Benefits
Cognition and memory
In one randomized, placebo-controlled trial of 28 healthy older adults over 2 months, working memory improved only in the group taking 750 mg of generic Centella asiatica extract a day. With roughly seven people per dose group this is a very small study, and it was not done on the Centellory brand.
Mood support
In the same 28-person trial, self-rated mood improved, again only in the 750 mg group. Mood was rated by participants themselves, and the result has not been repeated in a larger study.
Circulatory and skin support
Gotu kola is traditionally used for circulation and skin. This is traditional use only. No study cited on this page tested circulation or skin, and the Centellory research does not cover it.
Mechanism of action
Triterpene neuroprotection
Gotu kola's asiaticoside and madecassoside have been studied in the laboratory for effects on antioxidant defense and nerve-cell signaling. This is a proposed explanation, not something the human trial cited here measured.
Microcirculation support
The same triterpenes have been studied for effects on small blood vessels and collagen. This is a proposed mechanism only and was not tested in the trial cited here.
Clinical trials
Randomized, placebo-controlled trial of generic Centella asiatica extract at 250, 500 or 750 mg a day for 2 months. (Wattanathorn et al. 2008, Journal of Ethnopharmacology)
28 healthy elderly volunteers in total, split across three dose groups and placebo, so roughly seven people per group.
Only the 750 mg group improved: better working memory, a larger N100 brain-wave response and better self-rated mood. The 250 mg and 500 mg doses showed no benefit. The extract was generic Centella asiatica, not Centellory.