Home Ingredients Chocamine® (Cocoa Extract — RFI)
Cardiovascular

Chocamine® (Cocoa Extract — RFI)

Theobroma cacao
Evidence Level
Preliminary
1 Clinical Trial
2 Documented Benefits
1/5 Evidence Score

Chocamine® is a cocoa (Theobroma cacao) extract from RFI Ingredients. RFI describes it as a patented, self-affirmed GRAS, water-soluble cocoa powder that gives chocolate taste without sugar, fat or dairy, lists cocoa flavanols, theobromine, amino acids, anandamides and minerals among its compounds, and suggests 500 to 1,000 mg per serving. RFI promotes it as stimulant-free support for energy and focus, but theobromine is a mild stimulant, and one retail capsule made with the Chocamine Plus version lists 40 mg caffeine, 60 mg theobromine and 25 mg total polyphenols per 500 mg. No study of Chocamine itself appears in PubMed, and none of the research cited here measured energy, focus or mood. The only cocoa study cited is a Cochrane review of flavanol-rich cocoa, which found a small short-term drop in blood pressure of about 2 mmHg.

Studied Dose RFI's supplier listing gives 500 to 1,000 mg per serving. This range comes from the supplier rather than a published trial; no study cited here tested Chocamine at any dose.
Active Compound Cocoa extract containing theobromine, some caffeine and cocoa polyphenols. RFI's supplier listing gives no standardization figure; one retail label for the Chocamine® Plus version lists 60 mg theobromine, 40 mg caffeine and 25 mg total polyphenols per 500 mg.

Benefits

Energy and focus (theobromine)

Theobromine is a mild stimulant chemically related to caffeine, and it is often described as gentler and longer lasting. That description comes from its chemistry and from product marketing, not from the research cited here: the single study on this page measured blood pressure only and did not look at energy, alertness, focus, jitteriness or crash. No Chocamine study appears in PubMed.

Supported by Trial 1

Cardiovascular support

An independent review of 35 randomized trials in 1,804 people found that cocoa products lowered blood pressure by roughly 1.76 mmHg, which the authors summarized as a small (about 2 mmHg) effect seen in the short term, on moderate-quality evidence. It tested flavanol-rich cocoa products against flavanol-free or low-flavanol controls. It did not test this branded extract, whose main marketed compound is theobromine.

Supported by Trial 1

Mechanism of action

1

Theobromine stimulation

Theobromine is a mild, long-acting relative of caffeine. This is a proposed explanation for an energy or alertness effect, not a demonstrated one, and no study cited on this page tested it.

2

Flavanol nitric-oxide support

Cocoa flavanols are thought to increase nitric-oxide signaling in blood vessels, which is the usual explanation for cocoa's small short-term effect on blood pressure. Flavanols are not the compound this extract is mainly marketed for, which is theobromine.

Clinical trials

1
Cocoa and Blood Pressure: Cochrane Review (flavanol-rich cocoa, not Chocamine)
PubMed

Cochrane systematic review of the effect of cocoa on blood pressure. (Ried et al. 2017, Cochrane Database of Systematic Reviews)

1,804 adults across 35 randomized trials of cocoa products. None of these trials used Chocamine, and none tested theobromine on its own.

Across 35 trials, blood pressure fell by about 1.76 mmHg, which the authors called a small (about 2 mmHg) short-term effect, on moderate-quality evidence. Systolic pressure fell about 4 mmHg in hypertensive participants, with no significant difference in normotensive ones (a subgroup difference of borderline significance). Longer-term effects were not established. The trials used flavanol-rich cocoa, not Chocamine, and did not isolate theobromine.

Side effects and drug interactions

Common Potential side effects

Theobromine and caffeine are stimulants; one Chocamine Plus label lists 40 mg caffeine and 60 mg theobromine per 500 mg capsule, so it can affect sleep if taken late, especially in people sensitive to caffeine.
Theobromine is toxic to dogs and cats; keep away from pets.

Important Drug interactions

Stimulant medications: possible additive effects; use caution.
Avoid taking late in the day if sensitive to stimulants.
Tell your doctor if pregnant or breastfeeding.

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Frequently asked questions about Chocamine® (Cocoa Extract — RFI)

What is Chocamine?

Chocamine® is a cocoa (Theobroma cacao) extract from RFI Ingredients. RFI describes it as a patented, self-affirmed GRAS, water-soluble cocoa powder that gives chocolate taste without sugar, fat or dairy, lists cocoa flavanols, theobromine, amino acids, anandamides and minerals among its compounds, and suggests 500 to…

What is Chocamine used for?

Chocamine is researched primarily for Cardiovascular. Theobromine is a mild stimulant chemically related to caffeine, and it is often described as gentler and longer lasting. That description comes from its chemistry and from product marketing, not from the research cited here: the single stud…

What is the recommended dosage of Chocamine?

The clinically studied dose is RFI's supplier listing gives 500 to 1,000 mg per serving. This range comes from the supplier rather than a published trial; no study cited here tested Chocamine at any dose. Always follow the product label and check with a healthcare provider for personal advice.

Is Chocamine safe, and does it have side effects?

Side effects and cautions reported for Chocamine include: Theobromine and caffeine are stimulants; one Chocamine Plus label lists 40 mg caffeine and 60 mg theobromine per 500 mg capsule, so it can affect sleep if taken late, especially in people sensitive to caffeine. Theobromine is toxic to dogs and cats; keep away from pets. It may also interact with some medications. Chocamine is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Chocamine interact with any medications?

Possible interactions include: Stimulant medications: possible additive effects; use caution. Avoid taking late in the day if sensitive to stimulants. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Chocamine?

NutraSmarts rates the evidence for Chocamine as Preliminary (1 out of 5). It is backed by 1 study summary and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Ried K, Fakler P, Stocks NP. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. 2017;4(4):CD008893. doi: 10.1002/14651858.CD008893.pub3.PubMedUsed to support: Cochrane review of flavanol-rich cocoa products versus flavanol-free or low-flavanol controls (35 trials, 1,804 people) finding about a 1.76 mmHg short-term blood-pressure reduction. It did not test Chocamine or isolated theobromine, and did not measure energy, focus or mood.
  2. RFI Ingredients. Chocamine® by RFI Ingredients (supplier listing). NXT Ingredients. 2026;.SourceUsed to support: Supplier listing naming RFI Ingredients as the maker. It describes Chocamine as a patented, self-affirmed GRAS, water-soluble cocoa powder with chocolate taste and no sugar, fat or dairy, lists cocoa flavanols, theobromine, amino acids, anandamides and minerals, promotes it as stimulant-free energy and focus support, and gives 500 to 1,000 mg per serving. No standardization figures or studies are given. Not PubMed-indexed.
  3. Source Naturals. ChocoLift (Chocamine Plus cocoa extract) Supplement Facts label, NIH Dietary Supplement Label Database. NIH ODS DSLD. 2026;.SourceUsed to support: Product label listing 500 mg Chocamine Plus chocolate bean extract blend yielding 60 mg theobromine, 40 mg caffeine and 25 mg total polyphenols per capsule. A retail product, not a study. Not PubMed-indexed.