports scalp microcirculation. Honest framing: the supporting clinical study is a small, manufacturer-run short communication, so AnaGain Nu is best described as an emerging, mechanism-backed hair ingredient rather than a heavily proven one. The 'Nu' suffix marks Mibelle's ingestible line, distinct from the original topical AnaGain.

Studied Dose 100 mg/day of AnaGain™ Nu, the oral dose used by Mibelle in its intake study. Typically taken as a capsule or in a beauty-from-within powder/drink.
Active Compound Water-soluble actives from organic germinated pea (Pisum sativum) sprouts, including signaling peptides/metabolites that upregulate FGF7 and Noggin, plus a high L-arginine content. AnaGain™ Nu is manufactured by Mibelle Biochemistry.

Benefits

Reduced hair shedding and improved density (branded study)

In Mibelle's oral intake study, 100 mg/day pea-sprout extract reduced hair loss in volunteers, with benefits emerging within weeks. Honest framing: this is a small, manufacturer-run short-communication study, so it supports rather than proves the effect.

Supported by Trial 1

Reactivates the hair growth (anagen) phase

Pea sprout extract upregulates FGF7 (keratinocyte growth factor) and Noggin, two signals that push hair follicles from the resting (telogen) phase back into the active growth (anagen) phase. A 2025 mechanistic study independently reported that pea-sprout extract promotes follicle regeneration by prolonging anagen.

Supported by Trial 2

L-arginine for scalp microcirculation

Germinated pea sprouts are high in L-arginine, a precursor to nitric oxide, which supports blood flow to the dermal papilla — the nutrient-delivery base of each follicle.

Supported by Trial 2

Vegan, food-derived and well tolerated

As a water-soluble extract of an edible legume sprout, AnaGain Nu is vegan and has a reassuring tolerability profile, suitable for beauty-from-within supplements and drinks.

Supported by Trial 2, Trial 1

Mechanism of action

1

FGF7 and Noggin upregulation

By enhancing expression of FGF7 and Noggin in dermal papilla cells, pea-sprout extract favors the anagen (growth) phase of the hair cycle and counters the shift toward telogen (shedding) that drives thinning.

2

Dermal papilla stimulation

The dermal papilla orchestrates the hair cycle; AnaGain Nu acts directly on these cells to rebalance growth signaling rather than acting on hormones.

3

L-arginine and microcirculation

High L-arginine content supports nitric-oxide-mediated microcirculation at the scalp, improving delivery of oxygen and nutrients to active follicles.

Clinical trials

1
Oral Pea-Sprout Extract Hair Study (branded)

Grothe T, Wandrey F, Schuerch C. Phytotherapy Research, 2020 (short communication). Mibelle-affiliated authors.

Volunteers with hair loss (small sample)

Oral supplementation with pea-sprout extract (100 mg/day) reduced hair loss over the study period. As a small, manufacturer-run short communication, it is encouraging but limited evidence.

2
Pea-Sprout Extract and Follicle Regeneration (mechanism)

Kim Y et al., Journal of Microbiology and Biotechnology, 2025. Mechanistic.

Preclinical models

Pea-sprout extract promoted hair-follicle regeneration by prolonging the anagen phase via dual mechanisms, independently supporting the proposed mode of action behind AnaGain Nu.

Side effects and drug interactions

Common Potential side effects

Very well tolerated in available data; a vegan, food-derived extract.
People with pea or legume allergy should avoid it.
Mild gastrointestinal upset is possible, as with any concentrated plant extract.
Long-term and large-sample safety data are limited given the small clinical base.
Pregnancy/lactation: not specifically studied; precautionary use is reasonable.

Important Drug interactions

No clinically significant drug interactions are documented.
Allergy caution rather than interaction: avoid with known pea/legume allergy.
Theoretical only: the L-arginine content is modest at supplement doses but, in very large combined arginine intakes, could add to blood-pressure-lowering or nitrate effects.

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Frequently asked questions about AnaGain™ Nu (Organic Pea Sprout Extract)

What is AnaGain Nu?

AnaGain Nu is the oral (ingestible) version of Mibelle's pea-sprout hair ingredient — a water-soluble extract of organic germinated pea (Pisum sativum) sprouts taken at about 100 mg/day to support hair density and reduce shedding from within. The 'Nu' marks Mibelle's nutraceutical line, separate from the topical AnaGain applied to the scalp.

How does pea sprout extract help hair?

It rebalances the hair-growth cycle. Pea-sprout actives upregulate FGF7 and Noggin, signals that move follicles from the resting phase back into the active growth phase, and the sprouts are rich in L-arginine, which supports scalp microcirculation. A 2025 mechanistic study found it prolongs the growth (anagen) phase.

How strong is the evidence for AnaGain Nu?

Moderate-to-early. The mechanism is well characterized and there is a published oral study showing reduced hair loss, but that study is small and manufacturer-run, so AnaGain Nu is best seen as a promising, mechanism-backed ingredient rather than a heavily proven one.

What is AnaGain Nu used for?

AnaGain Nu is researched primarily for Hair, Skin & Nails. In Mibelle's oral intake study, 100 mg/day pea-sprout extract reduced hair loss in volunteers, with benefits emerging within weeks.

What is the recommended dosage of AnaGain Nu?

The clinically studied dose is 100 mg/day of AnaGain™ Nu, the oral dose used by Mibelle in its intake study. Typically taken as a capsule or in a beauty-from-within powder/drink. Always follow the product label and check with a healthcare provider for personal advice.

Is AnaGain Nu safe, and does it have side effects?

For most healthy adults, AnaGain Nu is well tolerated at studied doses. Reported effects can include: Very well tolerated in available data; a vegan, food-derived extract. People with pea or legume allergy should avoid it. It may also interact with some medications. AnaGain Nu is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does AnaGain Nu interact with any medications?

Possible interactions include: No clinically significant drug interactions are documented. Allergy caution rather than interaction: avoid with known pea/legume allergy. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for AnaGain Nu?

NutraSmarts rates the evidence for AnaGain Nu as Limited (2 out of 5). It is backed by 2 clinical trials and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Grothe T, Wandrey F, Schuerch C Short communication: Clinical evaluation of pea sprout extract in the treatment of hair loss. Phytotherapy Research. 2020;34(2):428-431. doi: 10.1002/ptr.6528.PubMedUsed to support: The branded clinical study behind AnaGain Nu: oral pea-sprout extract (100 mg/day) reduced hair loss in volunteers. Honest framing: a small, manufacturer-run short-communication study (Mibelle authors); encouraging but limited.
  2. Kim Y, You SH, Yoon D, Lee JM, Woo MS, Park YJ, et al. Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling. Journal of Microbiology and Biotechnology. 2025;35:e2508011. doi: 10.4014/jmb.2508.08011.PubMedUsed to support: A 2025 mechanistic study showing pea-sprout extract promotes hair-follicle regeneration by prolonging the anagen (growth) phase — independent support for AnaGain Nu's proposed mechanism (FGF7/Noggin signaling).
  3. Zhou L, Zhu W, Chen Y Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis. Frontiers in Nutrition. 2025;12:1719711. doi: 10.3389/fnut.2025.1719711.PubMedUsed to support: A 2025 systematic review and network meta-analysis of oral dietary supplements for androgenetic alopecia, providing independent context for where saw palmetto, anthocyanins, and pea-sprout-type actives sit relative to other hair supplements.