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Aminogen® (Protease Enzyme Blend — Deerland)

Evidence Level
Moderate
2 Clinical Trials
3 Documented Benefits
3/5 Evidence Score

Aminogen® is a patented blend of fungal proteases (protein-digesting enzymes derived from Aspergillus) added to protein powders and meals to improve how well the body breaks down and absorbs protein. By cleaving dietary protein into smaller peptides and free amino acids, it is intended to raise the amount of usable amino acids that reach the bloodstream and to reduce the bloating some people feel after a large protein dose.

Studied Dose Roughly 250 to 500 mg taken with a protein-containing meal or shake.
Active Compound A patented blend of fungal proteases (from Aspergillus species) that hydrolyze dietary protein into peptides and free amino acids.

Benefits

Improved protein digestion

Added to a protein meal, the protease blend increases the breakdown of protein into absorbable amino acids, helping the body get more out of the protein consumed.

Supported by Trial 1, Trial 2

Higher circulating amino acids

Clinical testing found that taking the enzyme with protein raised blood levels of amino acids, including branched-chain amino acids, compared with protein alone.

Supported by Trial 1

Less post-protein bloating

By aiding digestion of large protein loads, the enzyme may reduce the gas and bloating some people experience after protein shakes or high-protein meals.

Supported by Trial 2, Trial 1

Mechanism of action

1

Proteolytic hydrolysis

Fungal proteases cleave the peptide bonds in dietary protein, producing smaller peptides and free amino acids that are easier for the gut to absorb.

2

Acid and heat stability

Aspergillus-derived proteases stay active across a range of stomach and intestinal conditions, allowing them to work alongside the body's own digestive enzymes.

Clinical trials

1
Protease Blend and Amino Acid Absorption — Study
PubMed

Open-label study measuring blood amino acid levels after consuming protein with versus without the Aminogen protease blend. (Oben et al. 2008, Journal of the International Society of Sports Nutrition)

Healthy adults consuming protein.

Taking the protease with protein increased circulating amino acids, including branched-chain amino acids, and nitrogen retention compared with protein alone.

2
Fungal Protease and Protein Digestion — RCT
PubMed

Double-blind clinical study investigating the effects of a fungal protease on the digestion and absorption of dietary protein. (Anderson 2013, Food Digestion)

Healthy adults.

The protease improved markers of protein digestion and amino acid availability versus control, supporting its use as a digestive aid for high-protein intakes.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — digestive enzymes are well tolerated at normal doses.
Mild stomach upset is possible, especially on an empty stomach; take with food.
People with a known mold or fungal allergy should be cautious with fungal-derived enzymes.

Important Drug interactions

No significant drug interactions are established for dietary proteases.
People on protease-inhibitor medications should consult a clinician before use.
As with any supplement, tell your doctor if you manage a digestive condition.

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Frequently asked questions about Aminogen® (Protease Enzyme Blend — Deerland)

What is Aminogen?

Aminogen® is a patented blend of fungal proteases (protein-digesting enzymes derived from Aspergillus) added to protein powders and meals to improve how well the body breaks down and absorbs protein.

What is Aminogen used for?

Aminogen is researched primarily for Gut Health and Muscle & Recovery. Added to a protein meal, the protease blend increases the breakdown of protein into absorbable amino acids, helping the body get more out of the protein consumed.

What is the recommended dosage of Aminogen?

The clinically studied dose is Roughly 250 to 500 mg taken with a protein-containing meal or shake. Always follow the product label and check with a healthcare provider for personal advice.

Is Aminogen safe, and does it have side effects?

For most healthy adults, Aminogen is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — digestive enzymes are well tolerated at normal doses. Mild stomach upset is possible, especially on an empty stomach; take with food. It may also interact with some medications. Aminogen is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Aminogen interact with any medications?

Possible interactions include: No significant drug interactions are established for dietary proteases. People on protease-inhibitor medications should consult a clinician before use. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Aminogen?

NutraSmarts rates the evidence for Aminogen as Moderate (3 out of 5). It is backed by 2 clinical trials and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Oben J, Kothari SC, Anderson ML. An open label study to determine the effects of an oral proteolytic enzyme system on whey protein concentrate metabolism in healthy males. J Int Soc Sports Nutr. 2008;5:10..PubMedUsed to support: Increased circulating amino acids with the protease (protein-digestion benefit).
  2. Anderson ML. A Double-Blind Clinical Study to Investigate the Effects of a Fungal Protease on Protein Digestion. Food Dig. 2013;4(1):19-25..PubMedUsed to support: Controlled evidence the protease improves protein digestion.