Home Ingredients Neumentix® (Spearmint Extract — Kemin)
Cognitive

Neumentix® (Spearmint Extract — Kemin)

Mentha spicata
Evidence Level
Moderate
2 Clinical Trials
6 Documented Benefits
3/5 Evidence Score

Neumentix® is the branded standardized spearmint extract from Kemin Industries (Iowa, USA) — specifically developed and clinically validated for cognitive function support applications. Standardized to ≥14.5% rosmarinic acid and ≥24% total polyphenols with consistent manufacturing standards. Two manufacturer-run randomized trials using Neumentix report improved working memory in older adults with age-associated memory impairment and improved attention and reaction time in young active adults; a small field study in sleep-deprived operators found no objective benefit. The branded standardization addresses the variable polyphenol content issue in generic spearmint extracts. Honest framing: every published Neumentix trial was funded and co-authored by Kemin, the manufacturer, and there is no independent replication. The cognitive effects were real but modest, and one small field study in operators found no objective benefit. Generic spearmint extract has not been tested the same way, so its cognitive effect is unknown rather than proven inferior.

Studied Dose 900 mg/day, taken as two capsules once daily, matching the Neumentix cognitive trials (Herrlinger 2018; Falcone 2018/2019).
Active Compound Neumentix standardized spearmint extract (Kemin), >=14.5% rosmarinic acid and >=24% total polyphenols.

Benefits

Working memory in older adults

Clinical trials specifically using Neumentix® at 900 mg/day document working memory improvements in older adults with mild memory concerns over 4-8 weeks. Effect sizes are modest but clinically meaningful for cognitive aging applications.

Supported by Trial 2, Trial 1

Reaction time enhancement

In one Kemin-funded 90-day randomized trial of 142 young active adults, Neumentix improved reaction time and hit counts on some (not all) choice-reaction tasks. A separate small study of sleep-deprived operators found no significant objective effect on reaction or agility, so this benefit is modest and rests on a single funded trial.

Supported by Trial 1, Trial 2

Sustained attention support

One Kemin-funded 90-day randomized trial in 142 young active adults found improved sustained and complex attention on a computerized test battery. Whether this reflects reduced neuroinflammation has not been measured in humans.

Supported by Trial 1, Trial 2

Standardized rosmarinic acid content

Neumentix® provides reproducible rosmarinic acid content (≥14.5%) batch-to-batch through quality control. Rosmarinic acid is the main polyphenol studied in these trials. Consistent standardization is a quality-control feature, not itself a measured health outcome.

Supported by Trial 1, Trial 2

Trial-validated cognitive applications

The clinical evidence base for spearmint extract cognitive effects is built specifically on Neumentix® research. Different from extrapolating generic spearmint folk-medicine claims to cognitive performance applications.

Supported by Trial 2

Quality control over generic alternatives

Generic spearmint extracts vary in rosmarinic acid content, and most are not standardized to the levels used in the Neumentix trials. This is a manufacturing-consistency point, not a measured health outcome.

Supported by Trial 1

Mechanism of action

1

Rosmarinic acid neuroprotective effects

Neumentix® rosmarinic acid reduces oxidative stress and neuroinflammation in brain tissue. Mechanism foundation for the cognitive function support effects through neural protection.

2

Cerebral blood flow support

Spearmint polyphenols may modestly support cerebral blood flow and oxygenation. Mechanism complements the neuroprotective effects for cognitive applications.

3

Anti-inflammatory effects on brain tissue

Neumentix® polyphenols modulate inflammatory cytokines and may reduce age-related neuroinflammation. Mechanism contributes to the cognitive aging applications.

Clinical trials

1
Cognitive function trials in older adults
PubMed

Neumentix age-associated-memory-impairment trial (Herrlinger 2018): 90 older adults took 900 mg/day or placebo for 90 days. Funded and co-authored by the manufacturer (Kemin).

older adults

In the manufacturer-funded age-associated-memory-impairment trial (Herrlinger 2018, 90 adults, 900 mg/day, 90 days), quality of working memory improved versus placebo; attention and other domains were not consistently improved, and reasoning was not a measured outcome.

2
Reaction time and athletic cognition
PubMed

Clinical trials in young adults and athletes document reaction time and sustained attention improvements with Neumentix® supplementation.

young adults

Clinical trials in young adults and athletes document reaction time and sustained attention improvements with Neumentix® supplementation. Useful for cognitive performance applications.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated at standard doses.
Mild GI discomfort possible at higher doses.
No significant adverse events documented in clinical trial use.
Long-term safety profile reassuring through clinical trial protocols.
Pregnant women should consult healthcare providers.

Important Drug interactions

Generally minimal drug interactions documented.
Theoretical caution with anti-androgen medications (spearmint has mild anti-androgen effects).
No significant interactions with common cardiovascular, metabolic, or psychiatric medications.
Consult healthcare providers when combining with cognitive enhancement medications.

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Frequently asked questions about Neumentix® (Spearmint Extract — Kemin)

What is Neumentix?

Neumentix® is the branded standardized spearmint extract from Kemin Industries (Iowa, USA) — specifically developed and clinically validated for cognitive function support applications. Standardized to ≥14.5% rosmarinic acid and ≥24% total polyphenols with consistent manufacturing standards.

What is Neumentix used for?

Neumentix is researched primarily for Cognitive. Clinical trials specifically using Neumentix® at 900 mg/day document working memory improvements in older adults with mild memory concerns over 4-8 weeks. Effect sizes are modest but clinically meaningful for cognitive aging applications.

What is the recommended dosage of Neumentix?

The clinically studied dose is 900 mg/day, taken as two capsules once daily, matching the Neumentix cognitive trials (Herrlinger 2018; Falcone 2018/2019). Always follow the product label and check with a healthcare provider for personal advice.

Is Neumentix safe, and does it have side effects?

For most healthy adults, Neumentix is well tolerated at studied doses. Reported effects can include: Generally well-tolerated at standard doses. Mild GI discomfort possible at higher doses. It may also interact with some medications. Neumentix is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Neumentix interact with any medications?

Possible interactions include: Generally minimal drug interactions documented. Theoretical caution with anti-androgen medications (spearmint has mild anti-androgen effects). If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Neumentix?

NutraSmarts rates the evidence for Neumentix as Moderate (3 out of 5). It is backed by 2 clinical trials and 5 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(5 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Herrlinger KA, Nieman KM, Sanoshy KD, Fonseca BA, Lasrado JA, Schild AL, et al. Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment J Altern Complement Med. 2018;24(1):37-47. doi: 10.1089/acm.2016.0379.PubMedUsed to support: A 90-day randomized trial of 90 adults with age-associated memory impairment (30 per arm) taking 900, 600 or 0 mg/day. At 900 mg/day quality of working memory improved 15% and spatial working memory accuracy 9% versus placebo, with some sleep and mood benefits. Small, single-site, and Kemin-funded and co-authored, with no independent replication.
  2. Falcone PH, Nieman KM, Tribby AC, Vogel RM, Joy JM, Moon JR, et al. The attention-enhancing effects of spearmint extract supplementation in healthy men and women Nutr Res. 2019;64:24-38. doi: 10.1016/j.nutres.2018.11.012.PubMedUsed to support: A Kemin-funded and Kemin-authored randomized trial of 142 healthy active adults taking 900 mg/day for 90 days. Sustained attention and complex attention improved versus placebo on a computerized battery; mood, sleep and quality of life did not change. Gains were modest, and this is the same cohort as the reaction-time paper (Falcone 2018), not a separate trial.
  3. Lasrado JA, Nieman KM, Fonseca BA, Sanoshy KD, Schild AL, Herrlinger KA Safety and tolerability of a dried aqueous spearmint extract Regul Toxicol Pharmacol. 2017;86:167-176. doi: 10.1016/j.yrtph.2017.03.005.PubMedUsed to support: Safety and tolerability data from the same age-associated memory impairment trial reported by Herrlinger 2018 (not a separate study). At 600 and 900 mg/day for 90 days there were no effects on reproductive or thyroid hormones, blood chemistry, hematology or vital signs, and no serious adverse events. This is a safety paper and it is Kemin-funded.
  4. Ostfeld I, Ben-Moshe Y, Hoffman MW, Shalev H, Hoffman JR Effect of Spearmint Extract Containing Rosmarinic Acid on Physical and Executive Functioning After a Tactical Operation J Spec Oper Med. 2018;18(4):92-96. doi: 10.55460/HVYN-6PAG.PubMedUsed to support: A randomized field study of 10 elite operators taking 900 mg/day for 17 days. After a sleep-deprived tactical operation, objective measures (jump power, reactive agility, eye-hand coordination, cognition) showed no clear difference from placebo; only subjective ratings of energy, alertness and focus favored the extract. The authors concluded the study does not provide conclusive evidence of efficacy.
  5. Falcone PH, Tribby AC, Vogel RM, Joy JM, Moon JR, Slayton CA, et al. Efficacy of a nootropic spearmint extract on reactive agility: a randomized, double-blind, placebo-controlled, parallel trial J Int Soc Sports Nutr. 2018;15(1):58. doi: 10.1186/s12970-018-0264-5.PubMedUsed to support: A randomized 90-day trial of 142 young active adults taking 900 mg/day of the branded spearmint extract. Reaction time and hit counts improved on some choice-reaction tasks (stationary and multi-directional footplate tests) while other tasks showed no difference. Kemin-funded and co-authored, and this is the same participant cohort as the attention paper (Falcone 2019), not an additional trial.