SiMag® (Sucrosomial® Magnesium)

SiMag® is a Sucrosomial® form of magnesium, in which the mineral is wrapped in a protective phospholipid-and-sucrester coating to improve absorption (and, per the manufacturer, gut tolerance).

SiMag is researched primarily for Muscle & Recovery, Sleep Health, and Bone Health. In a comparative crossover study, Sucrosomial magnesium showed favorable bioavailability, raising blood and urine magnesium in healthy subjects in a single industry-sponsored study.

The clinically studied dose is Delivering about 200 to 375 mg of elemental magnesium per day. Always follow the product label and check with a healthcare provider for personal advice.

For most healthy adults, SiMag is well tolerated at studied doses. Reported effects can include: Generally well-tolerated; the manufacturer suggests it may be better tolerated than some magnesium salts, though this rests on limited data. High doses can still cause loose stools. It may also interact with some medications. SiMag is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Possible interactions include: Antibiotics (tetracyclines, quinolones) and bisphosphonates — magnesium can reduce absorption; separate by 2 hours. Severe kidney disease — consult a doctor before magnesium supplements. If you take prescription medication, check with a pharmacist or doctor before using it.

NutraSmarts rates the evidence for SiMag as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.