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BiAloe® (Aloe Vera Polysaccharides)

Aloe barbadensis
Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

BiAloe® is an aloe vera (Aloe barbadensis) ingredient concentrated for the long-chain acemannan polysaccharides thought to drive aloe's benefits. Aloe is traditionally used for digestive and skin support. Independent published clinical data for this specific ingredient are limited.

Studied Dose Commonly a few hundred milligrams per day, in the range of the 500 mg per day of a different aloe inner-leaf extract used in the irritable bowel studies, but well below the 1,200 to 3,600 mg per day of aloe gel used in the skin study.
Active Compound Aloe vera (Aloe barbadensis) inner-leaf extract concentrated for acemannan polysaccharides.

Benefits

Digestive support

Aloe vera inner leaf is traditionally used to soothe the digestive tract and support comfortable digestion. The human evidence is mixed: two randomized double-blind studies of a different aloe inner-leaf extract at 500 mg a day for four weeks both missed their main endpoint, and a benefit appeared only afterwards, when the two were pooled and analyzed by subgroup, in the 71 participants who had diarrhea-predominant irritable bowel syndrome, a diagnosed condition.

Skin support

Aloe polysaccharides are studied for skin support. The single oral study cited here gave 30 women over 45 an aloe gel drink for 90 days and measured smaller facial wrinkles, plus better elasticity in the lower-dose group, but it had no control group and no reported blinding, everyone was compared with their own baseline, and the rise in a collagen-building gene marker was not statistically significant. Skin hydration and wound healing were not measured in it.

Limited-evidence note

Aloe has a long traditional history, but dedicated published clinical trials for this specific concentrated ingredient are limited. The supplier publishes an acemannan specification of roughly 15 to 18 percent, yet neither study cited on this page reported the acemannan content of the aloe it used, so the acemannan positioning is not the thing that was tested. The one published human trial that did use this branded aloe gave it as one of twelve ingredients in a formula, with no control group, to a small group of people with Alzheimer's disease, so it cannot show what the ingredient does on its own or in healthy users.

Mechanism of action

1

Acemannan polysaccharides

Aloe's long-chain acemannan polysaccharides are studied in laboratory work for effects on the gut lining, immune cells, and skin tissue. That is a proposed mechanism rather than a benefit measured in people taking this ingredient.

2

Soothing and hydrating action

Aloe compounds provide soothing, hydrating, and antioxidant support to skin and the digestive tract.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well tolerated. Choose inner-leaf (decolorized) aloe, which is processed to remove aloin.
Whole-leaf aloe and aloe latex contain aloin, an anthraquinone stimulant laxative that can be harsh; avoid those forms. The FDA ruled in 2002 that aloe is not generally recognized as safe and effective as an over-the-counter stimulant laxative (21 CFR 310.545), a two-year US National Toxicology Program drinking-water study found that non-decolorized whole-leaf aloe vera extract caused large-intestine tumors in rats, and the International Agency for Research on Cancer classes whole-leaf aloe vera extract as possibly carcinogenic to humans. Those findings are about non-decolorized whole-leaf material and latex, not the decolorized inner-leaf gel used here.
Discontinue if digestive upset occurs.

Important Drug interactions

Diabetes medication: aloe may lower blood sugar, so monitor your levels.
Laxative-type aloe (leaf latex containing aloin) can lower potassium, which matters if you take digoxin, diuretics, or corticosteroids.
Tell your doctor if pregnant or breastfeeding.

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Frequently asked questions about BiAloe® (Aloe Vera Polysaccharides)

What is BiAloe?

BiAloe® is an aloe vera (Aloe barbadensis) ingredient concentrated for the long-chain acemannan polysaccharides thought to drive aloe's benefits. Aloe is traditionally used for digestive and skin support. Independent published clinical data for this specific ingredient are limited.

What is BiAloe used for?

BiAloe is researched primarily for Gut Health and Hair, Skin & Nails. Aloe vera inner leaf is traditionally used to soothe the digestive tract and support comfortable digestion. The human evidence is mixed: two randomized double-blind studies of a different aloe inner-leaf extract at 500 mg a day for four wee…

What is the recommended dosage of BiAloe?

The clinically studied dose is Commonly a few hundred milligrams per day, in the range of the 500 mg per day of a different aloe inner-leaf extract used in the irritable bowel studies, but well below the 1,200 to 3,600 mg per day of aloe gel used in the skin study. Always follow the product label and check with a healthcare provider for personal advice.

Is BiAloe safe, and does it have side effects?

For most healthy adults, BiAloe is well tolerated at studied doses. Reported effects can include: Generally well tolerated. Choose inner-leaf (decolorized) aloe, which is processed to remove aloin. Whole-leaf aloe and aloe latex contain aloin, an anthraquinone stimulant laxative that can be harsh; avoid those forms. It may also interact with some medications. BiAloe is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does BiAloe interact with any medications?

Possible interactions include: Diabetes medication: aloe may lower blood sugar, so monitor your levels. Laxative-type aloe (leaf latex containing aloin) can lower potassium, which matters if you take digoxin, diuretics, or corticosteroids. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for BiAloe?

NutraSmarts rates the evidence for BiAloe as Preliminary (1 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Ahluwalia B, Magnusson MK, Böhn L, Störsrud S, Larsson F, Öhman L, Simrén M Aloe barbadensis Mill. extract improves symptoms in IBS patients with diarrhoea: post hoc analysis of two randomized double-blind controlled studies Therapeutic Advances in Gastroenterology. 2021;14:17562848211048133. doi:10.1177/17562848211048133.PubMedUsed to support: Post-hoc analysis of two human RCTs (n=213 IBS patients) showing Aloe barbadensis extract reduced overall symptom severity in diarrhea-predominant IBS patients (58% of 38 people vs 30% of 33 on control treatment, p=0.02; the control tablets in both studies contained inulin rather than being inert, and both studies missed their own primary endpoints); this partly supports the digestive-support benefit of aloe vera polysaccharides relevant to BiAloe®. Evidence is for an Aloe barbadensis extract (AVH200®), not the BiAloe® brand specifically, and three of the authors are employees or part-time employees of the company that sells that extract.
  2. Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo Annals of Dermatology. 2009;21(1):6-11. doi:10.5021/ad.2009.21.1.6.PubMedUsed to support: Human clinical trial in 30 women over 45 showing oral aloe vera supplementation (1,200 mg/d and 3,600 mg/d for 90 days) improved measured facial wrinkles in both dose groups and elasticity only in the lower-dose group; the study had no control group and no reported blinding, each woman was compared with her own baseline, and the type I procollagen mRNA increase was not statistically significant, although procollagen staining did increase; this weakly supports the skin-support benefit attributed to aloe vera polysaccharides relevant to BiAloe®. Evidence is for an aloe vera gel drink, not the BiAloe® brand, and the doses used were several times a typical serving of this ingredient.
  3. Lewis JE, McDaniel HR, Agronin ME, et al. The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease. J Alzheimers Dis. 2013;33(2):393-406..PubMedUsed to support: This is the only published human trial that used this branded aloe: a 12-month open-label trial in people with Alzheimer's disease of an aloe polymannose multinutrient complex, a formula whose published composition names aloe leaf powder (BiAloe) as one of twelve ingredients. It reported cognitive scores and changes in cytokines and lymphocyte subsets, but there was no control group, no blinding, and no way to attribute any result to the aloe. It is cited here only so readers can see the design of the study behind this ingredient's reputation; it does not support any benefit claim for healthy users, and it is not an independent trial of the ingredient alone.