Home Ingredients EyeMuse® (Postbiotic L. paracasei KW3110 for Eye Fatigue)
Eye Health

EyeMuse® (Postbiotic L. paracasei KW3110 for Eye Fatigue)

Lacticaseibacillus paracasei KW3110
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

EyeMuse is a postbiotic ingredient made of heat-killed Lacticaseibacillus paracasei KW3110, developed by Kirin and marketed for screen-related eye fatigue. It contains no lutein or zeaxanthin. Its proposed action is immune-modulating and anti-inflammatory rather than that of a carotenoid pigment.

Studied Dose About 50 mg of heat-killed KW3110 postbiotic daily, the amount used in the 8-week eye-fatigue trials.
Active Compound Heat-killed (paraprobiotic) Lacticaseibacillus paracasei KW3110, a postbiotic developed by Kirin and supplied as EyeMuse. It contains no lutein or zeaxanthin.

Benefits

Screen-related eye fatigue

Heat-killed KW3110 taken daily for 8 weeks was tested in small trials for eye fatigue brought on by prolonged screen (visual display terminal) use.

Supported by Trial 1

Eye comfort during screen use

The trials measured critical flicker frequency, a marker of eye fatigue. Effects were modest, and for the primary endpoint of one trial the benefit appeared only in a subgroup with high baseline fatigue.

Supported by Trial 1

How it is thought to work

KW3110 acts as an immune-modulating, anti-inflammatory postbiotic and raises regulatory signals such as interleukin-10 in laboratory models. These are mechanisms, not measured clinical outcomes, and no skin benefit has been tested in people.

Supported by Trial 1

Mechanism of action

1

Immune modulation

KW3110 stimulates immune cells to release regulatory cytokines such as interleukin-10, which may temper inflammatory stress in retinal cells exposed to blue light in laboratory models.

2

Anti-inflammatory action

By dampening inflammatory signaling, the postbiotic is proposed to reduce blue-light-driven stress on retinal pigment epithelium cells; this is shown in cell and animal models, not as a clinical outcome in people.

Clinical trials

1
KW3110 Postbiotic and Screen-Related Eye Fatigue: RCT
PubMed

Randomized, double-blind, placebo-controlled trial of heat-killed L. paracasei KW3110 on eye fatigue from visual display terminal (screen) use over 8 weeks. (Morita et al. 2018, Nutrients)

62 healthy Japanese adults aged 35 to 45 with screen-related eye fatigue.

Critical flicker frequency, a marker of eye fatigue, tended to decline less in the KW3110 group; the difference reached significance only in a subgroup with high baseline eye fatigue at week 4. The manufacturer, Kirin, funded the study.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — adverse effects are uncommon.
No product-specific safety concerns were reported in the 8-week trials.
Mild digestive upset is occasionally reported.

Important Drug interactions

No major drug interactions are established.
Generally compatible with medications.
Tell your doctor if pregnant, breastfeeding, or managing a condition.

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Frequently asked questions about EyeMuse® (Postbiotic L. paracasei KW3110 for Eye Fatigue)

What is EyeMuse?

EyeMuse is a postbiotic ingredient made of heat-killed Lacticaseibacillus paracasei KW3110, developed by Kirin and marketed for screen-related eye fatigue. It contains no lutein or zeaxanthin. Its proposed action is immune-modulating and anti-inflammatory rather than that of a carotenoid pigment.

What is EyeMuse used for?

EyeMuse is researched primarily for Eye Health. Heat-killed KW3110 taken daily for 8 weeks was tested in small trials for eye fatigue brought on by prolonged screen (visual display terminal) use.

What is the recommended dosage of EyeMuse?

The clinically studied dose is About 50 mg of heat-killed KW3110 postbiotic daily, the amount used in the 8-week eye-fatigue trials. Always follow the product label and check with a healthcare provider for personal advice.

Is EyeMuse safe, and does it have side effects?

For most healthy adults, EyeMuse is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon. No product-specific safety concerns were reported in the 8-week trials. It may also interact with some medications. EyeMuse is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does EyeMuse interact with any medications?

Possible interactions include: No major drug interactions are established. Generally compatible with medications. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for EyeMuse?

NutraSmarts rates the evidence for EyeMuse as Limited (2 out of 5). It is backed by 1 clinical trial and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Morita Y, Jounai K, Miyake M, Inaba M, Kanauchi O. Effect of Heat-Killed Lactobacillus paracasei KW3110 Ingestion on Ocular Disorders Caused by Visual Display Terminal (VDT) Loads: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study. Nutrients. 2018;10(8):1058. doi: 10.3390/nu10081058.PubMedUsed to support: In 62 adults with screen-related eye fatigue, 8 weeks of heat-killed L. paracasei KW3110 (the EyeMuse strain) did not significantly beat placebo on the primary eye-fatigue measure overall; a benefit reached significance only in a subgroup with high baseline fatigue at week 4. Kirin, which sells the strain, funded the study.
  2. Yamazaki T, Suzuki H, Yamada S, Ohshio K, Sugamata M, Yamada T, Morita Y. Lactobacillus paracasei KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans. Int J Mol Sci. 2020;21(14):5091. doi: 10.3390/ijms21145091.PubMedUsed to support: In 88 healthy adults, 8 weeks of KW3110 gave a larger improvement than placebo in critical flicker frequency, a surrogate marker of eye fatigue, at weeks 4 and 8. All authors were employees of the manufacturer, Kirin, and the result has not been independently replicated.