Deficiency Guide

Riboflavin deficiency

Symptoms, at-risk groups, and clinical context for riboflavin deficiency. Sourced from NIH Office of Dietary Supplements and StatPearls.

Riboflavin (vitamin B2) deficiency, also called ariboflavinosis, is extremely rare in the United States. Besides low intake, causes can include thyroid hormone insufficiency and some diseases. People who are low in riboflavin are usually low in other nutrients too, so some signs may reflect those other deficiencies.

Common symptoms

  • Cracks or sores at the corners of the mouth (angular stomatitis)
  • Swollen, cracked lips (cheilosis)
  • Redness and swelling of the mouth and throat; sore throat
  • Skin disorders
  • Itchy, red eyes
  • Hair loss
  • Anemia and cataracts when deficiency is severe and prolonged

At-risk groups

  • Vegetarian athletes, especially those who avoid milk, yogurt, cheese and eggs
  • Pregnant and breastfeeding women who rarely eat meat or dairy, and their infants
  • Vegans and people who consume little milk
  • People with riboflavin transporter deficiency, a rare inherited neurological disorder
When to see a doctorPersistent cracks at the corners of the mouth, a sore swollen mouth or throat, or itchy red eyes can have many causes, including low intake of several B vitamins. A doctor or dietitian can assess your diet and decide whether testing is needed.
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Related deficiencies

Nutrients with overlapping symptoms — useful when investigating an unclear clinical picture.