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SiMag® (Sucrosomial® Magnesium)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

SiMag® is a Sucrosomial® form of magnesium, in which the mineral is wrapped in a protective phospholipid-and-sucrester coating to improve absorption and gut tolerance. It delivers well-absorbed magnesium for muscle, nerve, sleep, and bone health with less of the laxative effect of common magnesium salts.

Studied Dose Delivering about 200 to 375 mg of elemental magnesium per day.
Active Compound Sucrosomial magnesium (magnesium oxide within a phospholipid and sucrester matrix).

Benefits

Better-absorbed magnesium

In a comparative crossover study, Sucrosomial magnesium showed favorable bioavailability, delivering magnesium with good tolerance.

Supported by Trial 1

Muscle and nerve support

Magnesium is essential for normal muscle relaxation, nerve signaling, and the reduction of cramps and tension.

Supported by Trial 1

Sleep and bone support

Adequate magnesium supports restful sleep, a calm nervous system, and healthy bones, where most of the body's magnesium is stored.

Supported by Trial 1

Mechanism of action

1

Protected absorption

The Sucrosomial coating shields magnesium through the stomach and helps it cross the intestinal wall efficiently, with less unabsorbed mineral to cause loose stools.

2

Enzyme cofactor

Magnesium is a cofactor for hundreds of enzymes governing energy production, muscle function, and nerve transmission.

Clinical trials

1
Sucrosomial Magnesium Bioavailability — Crossover Study
PubMed

Ex-vivo and comparative double-blind crossover study of magnesium bioavailability after Sucrosomial magnesium. (Brilli et al. 2018, European Review for Medical and Pharmacological Sciences)

Healthy subjects.

Sucrosomial magnesium demonstrated favorable magnesium bioavailability in the comparative study.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — better tolerated than many magnesium salts.
High doses can still cause loose stools.
Reduce the dose if digestive upset occurs.

Important Drug interactions

Antibiotics (tetracyclines, quinolones) and bisphosphonates — magnesium can reduce absorption; separate by 2 hours.
Severe kidney disease — consult a doctor before magnesium supplements.
Tell your doctor about all medications.

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Frequently asked questions about SiMag® (Sucrosomial® Magnesium)

What is SiMag® (Sucrosomial® Magnesium)?

SiMag® is a Sucrosomial® form of magnesium, in which the mineral is wrapped in a protective phospholipid-and-sucrester coating to improve absorption and gut tolerance. It delivers well-absorbed magnesium for muscle, nerve, sleep, and bone health with less of the laxative effect of common magnesium salts.

What is the recommended dosage of SiMag® (Sucrosomial® Magnesium)?

The clinically studied dose for SiMag® (Sucrosomial® Magnesium) is Delivering about 200 to 375 mg of elemental magnesium per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is SiMag® (Sucrosomial® Magnesium) used for?

SiMag® (Sucrosomial® Magnesium) is studied for better-absorbed magnesium, muscle and nerve support, sleep and bone support. In a comparative crossover study, Sucrosomial magnesium showed favorable bioavailability, delivering magnesium with good tolerance.

Are there side effects from taking SiMag® (Sucrosomial® Magnesium)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — better tolerated than many magnesium salts. High doses can still cause loose stools. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is SiMag® (Sucrosomial® Magnesium) safe to take?

Whether SiMag® (Sucrosomial® Magnesium) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — better tolerated than many magnesium salts. It may also interact with certain medications. SiMag® (Sucrosomial® Magnesium) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Brilli E, Khadge S, Fabiano A, et al. Magnesium bioavailability after administration of sucrosomial magnesium: results of an ex-vivo study and a comparative, double-blinded, cross-over study in healthy subjects. Eur Rev Med Pharmacol Sci. 2018;22(6):1843-1851..PubMedUsed to support: Crossover study supporting bioavailability of Sucrosomial magnesium.