Home Ingredients Cran d'Or® (Cranberry Extract — Fruit d'Or)
Kidney/Urinary TractWomen's Health

Cran d'Or® (Cranberry Extract — Fruit d'Or)

Vaccinium macrocarpon
Evidence Level
Limited
2 Clinical Trials
2 Documented Benefits
2/5 Evidence Score

Cran d'Or® is a line of cranberry (Vaccinium macrocarpon) ingredients from Fruit d'Or, sold in forms such as whole cranberry fruit powder and cranberry juice extract powder. The maker says, citing results from an outside lab it used, that 500 mg a day of its whole cranberry powder supplies 50 to 75 mg of proanthocyanidins (PACs), the compounds behind cranberry's urinary tract research. No published trial of Cran d'Or itself could be found, so the evidence on this page is for cranberry products in general. A large review of 50 trials found cranberry products were linked to fewer culture-confirmed urinary tract infections in women with repeat infections, in children and after medical procedures, but not in older people in care homes, pregnant women or people with bladder emptying problems. Cranberry is not a treatment for an active infection.

Studied Dose No dose has been tested for Cran d'Or itself. The maker says 500 mg a day of its whole cranberry powder gives about 50 to 75 mg of PACs (a maker's claim citing an outside lab). Trials of other cranberry products used many forms and doses, with no clear difference between PAC doses.
Active Compound Cranberry (Vaccinium macrocarpon) fruit powder or juice extract powder providing proanthocyanidins (PACs).

Benefits

Urinary tract health

No trial has tested Cran d'Or itself. In a review of 50 randomized trials (8,857 people) of cranberry juice, tablets and capsules, cranberry products were linked to about 30% fewer symptomatic, culture-confirmed urinary tract infections, mainly in women with repeat infections, children and people after medical procedures. Little or no difference was seen in older people in care homes or pregnant women.

Supported by Trial 2, Trial 1

Bacterial adhesion in the urinary tract

Cranberry proanthocyanidins (PACs) block P-fimbriated E. coli from attaching to the cells lining the bladder in laboratory work. This is the main proposed way cranberry works, though the review of trials found no clear difference in results between low, moderate and high PAC doses.

Supported by Trial 2, Trial 1

Mechanism of action

1

Proanthocyanidins (PACs)

Cranberry PACs inhibit the attachment of P-fimbriated E. coli to the cells that line the bladder, as described in the Cochrane review. Whether a given product delivers enough active PACs depends on how it is made and tested.

Clinical trials

1
Non-Antibiotic Options for Repeat Urinary Tract Infections (Overview of Reviews)
PubMed

Overview of 27 systematic reviews of randomized trials of non-antibiotic interventions, including 6 reviews of cranberry (Santer et al. 2026, British Journal of General Practice)

Women aged 16 or over with recurrent urinary tract infections.

Cranberry and methenamine hippurate use were supported by systematic reviews, though questions remain about dose, duration and treatment adherence. Cran d'Or was not studied.

2
Cranberry Products and Urinary Tract Infections (Cochrane Review)
PubMed

Cochrane systematic review and meta-analysis of 50 randomized or quasi-randomized trials with 8,857 participants (Williams et al. 2023, Cochrane Database of Systematic Reviews)

Women with recurrent infections, children, people after medical procedures, elderly care-home residents, pregnant women and people with bladder emptying problems.

Cranberry products lowered the risk of symptomatic, culture-confirmed infections overall (RR 0.70, moderate certainty), in women with recurrent infections (RR 0.74), children (RR 0.46) and after interventions (RR 0.47). There was little or no benefit in elderly care-home residents, pregnant women or people with bladder emptying problems, and no difference between PAC doses.

Side effects and drug interactions

Common Potential side effects

In the Cochrane review, digestive side effects were not clearly more common with cranberry than with placebo or no treatment.
Cranberry is not a treatment for an active urinary tract infection; see a doctor if you have symptoms such as burning, fever or back pain.

Important Drug interactions

Warfarin: a randomized trial of daily cranberry juice in people on warfarin found no change in warfarin levels and only a brief, small INR change, but tell your doctor and keep up your usual INR checks.
Tell your doctor about all supplements if you take prescription medication.

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Frequently asked questions about Cran d'Or® (Cranberry Extract — Fruit d'Or)

What is Cran d'Or?

Cran d'Or® is a line of cranberry (Vaccinium macrocarpon) ingredients from Fruit d'Or, sold in forms such as whole cranberry fruit powder and cranberry juice extract powder.

What is Cran d'Or used for?

Cran d'Or is researched primarily for Kidney/Urinary Tract and Women's Health. No trial has tested Cran d'Or itself. In a review of 50 randomized trials (8,857 people) of cranberry juice, tablets and capsules, cranberry products were linked to about 30% fewer symptomatic, culture-confirmed urinary tract infections, ma…

What is the recommended dosage of Cran d'Or?

No dose has been tested for Cran d'Or itself. The maker says 500 mg a day of its whole cranberry powder gives about 50 to 75 mg of PACs (a maker's claim citing an outside lab). Always follow the product label and check with a healthcare provider for personal advice.

Is Cran d'Or safe, and does it have side effects?

Side effects and cautions reported for Cran d'Or include: In the Cochrane review, digestive side effects were not clearly more common with cranberry than with placebo or no treatment. Cranberry is not a treatment for an active urinary tract infection; see a doctor if you have symptoms such as burning, fever or back pain. It may also interact with some medications. Cran d'Or is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Cran d'Or interact with any medications?

Possible interactions include: Warfarin: a randomized trial of daily cranberry juice in people on warfarin found no change in warfarin levels and only a brief, small INR change, but tell your doctor and keep up your usual INR checks. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Cran d'Or?

NutraSmarts rates the evidence for Cran d'Or as Limited (2 out of 5). It is backed by 2 study summaries and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Santer M, Miller S, Fraser S, Francis N, Lown M, Becque T, Tenters F, Hanna L, Muller I. Non-antibiotic interventions to prevent recurrent urinary tract infections in women: overview of systematic reviews of randomised controlled trials. Br J Gen Pract. 2026;Online ahead of print. doi: 10.3399/BJGP.2026.0055.PubMedUsed to support: Overview of 27 systematic reviews of non-antibiotic options for women aged 16 or over with recurrent urinary tract infections. Cranberry and methenamine hippurate were supported by systematic reviews, though questions remain about dose, duration and adherence. It covers cranberry in general, not Cran d'Or.
  2. Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;4(4):CD001321. doi: 10.1002/14651858.CD001321.pub6.PubMedUsed to support: Cochrane review of 50 trials (8,857 people). In moderate-certainty evidence, cranberry products lowered the risk of symptomatic, culture-confirmed urinary tract infections (RR 0.70), with benefit in women with recurrent infections, children and people susceptible after medical procedures, but little or no benefit in elderly care-home residents, pregnant women or people with bladder emptying problems. No difference was seen between low, moderate and high PAC doses, and digestive side effects did not clearly differ from placebo. This is evidence for cranberry products in general, not for Cran d'Or.
  3. Ansell J, McDonough M, Zhao Y, Harmatz JS, Greenblatt DJ. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol. 2009;49(7):824-30. doi: 10.1177/0091270009337510.PubMedUsed to support: Randomized, double-blind trial in 30 people on stable warfarin given 240 mL cranberry juice or placebo daily for 2 weeks. Warfarin blood levels did not change, and INR differed only on a single day, which the authors judged unlikely to matter clinically.
  4. New Hope Network. Fruit d'Or debuts unique cranberry ingredients New Hope Network industry news. 2013;Accessed October 2026..SourceUsed to support: Industry news article, not PubMed-indexed, quoting Fruit d'Or. Identifies Fruit d'Or as the maker of Cran d'Or, lists its forms (cranberry protein powder, whole fruit powder, tea powder, juice extract powder and seed oil) and quotes the company's claim, based on results from an independent accredited lab, that 500 mg a day of its whole cranberry powder enriched with skins, protein powder and seed oil supplies 50 to 75 mg of PACs.