Benefits
Calm, focused cognition
In controlled human studies, lemon balm extract improved measures of alertness, memory, and calm mental performance, often within a few hours of a single dose.
Mood support
Lemon balm is studied for supporting a positive, settled mood alongside its cognitive effects.
Stress relief
The extract helps attenuate the mental and physical effects of acute stress, supporting a calm but alert state.
Mechanism of action
Cholinergic activity
Lemon balm compounds interact with acetylcholine (muscarinic and nicotinic) receptors involved in memory and attention, a basis for its cognitive effects.
GABA and rosmarinic acid action
Rosmarinic acid and related compounds support GABA signaling, contributing to the herb's calming, stress-easing effect.
Clinical trials
Controlled study of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). (Kennedy et al. 2002, Pharmacology, Biochemistry, and Behavior)
Healthy adults.
Lemon balm extract improved measures of calm and cognitive performance versus placebo.