Home Ingredients Apigenius® (Apigenin)
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Apigenius® (Apigenin)

Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

Apigenius® supplies apigenin, a flavonoid found in chamomile, parsley, and celery that is best known as the calming compound in chamomile tea. Apigenin is used in relaxation and sleep formulas, though human clinical evidence for the isolated compound is still limited and mostly preliminary.

Studied Dose Commonly around 50 mg per day, often before bed.
Active Compound Apigenin, a flavone (flavonoid) found in chamomile and other plants.

Benefits

Relaxation and sleep

Apigenin is the flavonoid linked to chamomile's long traditional use for calm and sleep, and is used in modern relaxation and sleep formulas.

Calm and stress support

Apigenin is studied for gently supporting a relaxed state, though most evidence is preliminary or from laboratory research.

Antioxidant support

As a flavonoid, apigenin provides antioxidant activity.

Mechanism of action

1

GABA receptor interaction

Apigenin is thought to interact with benzodiazepine and GABA-A receptor sites in the brain, a proposed basis for its mild calming effect.

2

Antioxidant and anti-inflammatory action

Apigenin scavenges free radicals and modulates inflammatory signaling in laboratory studies.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Sedatives or sleep medication — possible additive calming effect; use caution.
Tell your doctor if pregnant or breastfeeding.
Use caution if combining with other sleep aids.

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Frequently asked questions about Apigenius® (Apigenin)

What is Apigenius?

Apigenius® supplies apigenin, a flavonoid found in chamomile, parsley, and celery that is best known as the calming compound in chamomile tea. Apigenin is used in relaxation and sleep formulas, though human clinical evidence for the isolated compound is still limited and mostly preliminary.

What is Apigenius used for?

Apigenius is researched primarily for Sleep Health and Stress & Anxiety. Apigenin is the flavonoid linked to chamomile's long traditional use for calm and sleep, and is used in modern relaxation and sleep formulas.

What is the recommended dosage of Apigenius?

The clinically studied dose is Commonly around 50 mg per day, often before bed. Always follow the product label and check with a healthcare provider for personal advice.

Is Apigenius safe, and does it have side effects?

For most healthy adults, Apigenius is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. It may also interact with some medications. Apigenius is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Apigenius interact with any medications?

Possible interactions include: Sedatives or sleep medication — possible additive calming effect; use caution. Tell your doctor if pregnant or breastfeeding. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Apigenius?

NutraSmarts rates the evidence for Apigenius as Preliminary (1 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla Biochemical Pharmacology. 2000;59(11):1387-94. doi:10.1016/s0006-2952(00)00264-1.PubMedUsed to support: In vitro and animal pharmacology study demonstrating apigenin binds the benzodiazepine site of the GABA-A receptor and exerts anxiolytic-like effects; provides the mechanistic basis for relaxation and calm/stress support benefit claims
  2. Kramer DJ, Johnson AA Apigenin: a natural molecule at the intersection of sleep and aging Frontiers in Nutrition. 2024;11:1359176. doi:10.3389/fnut.2024.1359176.PubMedUsed to support: Review article summarizing evidence that apigenin promotes sleep and may counter aging-related changes; supports the relaxation and sleep benefit claims while appropriately acknowledging that human clinical evidence for isolated apigenin remains limited
  3. Adib-Hajbaghery M, Mousavi SN The effects of chamomile extract on sleep quality among elderly people: a clinical trial Complementary Therapies in Medicine. 2017;35:109-114. doi:10.1016/j.ctim.2017.09.010.PubMedUsed to support: Human clinical trial showing chamomile extract (containing apigenin as key active) improves sleep quality in elderly individuals; supports sleep and relaxation benefits as component literature for apigenin's parent botanical source