EPAX® (Concentrated Omega-3 Fish Oil)

Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

EPAX is a brand of concentrated, purified fish oil from Pelagia that supplies the marine omega-3 fats EPA and DHA. The single study cited on this page did not test the EPAX brand; it compared oily fish with a general omega-3 supplement, and the only link to the brand is a disclosure that one author received equipment and supplies from Epax Norway AS. That study showed a rise in the omega-3 index, a blood marker of omega-3 status. It found no significant change in blood fats or in hs-CRP, an inflammation marker, and it did not measure anything about the brain. Broader evidence on EPA and DHA in general is covered on the omega-3 and fish oil pages and is not specific to this brand.

Studied Dose The one trial cited here used 700 mg of combined EPA and DHA per day for 8 weeks. Supplements made with EPAX oil commonly provide anywhere from a few hundred milligrams to over a gram of EPA plus DHA per serving, but those higher doses were not the ones tested in the study cited on this page.
Active Compound Concentrated marine omega-3 fatty acids (EPA and DHA) from purified fish oil, in triglyceride or ethyl-ester form.

Benefits

Heart health: what the cited study did and did not show

The study cited on this page measured blood fats and hs-CRP (an inflammation marker) in 40 young adults over 8 weeks and found no significant effect on either. What it did show was a rise in the omega-3 index, a measure of how much EPA and DHA sits in red blood cell membranes. That is a blood marker, not a heart outcome. Research on marine omega-3s and heart health in general is a separate body of work and was not tested with this brand.

Brain and mood

DHA is one of the main structural fats in the brain, which is why omega-3s are studied for thinking and mood. However, no study cited on this page measured any memory, thinking or mood outcome, so there is nothing here showing that EPAX oil affects them.

Omega-3 status

This is the one thing the cited study actually showed. In 40 adults aged 18 to 30 who ate little fish and started with a low omega-3 index, 8 weeks of 700 mg EPA plus DHA per day raised the omega-3 index by about 2%, similar to eating oily fish. Keep in mind the omega-3 index is a blood marker rather than a health outcome on its own, and this was one small, short study.

Mechanism of action

1

Membrane incorporation

EPA and DHA get built into cell membranes, and the omega-3 index measures how much of them sits in red blood cell membranes. In the cited 8 week study, omega-3 fats in red blood cells went up and omega-6 fats went down. Laboratory work suggests these fats also serve as raw material for signaling molecules involved in inflammation.

2

Anti-inflammatory resolution

In laboratory research, omega-3s are converted into signaling molecules called specialized pro-resolving mediators that appear to help wind down inflammation. That is background biology rather than a proven effect here: the only study cited on this page measured hs-CRP, a common inflammation marker, and found no significant change after 8 weeks. Joint health was not studied at all.

Clinical trials

1
Fish and Omega-3 Supplements and the Omega-3 Index (YouFish randomized trial, 2025)
PubMed

A small randomized trial in 40 adults over 8 weeks, comparing oily fish with a supplement providing 700 mg of EPA plus DHA per day. The EPAX brand was not tested or named in the study; one author disclosed receiving equipment and supplies from Epax Norway AS. (McMullan et al. 2025, Journal of Nutrition)

40 adults aged 18 to 30 who ate little fish and began the study with a low omega-3 index (below 6 percent).

Both eating oily fish and taking the supplement raised the omega-3 index by about 2%, with omega-3 fats up and omega-6 fats down in red blood cells. There were no significant effects on blood lipids or hs-CRP. No memory, thinking or mood outcomes were measured. Because the study was small and lasted 8 weeks, it shows a change in a blood marker rather than a change in health.

Side effects and drug interactions

Common Potential side effects

Purified fish oil is usually well tolerated at everyday supplement doses.
Mild fishy aftertaste, burping, or loose stools can occur; take with meals.
Choose a purified product to minimize contaminants.

Important Drug interactions

Blood thinners and antiplatelet medicines: high doses of omega-3 may add to bleeding risk, so talk to your doctor before combining them.
Blood pressure medication — possible mild additive lowering.
Tell your doctor before high doses if you have a bleeding disorder.

Frequently asked questions about EPAX® (Concentrated Omega-3 Fish Oil)

What is EPAX?

EPAX is a brand of concentrated, purified fish oil from Pelagia that supplies the marine omega-3 fats EPA and DHA. The single study cited on this page did not test the EPAX brand; it compared oily fish with a general omega-3 supplement, and the only link to the brand is a disclosure that one author received equipment a…

What is EPAX used for?

EPAX is researched primarily for Cardiovascular. The study cited on this page measured blood fats and hs-CRP (an inflammation marker) in 40 young adults over 8 weeks and found no significant effect on either.

What is the recommended dosage of EPAX?

The clinically studied dose is The one trial cited here used 700 mg of combined EPA and DHA per day for 8 weeks. Supplements made with EPAX oil commonly provide anywhere from a few hundred milligrams to over a gram of EPA plus DHA per serving, but those higher doses were not the ones tested… Always follow the product label and check with a healthcare provider for personal advice.

Is EPAX safe, and does it have side effects?

For most healthy adults, EPAX is well tolerated at studied doses. Reported effects can include: Purified fish oil is usually well tolerated at everyday supplement doses. Mild fishy aftertaste, burping, or loose stools can occur; take with meals. It may also interact with some medications. EPAX is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does EPAX interact with any medications?

Possible interactions include: Blood thinners and antiplatelet medicines: high doses of omega-3 may add to bleeding risk, so talk to your doctor before combining them. Blood pressure medication — possible mild additive lowering. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for EPAX?

NutraSmarts rates the evidence for EPAX as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. McMullan JE, Kumar RA, Yeates AJ, et al. Influence of Fish Consumption and omega-3 Supplementation on the omega-3 Index. J Nutr. 2025;155(12):4345-4355..PubMedUsed to support: Small trial (40 adults, 8 weeks) showing that 700 mg per day of EPA plus DHA raises the omega-3 index. It found no significant change in blood fats or hs-CRP, measured no cognitive outcomes, and did not test the EPAX brand.