Home Ingredients Cran-d'Or® (Cranberry Extract)
Kidney/Urinary TractWomen's HealthAntioxidant

Cran-d'Or® (Cranberry Extract)

Vaccinium macrocarpon
Evidence Level
Moderate
2 Clinical Trials
3 Documented Benefits
3/5 Evidence Score

Cran-d'Or® is a cranberry (Vaccinium macrocarpon) extract standardized for proanthocyanidins (PACs). Cranberry is the classic natural option for urinary tract health, working largely by keeping bacteria from sticking to the bladder wall.

Studied Dose Around 500 mg of cranberry concentrate per day, standardized to deliver proanthocyanidins (PACs), the fraction linked to urinary-tract benefit.
Active Compound Cranberry (Vaccinium macrocarpon) concentrate providing proanthocyanidins (PACs).

Benefits

Urinary tract health

Cranberry is widely studied for supporting urinary tract health and helping reduce the risk of recurrent urinary tract infections, recognized among non-antibiotic options.

Supported by Trial 1, Trial 2

Anti-adhesion action

Cranberry proanthocyanidins help stop certain bacteria from sticking to the bladder wall, the leading proposed mechanism.

Supported by Trial 2

Antioxidant support

Cranberry polyphenols provide antioxidant support beyond the urinary tract.

Supported by Trial 1, Trial 2

Mechanism of action

1

Type-A proanthocyanidins

Cranberry's distinctive type-A PACs interfere with the fimbriae E. coli use to adhere to the urinary lining, helping bacteria be flushed out.

2

Polyphenol antioxidants

Cranberry's broad polyphenols add antioxidant activity supporting overall health.

Clinical trials

1
Cranberry and Urinary Tract Health — Review
PubMed

Review of non-antibiotic interventions, including cranberry, to prevent recurrent urinary tract infections. (Santer et al. 2026, British Journal of General Practice)

Women (aged 16+) with recurrent UTIs.

The review supports cranberry among non-antibiotic options for helping reduce the risk of recurrent urinary tract infections.

2
Cranberry for Preventing UTIs — Cochrane Review
PubMed

Cochrane systematic review and meta-analysis of randomized trials of cranberry products for preventing urinary tract infections. (Williams et al. 2023, Cochrane Database of Systematic Reviews)

Women and children with recurrent UTIs (pooled across trials).

The meta-analysis concluded that cranberry products help reduce the risk of recurrent urinary tract infections in women and in children; benefit was less certain in elderly or catheter-using populations.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild digestive upset at high doses.
Very high intake may raise kidney-stone risk in susceptible people.

Important Drug interactions

Warfarin — cranberry may interact; monitor INR if combined.
Not a substitute for antibiotics during an active infection.
Tell your doctor about a history of kidney stones.

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Frequently asked questions about Cran-d'Or® (Cranberry Extract)

What is Cran-d'Or?

Cran-d'Or® is a cranberry (Vaccinium macrocarpon) extract standardized for proanthocyanidins (PACs). Cranberry is the classic natural option for urinary tract health, working largely by keeping bacteria from sticking to the bladder wall.

What is Cran-d'Or used for?

Cran-d'Or is researched primarily for Kidney/Urinary Tract, Women's Health, and Antioxidant. Cranberry is widely studied for supporting urinary tract health and helping reduce the risk of recurrent urinary tract infections, recognized among non-antibiotic options.

What is the recommended dosage of Cran-d'Or?

The clinically studied dose is Around 500 mg of cranberry concentrate per day, standardized to deliver proanthocyanidins (PACs), the fraction linked to urinary-tract benefit. Always follow the product label and check with a healthcare provider for personal advice.

Is Cran-d'Or safe, and does it have side effects?

For most healthy adults, Cran-d'Or is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild digestive upset at high doses. It may also interact with some medications. Cran-d'Or is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Cran-d'Or interact with any medications?

Possible interactions include: Warfarin — cranberry may interact; monitor INR if combined. Not a substitute for antibiotics during an active infection. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Cran-d'Or?

NutraSmarts rates the evidence for Cran-d'Or as Moderate (3 out of 5). It is backed by 2 clinical trials and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Santer M, Miller S, Fraser S, et al. Non-antibiotic interventions to prevent recurrent urinary tract infections in women: overview of systematic reviews of randomised controlled trials. Br J Gen Pract. 2026;(advance online publication)..PubMedUsed to support: Review supporting urinary-tract benefit of cranberry (the active in this branded cranberry).
  2. Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;4(4):CD001321. doi: 10.1002/14651858.CD001321.pub6.PubMedUsed to support: Cochrane meta-analysis concluding cranberry products help reduce the risk of recurrent UTIs in women and in children — the definitive class evidence underpinning the Moderate rating (this is generic-cranberry evidence, not a Cran-d’Or-specific trial).