Home Ingredients Decursinol-50® (Angelica gigas Extract)
Sleep HealthCognitive

Decursinol-50® (Angelica gigas Extract)

Angelica gigas
Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

Decursinol-50® is a Korean angelica (Angelica gigas) root extract standardized for decursin and decursinol, the compounds behind its traditional use. Angelica gigas is used in traditional Asian medicine for calm, sleep, and cognitive support. Human clinical evidence for the isolated extract is still limited.

Studied Dose Commonly around 100 to 200 mg per day.
Active Compound Angelica gigas root extract standardized for decursin and decursinol.

Benefits

Calm and sleep

Angelica gigas is traditionally used to support a calm state and restful sleep, which is the basis for Decursinol-50's positioning; this reflects traditional use rather than a dedicated human clinical trial.

Cognitive interest

Decursin and decursinol have been studied only in animal and laboratory research — memory tests in mice and protection of nerve cells in culture — for brain health and memory; human clinical data are lacking.

Limited-evidence note

Most evidence comes from traditional use and laboratory or animal studies; dedicated human clinical data are limited.

Mechanism of action

1

Neurotransmitter support

Decursin and decursinol are studied for influencing brain signaling involved in calm, sleep, and memory.

2

Antioxidant action

The decursin compounds show antioxidant activity in laboratory research.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
May cause drowsiness; use caution when driving.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Sedatives or sleep medication — possible additive calming effect; use caution.
Anticoagulants — angelica species may have a mild additive effect; monitor.
Tell your doctor if pregnant or breastfeeding.

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Frequently asked questions about Decursinol-50® (Angelica gigas Extract)

What is Decursinol-50?

Decursinol-50® is a Korean angelica (Angelica gigas) root extract standardized for decursin and decursinol, the compounds behind its traditional use. Angelica gigas is used in traditional Asian medicine for calm, sleep, and cognitive support. Human clinical evidence for the isolated extract is still limited.

What is Decursinol-50 used for?

Decursinol-50 is researched primarily for Sleep Health and Cognitive. Angelica gigas is traditionally used to support a calm state and restful sleep, which is the basis for Decursinol-50's positioning; this reflects traditional use rather than a dedicated human clinical trial.

What is the recommended dosage of Decursinol-50?

The clinically studied dose is Commonly around 100 to 200 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Decursinol-50 safe, and does it have side effects?

For most healthy adults, Decursinol-50 is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. May cause drowsiness; use caution when driving. It may also interact with some medications. Decursinol-50 is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Decursinol-50 interact with any medications?

Possible interactions include: Sedatives or sleep medication — possible additive calming effect; use caution. Anticoagulants — angelica species may have a mild additive effect; monitor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Decursinol-50?

NutraSmarts rates the evidence for Decursinol-50 as Preliminary (1 out of 5). It is backed by 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Park SJ et al. The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Aβ(1-42)-induced cognitive dysfunction in mice J Ethnopharmacol. 2012;143(2):611-20. doi:10.1016/j.jep.2012.07.019.PubMedUsed to support: Animal study demonstrating that a standardized Angelica gigas extract (INM-176) reversed scopolamine- and amyloid-beta-induced memory impairment in mice via acetylcholinesterase inhibition and neuroprotection in the hippocampus; provides mechanistic basis for cognitive interest benefit of Angelica gigas decursin/decursinol compounds (animal evidence only; human clinical data for Decursinol-50® are limited).
  2. Kang SY et al. Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity J Pharm Pharmacol. 2007;59(6):863-70. doi:10.1211/jpp.59.6.0013.PubMedUsed to support: In-vitro study demonstrating that decursinol and decursin (the active coumarins from Angelica gigas standardized in Decursinol-50®) protected primary rat cortical neurons from glutamate-induced excitotoxicity by reducing intracellular calcium and preventing glutathione depletion; provides cellular mechanistic basis for neuroprotective and cognitive interest claims (in-vitro evidence only; human clinical data are limited).