Home Ingredients OxiCyan® (Bilberry and Spirulina Antioxidant Complex — Biosfered)
Antioxidant

OxiCyan® (Bilberry and Spirulina Antioxidant Complex — Biosfered)

Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

OxiCyan is a branded ingredient blend from Biosfered that combines bilberry (Vaccinium myrtillus) anthocyanins with spirulina (Arthrospira platensis) phycocyanin. The idea that the two ingredients work together is the manufacturer's rationale, not a tested finding: no published human trial has studied the OxiCyan blend itself. The four studies cited here are two review articles, one placebo-controlled trial of a different company's branded bilberry extract in people with dry eye, and one crossover trial of plain spirulina in exercising adults.

Studied Dose No dose of OxiCyan has been tested in a published human trial. Products typically supply a few hundred milligrams per day, but that figure comes from labels, not from research.
Active Compound Bilberry anthocyanins plus spirulina phycocyanin, along with carotenoids.

Benefits

Antioxidant defense

The 'dual action' story is the reason the two ingredients were combined, not something anyone has tested as a blend. Studied separately in people: a randomized crossover trial of plain spirulina raised glutathione at rest and after exercise and lowered TBARS, a marker of exercise-related fat damage; and a placebo-controlled trial of Mirtoselect, a different company's bilberry extract, improved a blood antioxidant measure in people with dry eye. Neither trial used OxiCyan.

Cellular protection

No laboratory study of the OxiCyan complex is cited on this page. The cell-protection idea comes from two review articles that summarize laboratory work on bilberry anthocyanins and on spirulina pigments as separate ingredients.

Limited-evidence note

There are no human trials of OxiCyan itself. The four references on this page are two review articles, one trial of a competing branded bilberry extract in people with dry eye, and one trial of unbranded spirulina in exercising adults. Nothing cited here shows what this specific blend does in a person.

Mechanism of action

1

Neutralizing free radicals (laboratory evidence)

In laboratory work summarized by a 2022 bilberry review, anthocyanins neutralize reactive oxygen species, the unstable molecules behind oxidative stress. How much of this happens in the body at supplement doses, and whether it matters to how you feel, has not been established for this blend.

2

Switching on the cell's own antioxidant enzymes

Laboratory and animal studies summarized in a 2016 spirulina review suggest that phycocyanin and other spirulina pigments prompt cells to increase their own antioxidant enzymes, through a signalling route called Nrf2. This is cell and animal work, not evidence from people taking OxiCyan.

Clinical trials

Side effects and drug interactions

Common Potential side effects

OxiCyan itself has never been assessed for safety in a published trial. Bilberry and spirulina are both widely consumed and generally well tolerated on their own.
Mild digestive upset is occasionally reported.
Spirulina grown in poorly controlled conditions can carry microcystin toxins or heavy metals, so choose a product that has been third-party tested for purity.

Important Drug interactions

Blood thinners such as warfarin: bilberry may mildly add to their effect. Talk to your doctor before combining them.
Autoimmune conditions: spirulina may stimulate the immune system, so check with your doctor before taking it.
This blend has not been studied in pregnancy or breastfeeding, so ask your doctor before using it.

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Frequently asked questions about OxiCyan® (Bilberry and Spirulina Antioxidant Complex — Biosfered)

What is OxiCyan?

OxiCyan is a branded ingredient blend from Biosfered that combines bilberry (Vaccinium myrtillus) anthocyanins with spirulina (Arthrospira platensis) phycocyanin.

What is OxiCyan used for?

OxiCyan is researched primarily for Antioxidant. The 'dual action' story is the reason the two ingredients were combined, not something anyone has tested as a blend. Studied separately in people: a randomized crossover trial of plain spirulina raised glutathione at rest and after exercise…

What is the recommended dosage of OxiCyan?

The clinically studied dose is No dose of OxiCyan has been tested in a published human trial. Products typically supply a few hundred milligrams per day, but that figure comes from labels, not from research. Always follow the product label and check with a healthcare provider for personal advice.

Is OxiCyan safe, and does it have side effects?

For most healthy adults, OxiCyan is well tolerated at studied doses. Reported effects can include: OxiCyan itself has never been assessed for safety in a published trial. Bilberry and spirulina are both widely consumed and generally well tolerated on their own. Mild digestive upset is occasionally reported. It may also interact with some medications. OxiCyan is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does OxiCyan interact with any medications?

Possible interactions include: Blood thinners such as warfarin: bilberry may mildly add to their effect. Talk to your doctor before combining them. Autoimmune conditions: spirulina may stimulate the immune system, so check with your doctor before taking it. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for OxiCyan?

NutraSmarts rates the evidence for OxiCyan as Preliminary (1 out of 5). It is backed by 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Riva A, Togni S, Franceschi F, Kawada S, Inaba Y, Eggenhoffner R, Giacomelli L The effect of a natural, standardized bilberry extract (Mirtoselect®) in dry eye: a randomized, double blinded, placebo-controlled trial European Review for Medical and Pharmacological Sciences. 2017;21(10):2518-2525.PubMedUsed to support: This is a randomized, double blind, placebo-controlled trial of Mirtoselect, a competing company's branded bilberry extract, carried out in people with dry eye. It reported a significant improvement in a blood antioxidant measure (BAP assay, p=0.003) compared with placebo. Because it tested a different branded product in a patient group, it is not evidence for what OxiCyan does, and it does not show that OxiCyan helps anyone's eyes.
  2. Sharma A, Lee HJ Anti-Inflammatory Activity of Bilberry (Vaccinium myrtillus L.) Current Issues in Molecular Biology. 2022;44(10):4570-4583. doi:10.3390/cimb44100313.PubMedUsed to support: This is a review article, not a study. It gathers other researchers' laboratory and human findings on the anti-inflammatory activity of bilberry anthocyanins. A review cannot demonstrate an effect on its own, and this one is about bilberry as a raw material, not about OxiCyan.
  3. Kalafati M, Jamurtas AZ, Nikolaidis MG, Paschalis V, Theodorou AA, Sakellariou GK, Koutedakis Y, Kouretas D Ergogenic and antioxidant effects of spirulina supplementation in humans Medicine and Science in Sports and Exercise. 2010;42(1):142-51. doi:10.1249/MSS.0b013e3181ac7a45.PubMedUsed to support: A randomized crossover trial in humans of plain, unbranded spirulina, not OxiCyan. Spirulina raised glutathione levels at rest and after exercise and reduced TBARS, a marker of exercise-related fat damage. It tested a different product in an exercise setting, so it tells you about spirulina generally rather than about this blend.
  4. Wu Q, Liu L, Miron A, Klímová B, Wan D, Kuča K The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview Archives of Toxicology. 2016;90(8):1817-40. doi:10.1007/s00204-016-1744-5.PubMedUsed to support: This is a review article, not a study. It summarizes mainly laboratory and animal evidence that spirulina pigments such as phycocyanin scavenge free radicals and support cells' own antioxidant enzymes. It is background reading on spirulina as an ingredient, not evidence that the OxiCyan blend does any of this in people.