Home Ingredients Fruitflow® (Water-Soluble Tomato Extract — DSM)
Cardiovascular

Fruitflow® (Water-Soluble Tomato Extract — DSM)

Solanum lycopersicum
Evidence Level
Strong
2 Clinical Trials
3 Documented Benefits
4/5 Evidence Score

Fruitflow® is a water-soluble concentrate made from the clear jelly around tomato seeds, developed to support healthy blood flow by gently reducing the tendency of platelets to clump together. It is one of the few supplement ingredients to hold an authorised European health claim for helping maintain normal platelet aggregation, and its effect has been demonstrated in randomized human trials.

Studied Dose ~150 mg/day (one serving).
Active Compound Water-soluble blend of tomato compounds (nucleosides, phenolic acids, flavonoids) standardized from tomato serum.

Benefits

Healthy platelet function

Fruitflow reduces the tendency of blood platelets to aggregate, supporting smooth blood flow. This benefit is recognized by an authorised European health claim for maintaining normal platelet aggregation.

Supported by Trial 1, Trial 2

Blood flow and circulation

By keeping platelets less sticky, the extract supports healthy circulation, a gentler approach than aspirin for people seeking blood-flow support without affecting the stomach lining.

Supported by Trial 1

Fast and lasting effect

A single daily serving produces a measurable anti-aggregation effect within hours that persists across the day, as shown in controlled human studies.

Supported by Trial 2

Mechanism of action

1

Platelet aggregation inhibition

The tomato compounds interfere with the signaling that makes platelets clump, lowering aggregation without the irreversible COX inhibition of aspirin.

2

Smooth muscle and flow support

Reduced platelet activation supports healthy endothelial function and blood flow in the vessels.

Clinical trials

1
Tomato Extract and Platelet Function — RCT
PubMed

Randomized controlled trial of the water-soluble tomato extract on platelet aggregation compared with aspirin. (O'Kennedy et al. 2017, European Journal of Clinical Nutrition)

Healthy adults.

The tomato extract significantly reduced platelet aggregation versus control, supporting its anti-platelet and blood-flow benefit with a favorable tolerability profile.

2
Antiplatelet Components of Tomato — Human Study
PubMed

Double-blind, placebo-controlled cannulation study of the antiplatelet components of tomato extract in healthy humans. (O'Kennedy et al. 2006, American Journal of Clinical Nutrition)

Healthy adults.

A single dose reduced ex vivo platelet aggregation within about 3 hours, with the effect sustained, establishing the time course of the benefit.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — unlike aspirin, it does not irritate the stomach lining.
Mild digestive upset is uncommon.
People with tomato allergy should avoid it.

Important Drug interactions

Anticoagulant and antiplatelet drugs — additive effect on bleeding; use only with medical guidance.
Aspirin and NSAIDs — possible additive anti-platelet effect.
Stop before surgery and tell your doctor if you take blood thinners.

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Frequently asked questions about Fruitflow® (Water-Soluble Tomato Extract — DSM)

What is Fruitflow?

Fruitflow® is a water-soluble concentrate made from the clear jelly around tomato seeds, developed to support healthy blood flow by gently reducing the tendency of platelets to clump together.

What is Fruitflow used for?

Fruitflow is researched primarily for Cardiovascular. Fruitflow reduces the tendency of blood platelets to aggregate, supporting smooth blood flow. This benefit is recognized by an authorised European health claim for maintaining normal platelet aggregation.

What is the recommended dosage of Fruitflow?

The clinically studied dose is ~150 mg/day (one serving). Always follow the product label and check with a healthcare provider for personal advice.

Is Fruitflow safe, and does it have side effects?

For most healthy adults, Fruitflow is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — unlike aspirin, it does not irritate the stomach lining. Mild digestive upset is uncommon. It may also interact with some medications. Fruitflow is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Fruitflow interact with any medications?

Possible interactions include: Anticoagulant and antiplatelet drugs — additive effect on bleeding; use only with medical guidance. Aspirin and NSAIDs — possible additive anti-platelet effect. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Fruitflow?

NutraSmarts rates the evidence for Fruitflow as Strong (4 out of 5). It is backed by 2 clinical trials and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. O'Kennedy N, Crosbie L, Whelan S, et al. A randomised controlled trial comparing a dietary antiplatelet, the water-soluble tomato extract Fruitflow, with 75 mg aspirin in healthy subjects. Eur J Clin Nutr. 2017;71(6):723-730..PubMedUsed to support: RCT showing anti-platelet effect of the tomato extract.
  2. O'Kennedy N, Crosbie L, van Lieshout M, et al. Effects of antiplatelet components of tomato extract on platelet function in vitro and ex vivo: a time-course cannulation study in healthy humans. Am J Clin Nutr. 2006;84(3):570-9..PubMedUsed to support: Human study establishing the time course of the platelet effect.