Home Ingredients Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)
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Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)

Ginkgo biloba
Evidence Level
Strong
2 Clinical Trials
6 Documented Benefits
4/5 Evidence Score

Ginkgoselect® Phytosome is a Ginkgo biloba extract phytosome® developed by Indena (Italy) — using Phytosome® technology applied to standardized ginkgo biloba leaf extract. Distinguished by enhanced bioavailability of ginkgo flavonoids and terpenoids, plus pharmaceutical-grade quality. Used for: cognitive function, microcirculation (especially cerebral), peripheral circulation, age-related cognitive support.

Studied Dose 120-240 mg/day Ginkgoselect Phytosome
Active Compound Ginkgo flavonoids (24%) and terpene lactones (6%) Phytosome®

Benefits

Cognitive Function and Working Memory

Ginkgo biloba has long history of use for cognitive function; Phytosome bioavailability advantage delivers more active to brain.

Supported by Trial 1, Trial 2

Cerebral Microcirculation

Improves cerebral blood flow and microcirculation — foundation for cognitive applications.

Supported by Trial 1

Peripheral Circulation

Supports peripheral circulation; useful for: cold extremities, claudication adjunct.

Age-Related Cognitive Support

Useful component of healthy aging cognitive support; some evidence for mild cognitive impairment.

Supported by Trial 1

Antioxidant Activity

Flavonoids provide antioxidant protection.

Enhanced Bioavailability vs Standard Ginkgo

Phytosome technology improves ginkgo bioactive absorption.

Supported by Trial 2

Mechanism of action

1

Ginkgo Flavonoids and Terpene Lactones

Active compounds: flavonoids (quercetin glycosides, kaempferol) — antioxidants; terpene lactones (ginkgolides A, B, C, J, bilobalide) — unique to ginkgo, modulate platelet activating factor (PAF) and provide neuroprotection.

2

Cerebral Blood Flow Enhancement

Increases cerebral microcirculation — supports cognitive function via improved brain perfusion.

3

Platelet-Activating Factor (PAF) Antagonism

Ginkgolides antagonize PAF — modest antiplatelet effect; relevant to vascular benefits but also bleeding risk.

4

Antioxidant Protection

Ginkgo flavonoids reduce oxidative stress in brain tissue.

5

Phytosome® Bioavailability

Enhanced absorption of ginkgo bioactives via Phytosome complex.

Clinical trials

1
Ginkgo Biloba for Cognitive Function — General Evidence
PubMed

Multiple ginkgo RCTs for cognitive function across populations.

Various populations including older adults and mild cognitive impairment.

Modest cognitive benefits; effect size variable; bioavailable forms more reliable.

2
Ginkgoselect Phytosome Specific Studies — Indena
PubMed

Indena studies of Ginkgoselect Phytosome bioavailability and clinical effects.

Adults across applications.

Enhanced bioavailability and clinical effects.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Headache rare.
Bleeding risk — ginkgo's antiplatelet effect from PAF antagonism is significant; theoretical risk.
Allergic reactions rare.
Soy allergy considerations (Phytosome).

Important Drug interactions

Anticoagulants — significant antiplatelet effect; theoretical bleeding risk; consult prescriber; relevance for warfarin, aspirin, clopidogrel.
MAOIs — theoretical interactions.
SSRIs — theoretical interactions.
Diabetes medications — modest hypoglycemic effects.
Pregnancy — ginkgo contraindicated in pregnancy due to bleeding concerns; avoid supplementation.
Lactation — limited safety data; avoid.
Pre-surgery — discontinue 2-3 weeks before due to bleeding risk (longer than other supplements).
Anti-seizure medications — theoretical interactions; ginkgo may affect seizure threshold; avoid with seizure disorders.

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Frequently asked questions about Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)

What is Ginkgoselect Phytosome?

Ginkgoselect® Phytosome is a Ginkgo biloba extract phytosome® developed by Indena (Italy) — using Phytosome® technology applied to standardized ginkgo biloba leaf extract. Distinguished by enhanced bioavailability of ginkgo flavonoids and terpenoids, plus pharmaceutical-grade quality.

What is Ginkgoselect Phytosome used for?

Ginkgoselect Phytosome is researched primarily for Cognitive and Cardiovascular. Ginkgo biloba has long history of use for cognitive function; Phytosome bioavailability advantage delivers more active to brain.

What is the recommended dosage of Ginkgoselect Phytosome?

The clinically studied dose is 120-240 mg/day Ginkgoselect Phytosome Always follow the product label and check with a healthcare provider for personal advice.

Is Ginkgoselect Phytosome safe, and does it have side effects?

For most healthy adults, Ginkgoselect Phytosome is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild GI distress. It may also interact with some medications. Ginkgoselect Phytosome is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Ginkgoselect Phytosome interact with any medications?

Possible interactions include: Anticoagulants — significant antiplatelet effect; theoretical bleeding risk; consult prescriber; relevance for warfarin, aspirin, clopidogrel. MAOIs — theoretical interactions. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Ginkgoselect Phytosome?

NutraSmarts rates the evidence for Ginkgoselect Phytosome as Strong (4 out of 5). It is backed by 2 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Mauri P, Simonetti P, Gardana C, Minoggio M, Morazzoni P, Bombardelli E, Pietta P Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts Rapid Commun Mass Spectrom. 2001;15(12):929-934. doi: 10.1002/rcm.316.PubMedUsed to support: Backs the bioavailability advantage of Ginkgoselect Phytosome: in human volunteers the phospholipid-complex (Ginkgoselect Phytosome) produced higher plasma terpene lactone levels than the free Ginkgoselect extract. Small Indena (Morazzoni/Bombardelli/Pietta) PK study; the bioavailability claim is the best-supported one for this ingredient.
  2. Bonassi S, Prinzi G, Lamonaca P, Russo P, Paximadas I, Rasoni G, Rossi R, Ruggi M, Malandrino S, Sanchez-Flores M, Valdiglesias V, Benassi B, Pacchierotti F, Villani P, et al. Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx] BMC Complement Altern Med. 2018;18(1):22. doi: 10.1186/s12906-018-2080-5.PubMedUsed to support: Backs the safety (clinical and genomic) of the branded Ginkgoselect Plus (IDN 5933) extract in elderly subjects. Randomized placebo-controlled trial focused on safety/genotoxicity endpoints rather than proving a cognition benefit; phytosome-specific human data overall remain limited.
  3. Naik SR, Pilgaonkar VW, Panda VS Neuropharmacological evaluation of Ginkgo biloba phytosomes in rodents Phytother Res. 2006;20(10):901-905. doi: 10.1002/ptr.1973.PubMedUsed to support: Backs a cognition/CNS rationale for Ginkgo biloba phytosome. Honesty: preclinical (rodent) study only; ginkgo's human cognition evidence is weak overall and phytosome-specific human cognitive data are limited.
  4. Naik SR, Pilgaonkar VW, Panda VS Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain Phytother Res. 2006;20(11):1013-1016. doi: 10.1002/ptr.1976.PubMedUsed to support: Backs an antioxidant/neuroprotective rationale for Ginkgo biloba phytosome. Preclinical rat-brain study only; mechanistic support, not clinical proof of cognition/circulation benefit.