Home Ingredients BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)
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BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

BioPQQ® is a fermentation-produced pyrroloquinoline quinone (PQQ) from Mitsubishi Gas Chemical, a vitamin-like redox compound studied for brain and mitochondrial support. PQQ is unusual in that it appears to promote the growth of new mitochondria, the cell's energy producers, and human studies have looked at its effects on memory, attention, and fatigue.

Studied Dose About 20 mg per day.
Active Compound Pyrroloquinoline quinone disodium salt (PQQ), a redox cofactor that supports mitochondrial function and acts as an antioxidant.

Benefits

Memory and cognition

PQQ supplementation has been studied for supporting memory and attention, particularly in older adults and people with age-related cognitive complaints.

Supported by Trial 1

Mitochondrial and energy support

PQQ is studied for promoting mitochondrial biogenesis and reducing fatigue, reflecting its role in cellular energy production.

Supported by Trial 1

Antioxidant protection

As a stable redox compound, PQQ cycles through many oxidation-reduction reactions, helping protect cells from oxidative stress.

Supported by Trial 1

Mechanism of action

1

Mitochondrial biogenesis

PQQ activates signaling pathways (such as PGC-1-alpha) that stimulate the creation of new mitochondria, supporting cellular energy capacity.

2

Redox cycling

PQQ can undergo thousands of oxidation-reduction cycles, giving it durable antioxidant activity that protects neurons and other cells.

Clinical trials

1
PQQ and Cognitive/Biological Function — Study
PubMed

Study of pyrroloquinoline quinone and a related imidazole compound on biological and cognitive function. (Yamada et al. 2020, Heliyon)

Adults.

PQQ supplementation was associated with supportive effects on cognitive and biological measures, consistent with its mitochondrial and antioxidant roles.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — side effects are uncommon at studied doses.
Mild headache or sleep changes are occasionally reported.
Take earlier in the day if it feels stimulating.

Important Drug interactions

No significant drug interactions are established.
Use caution combining with other stimulatory nootropics.
Tell your doctor if pregnant, breastfeeding, or managing a condition.

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Frequently asked questions about BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)

What is BioPQQ?

BioPQQ® is a fermentation-produced pyrroloquinoline quinone (PQQ) from Mitsubishi Gas Chemical, a vitamin-like redox compound studied for brain and mitochondrial support.

What is BioPQQ used for?

BioPQQ is researched primarily for Cognitive and Energy. PQQ supplementation has been studied for supporting memory and attention, particularly in older adults and people with age-related cognitive complaints.

What is the recommended dosage of BioPQQ?

The clinically studied dose is About 20 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is BioPQQ safe, and does it have side effects?

For most healthy adults, BioPQQ is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — side effects are uncommon at studied doses. Mild headache or sleep changes are occasionally reported. It may also interact with some medications. BioPQQ is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does BioPQQ interact with any medications?

Possible interactions include: No significant drug interactions are established. Use caution combining with other stimulatory nootropics. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for BioPQQ?

NutraSmarts rates the evidence for BioPQQ as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Yamada Y, Nishii K, Kuwata K, et al. Effects of pyrroloquinoline quinone and imidazole pyrroloquinoline on biological activities and neural functions. Heliyon. 2020;6(1):e03240..PubMedUsed to support: Study supporting PQQ cognitive and biological effects.