Cyplexinol® (Bone Morphogenetic Protein Complex — ZyCal)

Cyplexinol® is a branded complex of bone morphogenetic proteins (BMPs) and collagen from ZyCal Bioceuticals, derived from bone. BMPs are signaling proteins involved in bone and cartilage formation, and Cyplexinol is studied for easing joint pain and supporting joint and bone health.

Cyplexinol is researched primarily for Joint Health and Bone Health. In a clinical study, the bone morphogenetic protein complex supported reductions in joint pain in men and women, improving daily comfort.

The clinically studied dose is Around 150 to 300 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

For most healthy adults, Cyplexinol is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse events were minimal in the study. Mild digestive upset is occasionally reported. It may also interact with some medications. Cyplexinol is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Possible interactions include: No significant drug interactions are established. Generally compatible with other joint and bone supplements. If you take prescription medication, check with a pharmacist or doctor before using it.

NutraSmarts rates the evidence for Cyplexinol as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.