Home Ingredients Thymocid® (Black Cumin Seed Extract — Verdure Sciences)
Anti-Inflammatory

Thymocid® (Black Cumin Seed Extract — Verdure Sciences)

Nigella sativa
Evidence Level
Preliminary
1 Clinical Trial
3 Documented Benefits
1/5 Evidence Score

Thymocid® is a black cumin (Nigella sativa) seed ingredient from Verdure Sciences, described by the supplier as a cold pressed, gravity filtered seed oil standardized to fatty acids. Black cumin has a long history in traditional medicine, but the only published research on this specific ingredient is a single laboratory study in cultured mouse cells that looked at skin related measures, not at inflammation or immune function.

Studied Dose No human dose has been established; no trial in people has tested this ingredient. The supplier suggests 500 to 1,000 mg per day, and the only published study applied the extract to cells in a dish at microgram per milliliter concentrations.
Active Compound Standardized Nigella sativa (black cumin) seed ingredient from Verdure Sciences. The supplier describes it as a cold pressed oil standardized to fatty acids, while the one published study describes it as standardized to thymoquinone and reports 5.12 percent in the batch tested.

Benefits

Anti-inflammatory support

Black cumin seed is traditionally associated with calming inflammatory signaling, and thymoquinone is the compound usually credited for it. That is background on the plant rather than a result for this ingredient: the single published study on Thymocid did not measure inflammation of any kind.

Supported by Trial 1

Immune effects in the plant literature

Black cumin seed has been examined for effects on immune markers in the wider literature on the plant. Nothing published on Thymocid itself has measured immune function, so the ingredient's own evidence does not support this.

Supported by Trial 1

Antioxidant defense

Thymoquinone shows antioxidant activity in laboratory tests. The Thymocid study ran no antioxidant assay, so this is a general property of the compound rather than a measured result for this ingredient.

Supported by Trial 1

Mechanism of action

1

Thymoquinone signaling

Thymoquinone inhibits inflammatory mediators and supports antioxidant enzyme systems. This is proposed from work on the isolated compound and has not been shown for this extract in people.

2

Immune modulation

Black cumin compounds have been reported to influence immune-cell activity in laboratory work on the plant. No immune measure has been taken with Thymocid.

Clinical trials

1
Black Cumin Extract — Skin Laboratory Study in Mouse Cells
PubMed

Laboratory study of Thymocid in murine B16F10 melanoma cells and in cell free enzyme assays, testing skin related measures for cosmetic use. Not a clinical trial. (Li et al. 2020, Nutrients)

No people and no animals took part. Cultured mouse melanoma cells and enzyme assays only.

In cell free assays at 50 to 300 micrograms per milliliter the extract reduced advanced glycation end product formation, collagen cross-linking, and collagenase and elastase activity. In the cells at 2.5 to 20 micrograms per milliliter it lowered melanin content by 42.5 to 61.6 percent, a skin lightening effect, and reduced tyrosinase activity. No inflammatory marker and no immune measure were tested, and the authors noted that thymoquinone alone may not account for the effects. Their stated conclusion was that Thymocid has potential as a cosmetic ingredient for skin care products. There is no human data for this extract.

Side effects and drug interactions

Common Potential side effects

No human safety study of this ingredient has been published. Black cumin seed and its oil are widely eaten as food and are generally well tolerated, but tolerability has not been tested for this preparation.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Blood sugar and blood pressure medication — black cumin may lower both; monitor.
Anticoagulants — possible mild additive effect.
Pregnancy and breastfeeding: safety is not established. In animal work, black cumin extract given through pregnancy reduced litter size and lengthened gestation, so avoid unless your doctor advises otherwise. Tell your doctor if you are managing a chronic condition.

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Frequently asked questions about Thymocid® (Black Cumin Seed Extract — Verdure Sciences)

What is Thymocid?

Thymocid® is a black cumin (Nigella sativa) seed ingredient from Verdure Sciences, described by the supplier as a cold pressed, gravity filtered seed oil standardized to fatty acids.

What is Thymocid used for?

Thymocid is researched primarily for Anti-Inflammatory. Black cumin seed is traditionally associated with calming inflammatory signaling, and thymoquinone is the compound usually credited for it.

What is the recommended dosage of Thymocid?

The clinically studied dose is No human dose has been established; no trial in people has tested this ingredient. The supplier suggests 500 to 1,000 mg per day, and the only published study applied the extract to cells in a dish at microgram per milliliter concentrations. Always follow the product label and check with a healthcare provider for personal advice.

Is Thymocid safe, and does it have side effects?

For most healthy adults, Thymocid is well tolerated at studied doses. Reported effects can include: No human safety study of this ingredient has been published. Black cumin seed and its oil are widely eaten as food and are generally well tolerated, but tolerability has not been tested for this preparation. Mild digestive upset is occasionally reported. It may also interact with some medications. Thymocid is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Thymocid interact with any medications?

Possible interactions include: Blood sugar and blood pressure medication — black cumin may lower both; monitor. Anticoagulants — possible mild additive effect. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Thymocid?

NutraSmarts rates the evidence for Thymocid as Preliminary (1 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Li H, DaSilva NA, Liu W, et al. Thymocid, a Standardized Black Cumin (Nigella sativa) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells. Nutrients. 2020;12(7):2146. doi: 10.3390/nu12072146.PubMedUsed to support: A laboratory study in cultured mouse melanoma cells and enzyme assays, testing anti-aging and skin lightening measures intended for cosmetic products. It did not measure inflammation, antioxidant activity or immune function, and no person or animal was involved.