AlgaeCal® (Plant-Sourced Calcium — Lithothamnion)

Lithothamnion superpositum
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

AlgaeCal® is a plant-sourced calcium derived from the marine red algae Lithothamnion, which absorbs calcium, magnesium, and dozens of trace minerals from seawater as it grows. Unlike rock-based calcium carbonate, it delivers calcium alongside its naturally occurring mineral cofactors, and the AlgaeCal Plus formula adds magnesium, boron, and vitamins D3 and K2. It is best known for a single 7-year open-label study in 172 women who were already taking the product, which reported a rise in bone mineral density. That study had no placebo group and no randomization, so the increase cannot be credited to the supplement itself.

Studied Dose Around 720 mg of elemental plant calcium per day as used in the manufacturer's product program, taken with the accompanying magnesium, trace minerals, vitamin D3, and vitamin K2. The one human study did not compare doses or test this against a placebo, so there is no trial-established dose here. Count calcium from food as well, and set your total intake with a doctor.
Active Compound Whole-algae calcium from Lithothamnion, naturally containing magnesium, boron, and 70-plus trace minerals; the AlgaeCal Plus formula adds vitamin D3 and vitamin K2 (MK-7).

Benefits

Bone mineral density

One 7-year study followed 172 women who had already been buying and taking this plant-calcium program for 1 to 7 years. Their bone mineral density rose about 1.04% per year, roughly 7.3% over the full 7 years, compared with an expected age-related loss of about 0.4% per year. Important caveats: nobody was randomized, there was no placebo group, and the comparison was against a database of expected decline rather than against real people taking nothing. People who keep buying and taking a bone supplement for seven years also tend to differ from everyone else in diet, exercise and health habits. So this is an encouraging long-term dataset, not proof that the supplement raised bone density.

Mineral cofactors for bone

The AlgaeCal Plus formula supplies magnesium, boron, vitamin D3, and vitamin K2 alongside the calcium. Vitamin D3 and K2 have their own bone research behind them, but the study cited on this page did not separate the calcium from these added nutrients, so there is no way to tell which part of the formula, if any, was responsible for what was measured.

Plant-based and food-form

As a whole-algae, food-form mineral, it offers a plant-based alternative to rock-derived calcium carbonate for people who prefer that source.

Mechanism of action

1

Bioavailable plant calcium

Calcium is delivered in a porous, food-bound algal matrix alongside trace minerals. The idea that this form is absorbed better than ordinary calcium carbonate is a proposed explanation, not something the study on this page tested; that study measured bone density in existing users and did not compare absorption against another calcium source.

2

Vitamin K2 and D3 cofactors

Vitamin D3 helps the body absorb calcium, and vitamin K2 activates two proteins, osteocalcin and matrix Gla protein, that are involved in how the body handles calcium. This is laboratory biology. The study cited on this page did not measure osteocalcin, artery calcium, or any heart outcome, so nothing here should be read as an effect on arteries.

Clinical trials

1
Plant Calcium and Bone Density: 7-Year Open-Label Study in Existing Users
PubMed

A 7-year open-label, uncontrolled longitudinal study of the AlgaeCal plant-calcium plus vitamin and mineral program (Kaats et al. 2016, Journal of the American College of Nutrition). Participants were not randomized and there was no placebo group. Everyone enrolled was already a customer who had been taking the product for 1 to 7 years. The 5,070-person comparison was a reference database of expected age-related bone loss, not people taking a comparison product.

172 women who completed DEXA bone scans and who had already been using the supplement for 1 to 7 years before the analysis. This is a self-selected group of long-term buyers, which is a serious source of bias.

Bone mineral density rose about 1.04% per year, roughly 7.3% over 7 years, against an expected age-related decline of about 0.4% per year. No safety concerns were reported over the seven years, which is genuinely useful long-term tolerability information. What the study cannot show is cause. With no randomization, no placebo group, and participants who had already chosen to take the product for years, the change could also reflect their diet, exercise, other supplements, or the way the expected-decline estimate was built. Treat this as one uncontrolled dataset, not as proof the supplement builds bone.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — mild digestive symptoms such as bloating or constipation can occur, as with any calcium.
Taking it with food and splitting the dose may make it easier on the stomach.
Excess total calcium from all sources should be avoided; stay within recommended daily limits. Osteoporosis, low bone density and fractures are medical conditions that need a doctor's diagnosis and management. This is a supplement, not a treatment for bone disease, and it should not replace care your clinician recommends.

Important Drug interactions

Thyroid medication (levothyroxine) — calcium can reduce absorption; separate by at least 4 hours.
Certain antibiotics (tetracyclines, fluoroquinolones) — calcium binds them; separate dosing.
Bisphosphonates — calcium interferes with absorption; take at a different time.

Frequently asked questions about AlgaeCal® (Plant-Sourced Calcium — Lithothamnion)

What is AlgaeCal?

AlgaeCal® is a plant-sourced calcium derived from the marine red algae Lithothamnion, which absorbs calcium, magnesium, and dozens of trace minerals from seawater as it grows.

What is AlgaeCal used for?

AlgaeCal is researched primarily for Bone Health. One 7-year study followed 172 women who had already been buying and taking this plant-calcium program for 1 to 7 years. Their bone mineral density rose about 1.04% per year, roughly 7.

What is the recommended dosage of AlgaeCal?

The clinically studied dose is Around 720 mg of elemental plant calcium per day as used in the manufacturer's product program, taken with the accompanying magnesium, trace minerals, vitamin D3, and vitamin K2. Always follow the product label and check with a healthcare provider for personal advice.

Is AlgaeCal safe, and does it have side effects?

For most healthy adults, AlgaeCal is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — mild digestive symptoms such as bloating or constipation can occur, as with any calcium. Taking it with food and splitting the dose may make it easier on the stomach. It may also interact with some medications. AlgaeCal is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does AlgaeCal interact with any medications?

Possible interactions include: Thyroid medication (levothyroxine) — calcium can reduce absorption; separate by at least 4 hours. Certain antibiotics (tetracyclines, fluoroquinolones) — calcium binds them; separate dosing. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for AlgaeCal?

NutraSmarts rates the evidence for AlgaeCal as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Kaats GR, Preuss HG, Stohs S, et al. A 7-Year Longitudinal Trial of the Safety and Efficacy of a Vitamin/Mineral Enhanced Plant-Sourced Calcium Supplement. J Am Coll Nutr. 2016;35(2):91-9..PubMedUsed to support: Open-label, uncontrolled 7-year observation of bone mineral density in 172 existing users of the branded product; reported an increase versus an expected-decline estimate, with no randomization or placebo group.