Benefits
Traditional use to increase urine flow
The European Medicines Agency accepts lovage root tea as a traditional herbal medicine to increase the amount of urine and flush the urinary tract as an add-on in minor urinary complaints, based only on long-standing use. Its review found no published clinical studies of lovage root alone, and a 2021 periodic review found nothing that changed this.
Urinary tract findings for a lovage, centaury and rosemary blend
In a double-blind trial of 659 women with acute bladder infection, tablets with 18 mg each of lovage root, centaury and rosemary for 7 days left 83.5% needing no further antibiotics versus 89.8% after one antibiotic dose, within the preset margin, while 5 women versus 1 developed kidney infection. The maker sponsored it; lovage's share cannot be separated.
Pooled studies of the three-herb blend compared with antibiotics
A 2026 review pooled 12 studies (3,821 patients; eight randomized) of the lovage, centaury and rosemary blend in people with or at risk of urinary infections, mostly compared with antibiotics. It reported similar symptom relief, similar overall adverse events and fewer digestive side effects with the blend, but study designs varied widely. None tested lovage on its own.
Inflammatory pain in rat bladder models of the three-herb blend
Given by mouth, the powdered lovage, centaury and rosemary mixture in Canephron N reduced inflammation and pain sensitivity in rats with chemically induced bladder inflammation, and pain sensitivity in a rat prostate model. Its individual components also reduced pain sensitivity. The maker co-authored the work, and it has not been shown in people.
Bacterial growth and drug-pump activity in lab tests
In a lab screen for blockers of bacterial drug pumps, a lovage extract was the most active of 84 plant extracts at boosting the antibiotic ciprofloxacin against Salmonella, though its purified compounds did not reproduce this. Root polyacetylenes also slowed mycobacteria. None of this has been tested in people taking the root.
Historical use for appetite, bloating and gas
Older European herbals describe lovage root as a carminative and stomach herb, sometimes taken as a tea half an hour before meals, and Czech multi-herb teas containing it are authorized for poor appetite, bloating and gas. The EU monograph does not accept this use for lovage on its own, and no human study has measured it.
Mechanism of action
Urine volume in older animal experiments
Older experiments in rabbits and mice found that a lovage root infusion slightly raised urine volume and chloride, but other tests of the crude root found no diuretic effect. No human study has measured urine output, and herbal handbooks stress that plenty of fluid is needed for this kind of flushing.
Phthalides relax smooth muscle in isolated tissue
Ligustilide and butylidenephthalide, the main compounds of the volatile oil, relaxed isolated guinea pig gut muscle and rat blood vessel and uterine tissue in lab tests, apparently by limiting calcium entry into muscle cells. In rats only about 2.6% of an oral ligustilide dose was absorbed, and no human data exist.
Furanocoumarins react with ultraviolet light
Lovage root contains furanocoumarins such as xanthotoxin, psoralen and bergapten, compounds that become reactive in ultraviolet light and have been linked to gene damage in lab tests. Dried commercial roots held 15 to 24 mg of the four main coumarins per gram, but how much reaches a tea, the blood or the skin has not been measured.
Clinical trials
Double-blind, double-dummy, randomized, multicenter non-inferiority trial of Canephron N (BNO 1045) coated tablets with 18 mg each of powdered centaury herb, lovage root and rosemary leaf, 2 tablets 3 times daily for 7 days, versus a single dose of fosfomycin trometamol; sponsored by Bionorica SE, the blend's maker, which employs three of the five authors (Wagenlehner et al. 2018, Urol Int)
659 women aged 18 to 70 with newly diagnosed acute lower uncomplicated urinary tract infection (325 blend, 334 fosfomycin).
Between days 1 and 38, 83.5% on the blend and 89.8% on fosfomycin needed no additional antibiotics, a difference of 6.26 points that met the 15% non-inferiority margin. Pyelonephritis occurred in 5 women on the blend and 1 on fosfomycin, and digestive events were more common with fosfomycin. A three-herb blend, so nothing can be credited to lovage alone.
Randomized comparison (1:1) of Canephron N oral solution (lovage root, centaury herb and rosemary leaf), 5 mL three times daily for 3 weeks, versus ciprofloxacin 500 mg three times daily for 3 days after midurethral sling surgery; two authors report speaker fees from Bionorica, the blend's maker (Rechberger et al. 2020, J Clin Med)
562 women having midurethral sling surgery for stress urinary incontinence.
Within 6 months, a urinary tract infection occurred in 36 women (13.64%) on the blend and 29 (10.98%) on ciprofloxacin, with no statistically significant difference. There was no placebo group, and the blend's effect cannot be assigned to lovage.
Systematic review and random-effects meta-analysis of Canephron N (lovage root, centaury herb and rosemary leaf) in urinary tract infection studies, searching to July 2025, with Cochrane RoB 2 and ROBINS-I risk-of-bias tools (Ak et al. 2026, Neurourol Urodyn)
12 studies (eight randomized trials, three observational and one retrospective) with 3,821 patients, mostly comparing the blend with antibiotics.
The authors judged the blend non-inferior to antibiotics for recurrence (6-month rates 8.9% versus 17.8%) and symptom scores, and reported a significant pooled difference in bacteriuria clearance (RR 1.34, 95% CI 1.20 to 1.48) with heterogeneity of 72%. Overall adverse events did not differ (RR 0.90), with fewer digestive events on the blend (4.8% versus 7.1%). Designs and comparators varied, and no study tested lovage alone.
Open comparative study: Canephron N (lovage root, rosemary leaves and centaury herb) for 6 months added to standard diabetes treatment and an ACE inhibitor, versus standard treatment and ACE inhibitor alone (Martynyuk et al. 2014, J Altern Complement Med)
59 patients with diabetes and diabetic nephropathy.
After 6 months, urine albumin (microalbuminuria) fell significantly more in the blend group than in controls, markers of antioxidant defense and lipid peroxidation improved, and liver enzymes did not change. Open label, small and a three-herb blend, so it says nothing about lovage alone.