Home Ingredients Kinetiq® (Bitter Orange Extract — Novel Ingredients)
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Kinetiq® (Bitter Orange Extract — Novel Ingredients)

Citrus aurantium
Evidence Level
Limited
0 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

Kinetiq® is a patented bitter orange (Citrus aurantium) extract standardized for p-synephrine, used as a non-stimulant thermogenic for weight management and energy. Unlike caffeine or the banned ephedra, p-synephrine is designed to support fat metabolism without jitters. The supplier reports a series of human safety and efficacy trials.

Studied Dose Commonly providing around 50 mg of p-synephrine per day.
Active Compound Bitter orange (Citrus aurantium) extract standardized for p-synephrine.

Benefits

Thermogenesis and weight management

Bitter orange p-synephrine is studied for supporting thermogenesis and fat metabolism, aiding weight management alongside diet and exercise.

Energy and alertness

Kinetiq is positioned to support energy and alertness without the jitters of stimulants such as caffeine or ephedra.

Exercise performance

Recent research explores p-synephrine for supporting resistance-training performance.

Mechanism of action

1

Beta-3 adrenergic action

p-Synephrine binds beta-3 adrenergic receptors, supporting the breakdown of fat for energy without strongly stimulating the heart.

2

Non-stimulant metabolism

Kinetiq is designed to raise metabolic rate modestly without the cardiovascular stimulation of ephedra-type compounds.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated at recommended doses.
May cause mild increases in heart rate or blood pressure in sensitive people.
Avoid combining with high-dose stimulants.

Important Drug interactions

Stimulant medications — possible additive effects; use caution.
MAO inhibitors — avoid combining with bitter orange.
Tell your doctor if you have heart disease, high blood pressure, or take medication.

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Frequently asked questions about Kinetiq® (Bitter Orange Extract — Novel Ingredients)

What is Kinetiq?

Kinetiq® is a patented bitter orange (Citrus aurantium) extract standardized for p-synephrine, used as a non-stimulant thermogenic for weight management and energy. Unlike caffeine or the banned ephedra, p-synephrine is designed to support fat metabolism without jitters.

What is Kinetiq used for?

Kinetiq is researched primarily for Weight Management, Energy, and Athletic Performance. Bitter orange p-synephrine is studied for supporting thermogenesis and fat metabolism, aiding weight management alongside diet and exercise.

What is the recommended dosage of Kinetiq?

The clinically studied dose is Commonly providing around 50 mg of p-synephrine per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Kinetiq safe, and does it have side effects?

For most healthy adults, Kinetiq is well tolerated at studied doses. Reported effects can include: Generally well-tolerated at recommended doses. May cause mild increases in heart rate or blood pressure in sensitive people. It may also interact with some medications. Kinetiq is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Kinetiq interact with any medications?

Possible interactions include: Stimulant medications — possible additive effects; use caution. MAO inhibitors — avoid combining with bitter orange. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Kinetiq?

NutraSmarts rates the evidence for Kinetiq as Limited (2 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Stohs SJ, Preuss HG, Shara M A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine Int J Med Sci. 2012;9(7):527-538. doi:10.7150/ijms.4446.PubMedUsed to support: Review of over 20 human clinical studies (~360 subjects) showing that bitter orange extract / p-synephrine did not produce significant adverse cardiovascular events and was associated with modest increases in resting metabolic rate and modest weight loss; supports Thermogenesis and weight management and Energy and alertness benefits of Kinetiq® — evidence is for p-synephrine as an active, not the Kinetiq® brand specifically
  2. Gutiérrez-Hellín J, Del Coso J Acute p-synephrine ingestion increases fat oxidation rate during exercise Br J Clin Pharmacol. 2016;82(2):362-368. doi:10.1111/bcp.12952.PubMedUsed to support: Placebo-controlled crossover trial demonstrating that acute p-synephrine ingestion significantly increased maximal fat oxidation rate during exercise while reducing carbohydrate utilization; supports Thermogenesis and weight management and Exercise performance benefits of Kinetiq® — evidence is for p-synephrine as an active compound, not the Kinetiq® brand specifically
  3. Ruiz-Moreno C, Del Coso J, Giráldez-Costas V, González-García J, Gutiérrez-Hellín J Effects of p-Synephrine during Exercise: A Brief Narrative Review Nutrients. 2021;13(1):233. doi:10.3390/nu13010233.PubMedUsed to support: Narrative review confirming that p-synephrine at 2–3 mg/kg enhances fat oxidation during exercise and does not increase heart rate or adverse events; supports Exercise performance and Thermogenesis and weight management benefits of Kinetiq® — evidence is for p-synephrine as an active, not the Kinetiq® brand specifically