Appethyl® (Spinach Thylakoid Extract)

Appethyl® is a concentrated spinach (Spinacia oleracea) thylakoid extract, the green chlorophyll-containing membranes of spinach leaves. Taken before meals, thylakoids slow fat digestion and boost satiety hormones, and are studied for reducing hunger and cravings to support weight management.

Appethyl is researched primarily for Weight Management. In a randomized controlled trial, spinach thylakoid extract reduced hunger, increased satiety, and reduced cravings for palatable food in overweight women.

The clinically studied dose is Around 5 grams taken before a meal. Always follow the product label and check with a healthcare provider for personal advice.

For most healthy adults, Appethyl is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — digestive symptoms are most common. Mild bloating or changes in stool can occur. It may also interact with some medications. Appethyl is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Possible interactions include: Fat-soluble vitamin absorption may be modestly affected; maintain a balanced diet. Generally compatible with medications. If you take prescription medication, check with a pharmacist or doctor before using it.

NutraSmarts rates the evidence for Appethyl as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.