i-Sabi® (Wasabi Extract — 6-MSITC)

i-Sabi® is a standardized wasabi (Eutrema japonicum) extract delivering 6-MSITC, the bioactive isothiocyanate behind wasabi's pungency. Beyond its culinary kick, 6-MSITC is studied for brain health, and a randomized controlled trial found wasabi extract improved memory in healthy older adults.

i-Sabi is researched primarily for Cognitive. In a double-blind randomized controlled trial, wasabi extract with 6-MSITC improved memory functioning in healthy adults aged 60 and older.

The clinically studied dose is About 0.8 mg of 6-MSITC (around 100 mg of wasabi extract) per day. Always follow the product label and check with a healthcare provider for personal advice.

For most healthy adults, i-Sabi is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. It may also interact with some medications. i-Sabi is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Possible interactions include: No major drug interactions are established for this ingredient. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

NutraSmarts rates the evidence for i-Sabi as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.