Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Cyplexinol® is a branded complex of bone morphogenetic proteins (BMPs) and collagen from ZyCal Bioceuticals, derived from bone. BMPs are signaling proteins that direct the body's bone- and cartilage-building cells, and Cyplexinol is studied for easing joint pain and supporting joint and bone health.

Studied Dose Around 150 to 300 mg per day.
Active Compound A complex of naturally sourced bone morphogenetic proteins (BMPs) with collagen and growth factors that signal bone- and cartilage-forming cells.

Benefits

Joint pain relief

In a clinical study, the bone morphogenetic protein complex supported reductions in joint pain in men and women, improving daily comfort.

Bone and cartilage support

BMPs direct stem cells to become bone- and cartilage-building cells, supporting the maintenance and repair of joint and bone tissue.

Mobility

By supporting joint structure and lowering discomfort, the complex is positioned to help with everyday movement and flexibility.

Mechanism of action

1

Bone morphogenetic protein signaling

BMPs activate the differentiation of mesenchymal stem cells into osteoblasts and chondrocytes, the cells that build bone and cartilage.

2

Collagen matrix support

The accompanying collagen and growth factors provide structural building blocks for the joint and bone matrix.

Clinical trials

1
Bone Morphogenetic Protein Complex and Joint Pain — Study
PubMed

Clinical study of the dietary supplement Cyplexinol on joint pain. (Pence et al. 2023, Journal of Clinical and Translational Research)

Men and women with joint pain.

The BMP complex supported reductions in joint pain, consistent with its bone- and cartilage-supportive signaling.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — adverse events were minimal in the study.
Mild digestive upset is occasionally reported.
Derived from bovine bone; not suitable for vegetarians.

Important Drug interactions

No significant drug interactions are established.
Generally compatible with other joint and bone supplements.
Tell your doctor if you take medication for bone or joint conditions.

Frequently asked questions about Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal)

What is Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal)?

Cyplexinol® is a branded complex of bone morphogenetic proteins (BMPs) and collagen from ZyCal Bioceuticals, derived from bone. BMPs are signaling proteins that direct the body's bone- and cartilage-building cells, and Cyplexinol is studied for easing joint pain and supporting joint and bone health.

What is the recommended dosage of Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal)?

The clinically studied dose for Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal) is Around 150 to 300 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal) used for?

Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal) is studied for joint pain relief, bone and cartilage support, mobility. In a clinical study, the bone morphogenetic protein complex supported reductions in joint pain in men and women, improving daily comfort.

Are there side effects from taking Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — adverse events were minimal in the study. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal) safe to take?

Whether Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — adverse events were minimal in the study. It may also interact with certain medications. Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Pence J, Stockton M, Bloomer RJ. The dietary supplement Cyplexinol alleviates joint pain in men and women. J Clin Transl Res. 2023;9(3):212-221..PubMedUsed to support: Clinical study supporting joint pain benefit.