Cera-Q® (Silk Fibroin Peptides)

Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

Cera-Q is a peptide ingredient derived from silk fibroin, the protein of silkworm cocoons, studied for supporting memory. Also known as BF-7, the silk fibroin enzymatic hydrolysate has been examined in a small placebo-controlled human study that reported dose-dependent memory improvement, though independent evidence is still limited.

Studied Dose About 400 to 600 mg of fibroin hydrolysate per day, in divided doses.
Active Compound Silk fibroin-derived peptides (hydrolyzed silk protein fragments), also called BF-7.

Benefits

Memory support

In a small placebo-controlled, double-blind human study, a silk fibroin enzymatic hydrolysate produced dose-dependent improvements in memory test scores in healthy adults, the basis for the ingredient's memory positioning.

Learning and recall

Study participants showed gains in learning, the number of words remembered, and retrieval efficiency, suggesting support for everyday memory performance.

Antioxidant neuroprotection

Silk fibroin peptides show antioxidant activity that may help protect brain cells from oxidative stress, as observed in laboratory and animal research.

Mechanism of action

1

Antioxidant brain protection

Silk fibroin peptides reduce reactive oxygen species and oxidative stress in brain tissue in laboratory and animal models, a proposed basis for their memory effects.

2

Neuroprotective support

In animal studies, the silk peptide BF-7 reduced ischemic brain-cell damage while supporting learning and memory, consistent with a neuroprotective mechanism.

Clinical trials

1
Silk Fibroin Hydrolysate and Memory — Human RCT
PubMed

Placebo-controlled, double-blind study of a silk fibroin enzymatic hydrolysate at 280 to 600 mg per day for 3 weeks. (Kang et al. 2018, Nutrients)

Healthy adults (average age about 55).

The fibroin hydrolysate produced dose-dependent improvements in memory quotient and related memory measures versus placebo, with no adverse effects reported.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — no adverse effects were reported in the human study.
Silk-allergic individuals should avoid this ingredient.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Silk-allergic individuals should avoid this ingredient.
No major drug interactions are established.
Tell your doctor if pregnant, breastfeeding, or managing a condition.

Frequently asked questions about Cera-Q® (Silk Fibroin Peptides)

What is Cera-Q?

Cera-Q is a peptide ingredient derived from silk fibroin, the protein of silkworm cocoons, studied for supporting memory. Also known as BF-7, the silk fibroin enzymatic hydrolysate has been examined in a small placebo-controlled human study that reported dose-dependent memory improvement, though independent evidence is…

What is Cera-Q used for?

Cera-Q is researched primarily for Cognitive. In a small placebo-controlled, double-blind human study, a silk fibroin enzymatic hydrolysate produced dose-dependent improvements in memory test scores in healthy adults, the basis for the ingredient's memory positioning.

What is the recommended dosage of Cera-Q?

The clinically studied dose is About 400 to 600 mg of fibroin hydrolysate per day, in divided doses. Always follow the product label and check with a healthcare provider for personal advice.

Is Cera-Q safe, and does it have side effects?

For most healthy adults, Cera-Q is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — no adverse effects were reported in the human study. Silk-allergic individuals should avoid this ingredient. It may also interact with some medications. Cera-Q is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Cera-Q interact with any medications?

Possible interactions include: Silk-allergic individuals should avoid this ingredient. No major drug interactions are established. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Cera-Q?

NutraSmarts rates the evidence for Cera-Q as Limited (2 out of 5). It is backed by 1 clinical trial and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Kang YK, Lee BY, Bucci LR, Stohs SJ. Effect of a Fibroin Enzymatic Hydrolysate on Memory Improvement: A Placebo-Controlled, Double-Blind Study. Nutrients. 2018;10(2):233. doi: 10.3390/nu10020233..PubMedUsed to support: Human placebo-controlled study supporting memory benefit of silk fibroin hydrolysate.
  2. Noh Y, Ahn JH, Lee JW, et al. Brain Factor-7 improves learning and memory deficits and attenuates ischemic brain damage by reduction of ROS generation in stroke in vivo and in vitro. Lab Anim Res. 2020;36:24. doi: 10.1186/s42826-020-00057-x..PubMedUsed to support: Animal study supporting the neuroprotective and memory mechanism of silk fibroin peptide (BF-7).